Dysregulation of the Synaptic Cytoskeleton in the PFC Drives Neural Circuit Pathology, Leading to Social Dysfunction

Il Hwan Kim, Namsoo Kim, Sunwhi Kim, Koji Toda, Christina M. Catavero, Jamie L. Courtland, Henry H. Yin, Scott H. Soderling

Research output: Contribution to journalArticlepeer-review

Abstract

Kim et al. exploit circuit-selective gene manipulation approaches in vivo to specifically knock out ArpC3 in the PFC-BLA circuit and find disrupted neuronal activities in the circuit, leading to abnormal social behavior. Optogenetic PFC-BLA circuit activation disrupts sociability of normal mice, while optogenetic circuit silencing rescues the abnormal sociability in the circuit knockout mice.

Original languageEnglish
Article number107965
JournalCell Reports
Volume32
Issue number4
DOIs
Publication statusPublished - 2020 Jul 28
Externally publishedYes

Keywords

  • Arp2/3
  • ArpC3
  • basolateral amygdala
  • circuit pathology
  • cytoskeleton
  • neural circuit
  • prefrontal cortex
  • schizophrenia
  • social behavior

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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