@article{3ee6902c5ae34ec3bfdd79fd243645aa,
title = "Dyslipidemia in retinal metabolic disorders",
abstract = "The light-sensitive photoreceptors in the retina are extremely metabolically demanding and have the highest density of mitochondria of any cell in the body. Both physiological and pathological retinal vascular growth and regression are controlled by photoreceptor energy demands. It is critical to understand the energy demands of photoreceptors and fuel sources supplying them to understand neurovascular diseases. Retinas are very rich in lipids, which are continuously recycled as lipid-rich photoreceptor outer segments are shed and reformed and dietary intake of lipids modulates retinal lipid composition. Lipids (as well as glucose) are fuel substrates for photoreceptor mitochondria. Dyslipidemia contributes to the development and progression of retinal dysfunction in many eye diseases. Here, we review photoreceptor energy demands with a focus on lipid metabolism in retinal neurovascular disorders.",
keywords = "FGF21, dyslipidemia, photoreceptor, retinal metabolism, β-oxidation",
author = "Zhongjie Fu and Chen, {Chuck T.} and Gael Cagnone and Emilie Heckel and Ye Sun and Bertan Cakir and Yohei Tomita and Shuo Huang and Qian Li and William Britton and Cho, {Steve S.} and Kern, {Timothy S.} and Ann Hellstr{\"o}m and Joyal, {Jean S{\'e}bastien} and Smith, {Lois E.H.}",
note = "Funding Information: LEHS is supported by NIH 1R24EY024868, EY017017-13S1, BCH IDDRC (1U54HD090255); AH is supported by The Swedish Research Council (DNR# #2016-01131), Government grants under the ALF agreement ALFGBG-717971 and the Wallenberg Foundations and long-term support by De Blindas V{\"a}nner; ZF is supported by Blind Children's Center, Manton Center for Orphan Disease Research, Boston Children's Hospital OFD/BTREC/CTREC Faculty Career Development Grant; BC is supported by Deutsche Forschungsgemeinschaft (CA 1940/1-1); QL is supported by Beijing Municipal Natural Science Foundation (#7192039); YS is supported by Boston Children's Hospital OFD/BTREC/CTREC Faculty Career Development Grant, NIH R01EY030140 and BrightFocus Foundation NIH/R01EY029238; YT is supported by Manpei Suzuki Diabetes Foundation; CTC is supported by Intramural Research Program at the National Institute on Alcohol Abuse and Alcoholism; TSK is supported by NIH grants EY022938 and R24 EY024864, and BX003604 from the Department of Veterans Affairs, TSK is the recipient of a Research Career Scientist award from the Department of Veterans Affairs. J-SJ is supported by Burroughs Wellcome Fund Career Award for Medical Scientists, NSERC RGPIN-2016-06743, CIHR 390615, FRQS, and a CIHR New Investigator Award. Publisher Copyright: {\textcopyright} 2019 The Authors. Published under the terms of the CC BY 4.0 license",
year = "2019",
month = oct,
day = "1",
doi = "10.15252/emmm.201910473",
language = "English",
volume = "11",
journal = "EMBO Molecular Medicine",
issn = "1757-4676",
publisher = "Wiley-Blackwell",
number = "10",
}