@article{ec8d77f9128744b98cd60612d711aac1,
title = "Dynamic subcellular localization of aquaporin-7 in white adipocytes",
abstract = "Aquaporin-7 (AQP7) is expressed in adipose tissue, permeated by water and glycerol, and is involved in lipid metabolism. AQP7-null mice develop obesity, insulin resistance, and adipocyte hypertrophy. Here, we show that AQP7 is expressed in adipocyte plasma membranes, and is re-localized to intracellular membranes in response to catecholamine in mouse white adipose tissue. We found that internalization of AQP7 was induced by PKA activation and comparative gene identification 58 (CGI-58). This relocation was confirmed by functional studies in 3T3-L1 adipocytes. Collectively, these results suggest that AQP7 makes several contributions to adipocyte metabolism, in both cortical and intracellular membranes.",
keywords = "Adipocyte, Aquaporin-7, Comparative gene identification 58, Lipolysis",
author = "Takayuki Miyauchi and Hiroyuki Yamamoto and Yoichiro Abe and Yoshida, {Go J.} and Aleksandra Rojek and Eisei Sohara and Shinichi Uchida and S{\o}ren Nielsen and Masato Yasui",
note = "Funding Information: We thank Drs. A. Sonoda, Y. Sohma, T. Morisaku, K. Ibata (Keio Univ.), H. H{\o}yer (Aarhus Univ.), A. Miyawaki (RIKEN), S. Takimoto, H. Kubo, Y. Arai, and T. Hashimoto (Olympus Co.) for their technical advices and supports; Dr. A. Miyawaki for Venus cDNA, Dr. R. Tsien (UCSD) for mCherry cDNA; Dr. D. Kojic (Keio Univ.) for critical reading of the manuscript. This work was supported by Japan Society for the Promotion of Science (Grant-in-Aid for Scientific Research KAKENHI 21657053 to T.M.), Japan Science and Technology Agency (Strategic International Research Cooperative Program to M.Y.), Nateglinide Memorial Toyoshima Research and Education Fund (to T.M., Y.A., and M.Y.), Keio Gakuji Academic Development Funds (to T.M. and M.Y.), and Keio University Special Grant-in-Aid for Innovative Collaborative Research Projects (to M.Y.). Publisher Copyright: {\textcopyright} 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.",
year = "2015",
month = feb,
day = "27",
doi = "10.1016/j.febslet.2015.01.025",
language = "English",
volume = "589",
pages = "608--614",
journal = "FEBS Letters",
issn = "0014-5793",
publisher = "Elsevier",
number = "5",
}
