Dyslipidemia in retinal metabolic disorders

Zhongjie Fu, Chuck T. Chen, Gael Cagnone, Emilie Heckel, Ye Sun, Bertan Cakir, Yohei Tomita, Shuo Huang, Qian Li, William Britton, Steve S. Cho, Timothy S. Kern, Ann Hellström, Jean Sébastien Joyal, Lois E.H. Smith

Research output: Contribution to journalReview articlepeer-review

36 Citations (Scopus)


The light-sensitive photoreceptors in the retina are extremely metabolically demanding and have the highest density of mitochondria of any cell in the body. Both physiological and pathological retinal vascular growth and regression are controlled by photoreceptor energy demands. It is critical to understand the energy demands of photoreceptors and fuel sources supplying them to understand neurovascular diseases. Retinas are very rich in lipids, which are continuously recycled as lipid-rich photoreceptor outer segments are shed and reformed and dietary intake of lipids modulates retinal lipid composition. Lipids (as well as glucose) are fuel substrates for photoreceptor mitochondria. Dyslipidemia contributes to the development and progression of retinal dysfunction in many eye diseases. Here, we review photoreceptor energy demands with a focus on lipid metabolism in retinal neurovascular disorders.

Original languageEnglish
Article numbere10473
JournalEMBO Molecular Medicine
Issue number10
Publication statusPublished - 2019 Oct 1
Externally publishedYes


  • FGF21
  • dyslipidemia
  • photoreceptor
  • retinal metabolism
  • β-oxidation

ASJC Scopus subject areas

  • Molecular Medicine


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