Dynamic kinetic resolution with enantioselective borohydride reduction catalyzed by optically active β-ketoiminato cobalt(II) complexes

Highly diastereo- and enantioselective preparation of optically active anti-aldol compounds

Yuhki Ohtsuka, Daichi Miyazaki, Taketo Ikeno, Tohru Yamada

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Optically active anti-2-alkyl-3-hydroxy esters were stereo-selectively obtained from the corresponding 2-alkyl-3-keto esters using enantioselective borohydride reduction along with dynamic kinetic resolution in the presence of optically active β-ketoiminato cobalt complex catalysts. The reduction system provided an alternative preparation for anti-aldol compounds with high diastereo- and enantioselectivities.

Original languageEnglish
Pages (from-to)24-25
Number of pages2
JournalChemistry Letters
Issue number1
Publication statusPublished - 2002 Jan 5

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Borohydrides
Cobalt
Esters
Kinetics
Enantioselectivity
Catalysts
3-hydroxybutanal

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

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abstract = "Optically active anti-2-alkyl-3-hydroxy esters were stereo-selectively obtained from the corresponding 2-alkyl-3-keto esters using enantioselective borohydride reduction along with dynamic kinetic resolution in the presence of optically active β-ketoiminato cobalt complex catalysts. The reduction system provided an alternative preparation for anti-aldol compounds with high diastereo- and enantioselectivities.",
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AU - Ohtsuka, Yuhki

AU - Miyazaki, Daichi

AU - Ikeno, Taketo

AU - Yamada, Tohru

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AB - Optically active anti-2-alkyl-3-hydroxy esters were stereo-selectively obtained from the corresponding 2-alkyl-3-keto esters using enantioselective borohydride reduction along with dynamic kinetic resolution in the presence of optically active β-ketoiminato cobalt complex catalysts. The reduction system provided an alternative preparation for anti-aldol compounds with high diastereo- and enantioselectivities.

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