Early and late recurrence after intentional limited resection for cT1aN0M0, non-small cell lung cancer

From a multi-institutional, retrospective analysis in Japan

Yuki Matsumura, Motoki Yano, Junji Yoshida, Terumoto Koike, Kotaro Kameyama, Akira Shimamoto, Wataru Nishio, Kentaro Yoshimoto, Tomoki Utsumi, Takayuki Shiina, Atsushi Watanabe, Yasushi Yamato, Takehiro Watanabe, Yusuke Takahashi, Makoto Sonobe, Hiroaki Kuroda, Makoto Oda, Masayoshi Inoue, Masayuki Tanahashi, Hirofumi Adachi & 8 others Masao Saito, Masataro Hayashi, Hajime Otsuka, Teruaki Mizobuchi, Yasumitsu Moriya, Mamoru Takahashi, Shigeto Nishikawa, Hiroyuki Suzuki

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

OBJECTIVES In 2015, we reported the outcomes of patients undergoing intentional limited resection (ILR) for non-small-cell lung cancer (NSCLC) from a retrospective, multi-institutional large database in Japan. Here, we analyse the clinicopathological characteristics of the patients extracted from this database with late recurrence and compare them with those with early recurrence. METHODS Of 1538 patients in the database with cT1aN0M0 NSCLC, 92 (6%) had recurrence. In this study, early recurrence was defined as recurrence within 5 years and late recurrence as recurrence beyond 5 years after surgery. We compared the clinicopathological characteristics and post-recurrence survival (PRS) between patients with early and late recurrence. RESULTS Of the 92 patients with recurrence, 21 (23%) had late recurrence. Compared with the early recurrence group, there were significantly more adenocarcinomas and local recurrences in the late recurrence group (P = 0.04 for both). The 3- and 5-year PRS rates were 53 and 24%, respectively, and the median PRS period was 38 months. There were no significant differences in the PRS curves between patients with early and late recurrence (P = 0.12). Only 3 patients (0.2%) had recurrence more than 10 years after ILR. Of the 21 late-recurrence patients, 17 (81%) had tumours with a consolidation/tumour ratio (CTR) >0.25. CONCLUSIONS Late recurrence occurred in 21 (23%) of 92 patients with recurrence after ILR for cT1aN0M0 NSCLC. Late recurrence was more likely to involve adenocarcinoma and local recurrence. It is thus considered reasonable to follow patients with a CTR >0.25 for 10 years after ILR.

Original languageEnglish
Pages (from-to)444-449
Number of pages6
JournalInteractive Cardiovascular and Thoracic Surgery
Volume23
Issue number3
DOIs
Publication statusPublished - 2016 Sep 1
Externally publishedYes

Fingerprint

Non-Small Cell Lung Carcinoma
Japan
Recurrence
Databases
Survival
Adenocarcinoma
Neoplasms

Keywords

  • Intentional limited resection
  • Late recurrence
  • Non-small-cell lung cancer

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Early and late recurrence after intentional limited resection for cT1aN0M0, non-small cell lung cancer : From a multi-institutional, retrospective analysis in Japan. / Matsumura, Yuki; Yano, Motoki; Yoshida, Junji; Koike, Terumoto; Kameyama, Kotaro; Shimamoto, Akira; Nishio, Wataru; Yoshimoto, Kentaro; Utsumi, Tomoki; Shiina, Takayuki; Watanabe, Atsushi; Yamato, Yasushi; Watanabe, Takehiro; Takahashi, Yusuke; Sonobe, Makoto; Kuroda, Hiroaki; Oda, Makoto; Inoue, Masayoshi; Tanahashi, Masayuki; Adachi, Hirofumi; Saito, Masao; Hayashi, Masataro; Otsuka, Hajime; Mizobuchi, Teruaki; Moriya, Yasumitsu; Takahashi, Mamoru; Nishikawa, Shigeto; Suzuki, Hiroyuki.

In: Interactive Cardiovascular and Thoracic Surgery, Vol. 23, No. 3, 01.09.2016, p. 444-449.

Research output: Contribution to journalArticle

Matsumura, Y, Yano, M, Yoshida, J, Koike, T, Kameyama, K, Shimamoto, A, Nishio, W, Yoshimoto, K, Utsumi, T, Shiina, T, Watanabe, A, Yamato, Y, Watanabe, T, Takahashi, Y, Sonobe, M, Kuroda, H, Oda, M, Inoue, M, Tanahashi, M, Adachi, H, Saito, M, Hayashi, M, Otsuka, H, Mizobuchi, T, Moriya, Y, Takahashi, M, Nishikawa, S & Suzuki, H 2016, 'Early and late recurrence after intentional limited resection for cT1aN0M0, non-small cell lung cancer: From a multi-institutional, retrospective analysis in Japan', Interactive Cardiovascular and Thoracic Surgery, vol. 23, no. 3, pp. 444-449. https://doi.org/10.1093/icvts/ivw125
Matsumura, Yuki ; Yano, Motoki ; Yoshida, Junji ; Koike, Terumoto ; Kameyama, Kotaro ; Shimamoto, Akira ; Nishio, Wataru ; Yoshimoto, Kentaro ; Utsumi, Tomoki ; Shiina, Takayuki ; Watanabe, Atsushi ; Yamato, Yasushi ; Watanabe, Takehiro ; Takahashi, Yusuke ; Sonobe, Makoto ; Kuroda, Hiroaki ; Oda, Makoto ; Inoue, Masayoshi ; Tanahashi, Masayuki ; Adachi, Hirofumi ; Saito, Masao ; Hayashi, Masataro ; Otsuka, Hajime ; Mizobuchi, Teruaki ; Moriya, Yasumitsu ; Takahashi, Mamoru ; Nishikawa, Shigeto ; Suzuki, Hiroyuki. / Early and late recurrence after intentional limited resection for cT1aN0M0, non-small cell lung cancer : From a multi-institutional, retrospective analysis in Japan. In: Interactive Cardiovascular and Thoracic Surgery. 2016 ; Vol. 23, No. 3. pp. 444-449.
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abstract = "OBJECTIVES In 2015, we reported the outcomes of patients undergoing intentional limited resection (ILR) for non-small-cell lung cancer (NSCLC) from a retrospective, multi-institutional large database in Japan. Here, we analyse the clinicopathological characteristics of the patients extracted from this database with late recurrence and compare them with those with early recurrence. METHODS Of 1538 patients in the database with cT1aN0M0 NSCLC, 92 (6{\%}) had recurrence. In this study, early recurrence was defined as recurrence within 5 years and late recurrence as recurrence beyond 5 years after surgery. We compared the clinicopathological characteristics and post-recurrence survival (PRS) between patients with early and late recurrence. RESULTS Of the 92 patients with recurrence, 21 (23{\%}) had late recurrence. Compared with the early recurrence group, there were significantly more adenocarcinomas and local recurrences in the late recurrence group (P = 0.04 for both). The 3- and 5-year PRS rates were 53 and 24{\%}, respectively, and the median PRS period was 38 months. There were no significant differences in the PRS curves between patients with early and late recurrence (P = 0.12). Only 3 patients (0.2{\%}) had recurrence more than 10 years after ILR. Of the 21 late-recurrence patients, 17 (81{\%}) had tumours with a consolidation/tumour ratio (CTR) >0.25. CONCLUSIONS Late recurrence occurred in 21 (23{\%}) of 92 patients with recurrence after ILR for cT1aN0M0 NSCLC. Late recurrence was more likely to involve adenocarcinoma and local recurrence. It is thus considered reasonable to follow patients with a CTR >0.25 for 10 years after ILR.",
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T1 - Early and late recurrence after intentional limited resection for cT1aN0M0, non-small cell lung cancer

T2 - From a multi-institutional, retrospective analysis in Japan

AU - Matsumura, Yuki

AU - Yano, Motoki

AU - Yoshida, Junji

AU - Koike, Terumoto

AU - Kameyama, Kotaro

AU - Shimamoto, Akira

AU - Nishio, Wataru

AU - Yoshimoto, Kentaro

AU - Utsumi, Tomoki

AU - Shiina, Takayuki

AU - Watanabe, Atsushi

AU - Yamato, Yasushi

AU - Watanabe, Takehiro

AU - Takahashi, Yusuke

AU - Sonobe, Makoto

AU - Kuroda, Hiroaki

AU - Oda, Makoto

AU - Inoue, Masayoshi

AU - Tanahashi, Masayuki

AU - Adachi, Hirofumi

AU - Saito, Masao

AU - Hayashi, Masataro

AU - Otsuka, Hajime

AU - Mizobuchi, Teruaki

AU - Moriya, Yasumitsu

AU - Takahashi, Mamoru

AU - Nishikawa, Shigeto

AU - Suzuki, Hiroyuki

PY - 2016/9/1

Y1 - 2016/9/1

N2 - OBJECTIVES In 2015, we reported the outcomes of patients undergoing intentional limited resection (ILR) for non-small-cell lung cancer (NSCLC) from a retrospective, multi-institutional large database in Japan. Here, we analyse the clinicopathological characteristics of the patients extracted from this database with late recurrence and compare them with those with early recurrence. METHODS Of 1538 patients in the database with cT1aN0M0 NSCLC, 92 (6%) had recurrence. In this study, early recurrence was defined as recurrence within 5 years and late recurrence as recurrence beyond 5 years after surgery. We compared the clinicopathological characteristics and post-recurrence survival (PRS) between patients with early and late recurrence. RESULTS Of the 92 patients with recurrence, 21 (23%) had late recurrence. Compared with the early recurrence group, there were significantly more adenocarcinomas and local recurrences in the late recurrence group (P = 0.04 for both). The 3- and 5-year PRS rates were 53 and 24%, respectively, and the median PRS period was 38 months. There were no significant differences in the PRS curves between patients with early and late recurrence (P = 0.12). Only 3 patients (0.2%) had recurrence more than 10 years after ILR. Of the 21 late-recurrence patients, 17 (81%) had tumours with a consolidation/tumour ratio (CTR) >0.25. CONCLUSIONS Late recurrence occurred in 21 (23%) of 92 patients with recurrence after ILR for cT1aN0M0 NSCLC. Late recurrence was more likely to involve adenocarcinoma and local recurrence. It is thus considered reasonable to follow patients with a CTR >0.25 for 10 years after ILR.

AB - OBJECTIVES In 2015, we reported the outcomes of patients undergoing intentional limited resection (ILR) for non-small-cell lung cancer (NSCLC) from a retrospective, multi-institutional large database in Japan. Here, we analyse the clinicopathological characteristics of the patients extracted from this database with late recurrence and compare them with those with early recurrence. METHODS Of 1538 patients in the database with cT1aN0M0 NSCLC, 92 (6%) had recurrence. In this study, early recurrence was defined as recurrence within 5 years and late recurrence as recurrence beyond 5 years after surgery. We compared the clinicopathological characteristics and post-recurrence survival (PRS) between patients with early and late recurrence. RESULTS Of the 92 patients with recurrence, 21 (23%) had late recurrence. Compared with the early recurrence group, there were significantly more adenocarcinomas and local recurrences in the late recurrence group (P = 0.04 for both). The 3- and 5-year PRS rates were 53 and 24%, respectively, and the median PRS period was 38 months. There were no significant differences in the PRS curves between patients with early and late recurrence (P = 0.12). Only 3 patients (0.2%) had recurrence more than 10 years after ILR. Of the 21 late-recurrence patients, 17 (81%) had tumours with a consolidation/tumour ratio (CTR) >0.25. CONCLUSIONS Late recurrence occurred in 21 (23%) of 92 patients with recurrence after ILR for cT1aN0M0 NSCLC. Late recurrence was more likely to involve adenocarcinoma and local recurrence. It is thus considered reasonable to follow patients with a CTR >0.25 for 10 years after ILR.

KW - Intentional limited resection

KW - Late recurrence

KW - Non-small-cell lung cancer

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