Dynamic phantom with two stage-driven absorbers for mimicking hemoglobin changes in superficial and deep tissues

Tsukasa Funane, Hirokazu Atsumori, Masashi Kiguchi, Yukari Tanikaw, Eiji Okada

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

In near-infrared spectroscopy (NIRS) for monitoring brain activity and cerebral functional connectivity, the effect of superficial tissue on NIRS signals needs to be considered. Although some methods for determining the effect of scalp and brain have been proposed, direct validation of the methods has been difficult because the actual absorption changes cannot be known. In response to this problem, we developed a dynamic phantom that mimics hemoglobin changes in superficial and deep tissues, thus allowing us to experimentally validate the methods. Two absorber layers are independently driven with two one-axis automatic stages. We can use the phantom to design any type of waveform (e.g., brain activity or systemic fluctuation) of absorption change, which can then be reproducibly measured. To determine the effectiveness of the phantom, we used it for a multiple source-detector distance measurement. We also investigated the performance of a subtraction method with a short-distance regressor. The most accurate lower-layer change was obtained when a shortest-distance channel was used. Furthermore, when an independent component analysis was applied to the same data, the extracted components were in good agreement with the actual signals. These results demonstrate that the proposed phantom can be used for evaluating methods of discriminating the effects of superficial tissue.

Original languageEnglish
Article number047001-1
JournalJournal of Biomedical Optics
Volume17
Issue number4
DOIs
Publication statusPublished - 2012 Apr 1

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Keywords

  • Automatic stage
  • Biological tissue
  • Cerebral blood
  • Dynamic phantom
  • Independent component analysis
  • Multidistance measurement
  • Near-infrared spectroscopy
  • Scalp blood
  • Scanning system
  • Systemic fluctuation

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Biomedical Engineering

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