Early CT signs in out-of-hospital cardiac arrest survivors: Temporal profile and prognostic significance

Joji Inamasu, Satoru Miyatake, Masaru Suzuki, Masashi Nakatsukasa, Hideto Tomioka, Masanori Honda, Kenichi Kase, Kenji Kobayashi

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

Aim: Although computed tomography (CT) signs of ischaemia, including loss of boundary (LOB) between grey matter and white matter and cortical sulcal effacement, in cardiac arrest (CA) survivors are known, their temporal profile and prognostic significance remains unclear; their clarification is necessary. Methods: Brain CT scans were obtained immediately after resuscitation in 75 non-traumatic CA survivors in a prospective fashion. They were divided into two groups according to the CA-return of spontaneous circulation (ROSC) interval: ≤20. min vs >20. min. The incidence of the CT signs and predictability of these signs for outcome, assessed 6 months after CA, was evaluated and compared. Results: The incidence of the positive LOB sign was 24% in the ≤20-min group and 83% in the >20-min group, and the difference was statistically significant (p<0.001). The interval of 20. min seemed to be the time window for the LOB development. The incidence of the positive sulcal effacement sign was 0% in the ≤20. min group and 34% in the >20-min group, and the difference was statistically significant (p=0.004). A positive LOB sign was predictive of unfavourable outcome with an 81% sensitivity and 92% specificity. A positive sulcal effacement sign was predictive of unfavourable outcome with a 32% sensitivity and 100% specificity. Conclusion: A time window may exist for ischaemic CT signs in CA survivors. The LOB sign may develop when the CA-ROSC interval exceeds 20. min, whereas the sulcal effacement sign may develop later. However, their temporal profile and outcome predictability should be verified by multicentre studies.

Original languageEnglish
Pages (from-to)534-538
Number of pages5
JournalResuscitation
Volume81
Issue number5
DOIs
Publication statusPublished - 2010 May
Externally publishedYes

Fingerprint

Out-of-Hospital Cardiac Arrest
Heart Arrest
Tomography
Sensitivity and Specificity
Incidence
Resuscitation
Multicenter Studies
Ischemia
Brain

Keywords

  • Early CT sign
  • Loss of boundary
  • Out-of-hospital cardiac arrest
  • Return of spontaneous circulation
  • Sulcal effacement

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Emergency
  • Emergency Medicine

Cite this

Inamasu, J., Miyatake, S., Suzuki, M., Nakatsukasa, M., Tomioka, H., Honda, M., ... Kobayashi, K. (2010). Early CT signs in out-of-hospital cardiac arrest survivors: Temporal profile and prognostic significance. Resuscitation, 81(5), 534-538. https://doi.org/10.1016/j.resuscitation.2010.01.012

Early CT signs in out-of-hospital cardiac arrest survivors : Temporal profile and prognostic significance. / Inamasu, Joji; Miyatake, Satoru; Suzuki, Masaru; Nakatsukasa, Masashi; Tomioka, Hideto; Honda, Masanori; Kase, Kenichi; Kobayashi, Kenji.

In: Resuscitation, Vol. 81, No. 5, 05.2010, p. 534-538.

Research output: Contribution to journalArticle

Inamasu, J, Miyatake, S, Suzuki, M, Nakatsukasa, M, Tomioka, H, Honda, M, Kase, K & Kobayashi, K 2010, 'Early CT signs in out-of-hospital cardiac arrest survivors: Temporal profile and prognostic significance', Resuscitation, vol. 81, no. 5, pp. 534-538. https://doi.org/10.1016/j.resuscitation.2010.01.012
Inamasu, Joji ; Miyatake, Satoru ; Suzuki, Masaru ; Nakatsukasa, Masashi ; Tomioka, Hideto ; Honda, Masanori ; Kase, Kenichi ; Kobayashi, Kenji. / Early CT signs in out-of-hospital cardiac arrest survivors : Temporal profile and prognostic significance. In: Resuscitation. 2010 ; Vol. 81, No. 5. pp. 534-538.
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AU - Tomioka, Hideto

AU - Honda, Masanori

AU - Kase, Kenichi

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KW - Return of spontaneous circulation

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