Early and Late Leaflet Thrombosis After Transcatheter Aortic Valve Replacement

Ryo Yanagisawa, Makoto Tanaka, Fumiaki Yashima, Takahide Arai, Masahiro Jinzaki, Hideyuki Shimizu, Keiichi Fukuda, Yusuke Watanabe, Toru Naganuma, Akihiro Higashimori, Kazuki Mizutani, Motoharu Araki, Norio Tada, Futoshi Yamanaka, Toshiaki Otsuka, Masanori Yamamoto, Kentaro Hayashida

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

BACKGROUND: The occurrence and clinical impact of untreated subclinical leaflet thrombosis beyond 1 year after transcatheter aortic valve replacement still remain unclear. METHODS AND RESULTS: In a multicenter transcatheter aortic valve replacement registry, we analyzed data from 485 patients who underwent 4-dimensional multidetector computed tomography posttranscatheter aortic valve replacement performed to survey hypoattenuated leaflet thickening with reduced leaflet motion compatible with thrombus at a median of 3 days, 6 months, 1 year, 2 years, and 3 years. Incidence, predictors, and clinical outcomes of early (median 3 days) and late (>30 days) leaflet thrombosis were assessed. Additional anticoagulation was not administered because of subclinical findings at the time of computed tomography in all patients. Early leaflet thrombosis occurred in 45 (9.3%) of 485 patients. Mean pressure gradient at discharge was higher in patients with early leaflet thrombosis than in those without. Independent predictors of early leaflet thrombosis in balloon-expandable prostheses were low-flow, low-gradient aortic stenosis, severe prosthesis-patient mismatch, and 29-mm prostheses. No predictors could be identified for self-expanding prosthesis. Cumulative event rates of death, stroke, or rehospitalization for heart failure over 2 years were 10.7% and 16.9% in patients with and without early leaflet thrombosis, respectively ( P=0.63). Late leaflet thrombosis occurred late up to 3 years, and male sex and paravalvular leak less than mild were independent predictors. CONCLUSIONS: Untreated early leaflet thrombosis did not affect the cumulative event rates of death, stroke, and rehospitalization for heart failure. Late leaflet thrombosis was newly detected during 3-year follow-up. Visual Overview: A visual overview is available for this article.

Original languageEnglish
Pages (from-to)e007349
JournalCirculation. Cardiovascular interventions
Volume12
Issue number2
DOIs
Publication statusPublished - 2019 Feb 1

Fingerprint

Thrombosis
Prostheses and Implants
Heart Failure
Stroke
Transcatheter Aortic Valve Replacement
Multidetector Computed Tomography
Mortality
Aortic Valve Stenosis
Aortic Valve
Registries
Tomography
Pressure
Incidence

Keywords

  • aortic valve stenosis
  • heart failure
  • multidetector computed tomography
  • thrombosis
  • transcatheter aortic valve replacement

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Early and Late Leaflet Thrombosis After Transcatheter Aortic Valve Replacement. / Yanagisawa, Ryo; Tanaka, Makoto; Yashima, Fumiaki; Arai, Takahide; Jinzaki, Masahiro; Shimizu, Hideyuki; Fukuda, Keiichi; Watanabe, Yusuke; Naganuma, Toru; Higashimori, Akihiro; Mizutani, Kazuki; Araki, Motoharu; Tada, Norio; Yamanaka, Futoshi; Otsuka, Toshiaki; Yamamoto, Masanori; Hayashida, Kentaro.

In: Circulation. Cardiovascular interventions, Vol. 12, No. 2, 01.02.2019, p. e007349.

Research output: Contribution to journalArticle

Yanagisawa, R, Tanaka, M, Yashima, F, Arai, T, Jinzaki, M, Shimizu, H, Fukuda, K, Watanabe, Y, Naganuma, T, Higashimori, A, Mizutani, K, Araki, M, Tada, N, Yamanaka, F, Otsuka, T, Yamamoto, M & Hayashida, K 2019, 'Early and Late Leaflet Thrombosis After Transcatheter Aortic Valve Replacement', Circulation. Cardiovascular interventions, vol. 12, no. 2, pp. e007349. https://doi.org/10.1161/CIRCINTERVENTIONS.118.007349
Yanagisawa, Ryo ; Tanaka, Makoto ; Yashima, Fumiaki ; Arai, Takahide ; Jinzaki, Masahiro ; Shimizu, Hideyuki ; Fukuda, Keiichi ; Watanabe, Yusuke ; Naganuma, Toru ; Higashimori, Akihiro ; Mizutani, Kazuki ; Araki, Motoharu ; Tada, Norio ; Yamanaka, Futoshi ; Otsuka, Toshiaki ; Yamamoto, Masanori ; Hayashida, Kentaro. / Early and Late Leaflet Thrombosis After Transcatheter Aortic Valve Replacement. In: Circulation. Cardiovascular interventions. 2019 ; Vol. 12, No. 2. pp. e007349.
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AU - Jinzaki, Masahiro

AU - Shimizu, Hideyuki

AU - Fukuda, Keiichi

AU - Watanabe, Yusuke

AU - Naganuma, Toru

AU - Higashimori, Akihiro

AU - Mizutani, Kazuki

AU - Araki, Motoharu

AU - Tada, Norio

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N2 - BACKGROUND: The occurrence and clinical impact of untreated subclinical leaflet thrombosis beyond 1 year after transcatheter aortic valve replacement still remain unclear. METHODS AND RESULTS: In a multicenter transcatheter aortic valve replacement registry, we analyzed data from 485 patients who underwent 4-dimensional multidetector computed tomography posttranscatheter aortic valve replacement performed to survey hypoattenuated leaflet thickening with reduced leaflet motion compatible with thrombus at a median of 3 days, 6 months, 1 year, 2 years, and 3 years. Incidence, predictors, and clinical outcomes of early (median 3 days) and late (>30 days) leaflet thrombosis were assessed. Additional anticoagulation was not administered because of subclinical findings at the time of computed tomography in all patients. Early leaflet thrombosis occurred in 45 (9.3%) of 485 patients. Mean pressure gradient at discharge was higher in patients with early leaflet thrombosis than in those without. Independent predictors of early leaflet thrombosis in balloon-expandable prostheses were low-flow, low-gradient aortic stenosis, severe prosthesis-patient mismatch, and 29-mm prostheses. No predictors could be identified for self-expanding prosthesis. Cumulative event rates of death, stroke, or rehospitalization for heart failure over 2 years were 10.7% and 16.9% in patients with and without early leaflet thrombosis, respectively ( P=0.63). Late leaflet thrombosis occurred late up to 3 years, and male sex and paravalvular leak less than mild were independent predictors. CONCLUSIONS: Untreated early leaflet thrombosis did not affect the cumulative event rates of death, stroke, and rehospitalization for heart failure. Late leaflet thrombosis was newly detected during 3-year follow-up. Visual Overview: A visual overview is available for this article.

AB - BACKGROUND: The occurrence and clinical impact of untreated subclinical leaflet thrombosis beyond 1 year after transcatheter aortic valve replacement still remain unclear. METHODS AND RESULTS: In a multicenter transcatheter aortic valve replacement registry, we analyzed data from 485 patients who underwent 4-dimensional multidetector computed tomography posttranscatheter aortic valve replacement performed to survey hypoattenuated leaflet thickening with reduced leaflet motion compatible with thrombus at a median of 3 days, 6 months, 1 year, 2 years, and 3 years. Incidence, predictors, and clinical outcomes of early (median 3 days) and late (>30 days) leaflet thrombosis were assessed. Additional anticoagulation was not administered because of subclinical findings at the time of computed tomography in all patients. Early leaflet thrombosis occurred in 45 (9.3%) of 485 patients. Mean pressure gradient at discharge was higher in patients with early leaflet thrombosis than in those without. Independent predictors of early leaflet thrombosis in balloon-expandable prostheses were low-flow, low-gradient aortic stenosis, severe prosthesis-patient mismatch, and 29-mm prostheses. No predictors could be identified for self-expanding prosthesis. Cumulative event rates of death, stroke, or rehospitalization for heart failure over 2 years were 10.7% and 16.9% in patients with and without early leaflet thrombosis, respectively ( P=0.63). Late leaflet thrombosis occurred late up to 3 years, and male sex and paravalvular leak less than mild were independent predictors. CONCLUSIONS: Untreated early leaflet thrombosis did not affect the cumulative event rates of death, stroke, and rehospitalization for heart failure. Late leaflet thrombosis was newly detected during 3-year follow-up. Visual Overview: A visual overview is available for this article.

KW - aortic valve stenosis

KW - heart failure

KW - multidetector computed tomography

KW - thrombosis

KW - transcatheter aortic valve replacement

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