Dynorphin B is present in sensory and parasympathetic nerves innervating pial arteries

Jan Erik Hardebo, Norihiro Suzuki, Christer Owman

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Abstract

Dynorphin B (dyn B) in trigeminal ganglion cells and in perivascular nerve fibers in pial arteries was demonstrated in rat, guinea-pig, and monkey by immunohistochemistry. The pathway from the trigeminal ganglion, which runs via the nasociliary nerve and ethmoidal foramen to the pial arteries, was shown in rat by retrograde tracer technique and nerve section. In the guinea-pig the peptide was demonstrated to coexist with substance P and calcitonin gene-related peptide in neurons of the trigeminal ganglion and pial nerve fibers, i.e., it was present in cerebrovascular sensory nerves with primarily nociceptive function. Another finding in guinea-pig was a coexistence of dyn B with vasoactive intestinal polypeptide in the pial nerve fibers and neurons of the sphenopalatine ganglion, indicating a presence also in parasympathetic nerves to the cerebral vessels. No vasomotor effect of dyn B could be detected in isolated segments of rat pial arteries, which rules out a direct postsynaptic effect on vascular tone. The peptide did not display a prejunctional modulatory action on the adrenergic nerves present in the vessels. The function of dyn B in the cerebrovascular nerves is discussed.

Original languageEnglish
Pages (from-to)171-176
Number of pages6
JournalJournal of the Autonomic Nervous System
Volume47
Issue number3
DOIs
Publication statusPublished - 1994 May

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Keywords

  • Cranial parasympathetic ganglia
  • Dynorphin
  • Immunohistochemistry
  • Parasympathetic nerve
  • Sensory nerve fiber
  • Trigeminal ganglion

ASJC Scopus subject areas

  • Neuroscience(all)
  • Physiology
  • Clinical Neurology

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