TY - JOUR
T1 - Dynamically enhanced low-coherence interferometry
AU - Mitsui, Takahisa
AU - Aoki, Kenichiro
N1 - Funding Information:
The work was supported in part by the Grant–in–Aid for Scientific Research (Grant No. 15K05217) from the Japan Society for the Promotion of Science (JSPS) and a grant from Keio Gijuku Academic Development Funds.
Publisher Copyright:
© 2018 Author(s).
PY - 2018/9/1
Y1 - 2018/9/1
N2 - In the investigations of inhomogeneous media, availability of methods to study the interior of the material without affecting it is valuable. Optical coherence tomography provides such a functionality by providing depth resolved images of semi-transparent objects non-invasively. This is especially useful in medicine and is used not only in research but also in clinical practice. Optical coherence tomography characterizes each cross section by its reflectance. The basic physics principle underlying optical coherence tomography is low-coherence interferometry, which is combined with lateral scanning to produce cross sections. It is clearly desirable to obtain more detailed information regarding each cross section, if available. We have developed a system which measures the fluctuation spectra at all depths in low-coherence interferometry. By providing more information for each cross section, this can in principle be effective in tissue characterization and pathological diagnosis. The system uses the time dependence of the low-coherence interferometry data to obtain the fluctuation spectrum at each depth. Additionally, noise reduction is applied to obtain the spectra without unwanted noise, such as shot-noise, which can swamp the signal. The measurement system is applied to samples with no external stimuli, and depth resolved thermal fluctuation spectra of the samples are obtained. These spectra are compared with their corresponding theoretical expectations and are found to agree. The measurement system requires dualizing the detectors in the low-coherence interferometer but otherwise requires little additional equipment. The measurements were performed in ten to a hundred seconds.
AB - In the investigations of inhomogeneous media, availability of methods to study the interior of the material without affecting it is valuable. Optical coherence tomography provides such a functionality by providing depth resolved images of semi-transparent objects non-invasively. This is especially useful in medicine and is used not only in research but also in clinical practice. Optical coherence tomography characterizes each cross section by its reflectance. The basic physics principle underlying optical coherence tomography is low-coherence interferometry, which is combined with lateral scanning to produce cross sections. It is clearly desirable to obtain more detailed information regarding each cross section, if available. We have developed a system which measures the fluctuation spectra at all depths in low-coherence interferometry. By providing more information for each cross section, this can in principle be effective in tissue characterization and pathological diagnosis. The system uses the time dependence of the low-coherence interferometry data to obtain the fluctuation spectrum at each depth. Additionally, noise reduction is applied to obtain the spectra without unwanted noise, such as shot-noise, which can swamp the signal. The measurement system is applied to samples with no external stimuli, and depth resolved thermal fluctuation spectra of the samples are obtained. These spectra are compared with their corresponding theoretical expectations and are found to agree. The measurement system requires dualizing the detectors in the low-coherence interferometer but otherwise requires little additional equipment. The measurements were performed in ten to a hundred seconds.
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U2 - 10.1063/1.5025859
DO - 10.1063/1.5025859
M3 - Review article
C2 - 30278758
AN - SCOPUS:85053925003
SN - 0034-6748
VL - 89
JO - Review of Scientific Instruments
JF - Review of Scientific Instruments
IS - 9
M1 - 094302
ER -