E-cell project: towards computer modeling of the whole cell

Research output: Contribution to journalArticle

Abstract

The E-CELL System (http://www.e-cell.org) is a genetic software package developed, to model not only metabolic pathways but also other higher-order cellular processes such as protein synthesis and signal transduction. Using the system, we have successfully constructed a virtual cell with 127 genes sufficient for 'self-support'. The gene set was selected from the genome of Mycoplasma genitalium, and the metabolisms include transcription, translation, membrane transport, the glycolysis pathway for energy production, and the phospholipid biosynthesis pathway or membrane structure.

Original languageEnglish
JournalAnnals of Biomedical Engineering
Volume28
Issue numberSUPPL. 1
Publication statusPublished - 2000

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Genes
Signal transduction
Membrane structures
Biosynthesis
Phospholipids
Transcription
Metabolism
Software packages
Proteins
Membranes
Glycolysis
Metabolic Networks and Pathways

ASJC Scopus subject areas

  • Biomedical Engineering

Cite this

E-cell project : towards computer modeling of the whole cell. / Tomita, Masaru.

In: Annals of Biomedical Engineering, Vol. 28, No. SUPPL. 1, 2000.

Research output: Contribution to journalArticle

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