Dyslipidemia and cardiovascular disease

A series of epidemiologic studies in Japanese populations

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Although the causal relationships of high serum levels of total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) with coronary artery disease (CAD) are well established, there have been few community-based epidemiologic studies of these relations in Japan. Furthermore, even when analysis is restricted to ischemic stroke, the relationship between dyslipidemia and stroke is very weak. Accordingly, it is difficult to perform cohort studies of dyslipidemia and cardiovascular disease. A series of studies, such as the NIPPON DATA (National Integrated Project for Prospective Observation of Non-communicable Disease and Its Trends in the Aged) cohort study of a representative sample of Japanese, have greatly increased existing evidence. NIPPON DATA80 revealed a clear positive relationship between TC and CAD, and indicated that reverse causality between hypocholesterolemia and liver disease may increase all-cause mortality in hypocholesterolemic Japanese. NIPPON DATA90 showed that serum high-density lipoprotein cholesterol (HDL-C) was inversely associated with all-cause mortality, even when HDL-C was very high. NIPPON DATA80 revealed that low-normal levels of serum albumin and TC are associated with a decline in activity during old age, especially in women. The Suita study-a unique cohort study of urban residents-showed that LDL-C and non-HDL-C were equally accurate in predicting the incidence of myocardial infarction. Further research of this quality is needed to ascertain the public health burden of dyslipidemia in Japan.

Original languageEnglish
Pages (from-to)259-265
Number of pages7
JournalJournal of Epidemiology
Volume20
Issue number4
DOIs
Publication statusPublished - 2010
Externally publishedYes

Fingerprint

Dyslipidemias
Epidemiologic Studies
Cohort Studies
Cardiovascular Diseases
Cholesterol
LDL Cholesterol
HDL Cholesterol
Coronary Artery Disease
Japan
Stroke
Population
Mortality
Serum
Serum Albumin
Causality
Liver Diseases
Public Health
Myocardial Infarction
Observation
Incidence

Keywords

  • Cohort studies
  • Coronary artery disease
  • High density lipoprotein cholesterol
  • Low density lipoprotein cholesterol
  • Stroke
  • Total cholesterol

ASJC Scopus subject areas

  • Epidemiology
  • Medicine(all)

Cite this

Dyslipidemia and cardiovascular disease : A series of epidemiologic studies in Japanese populations. / Okamura, Tomonori.

In: Journal of Epidemiology, Vol. 20, No. 4, 2010, p. 259-265.

Research output: Contribution to journalArticle

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