Early detection of gastric cancer after Helicobacter pylori eradication due to endoscopic surveillance

Kosuke Sakitani, Toshihiro Nishizawa, Masahide Arita, Shuntaro Yoshida, Yosuke Kataoka, Daisuke Ohki, Hiroharu Yamashita, Yoshihiro Isomura, Akira Toyoshima, Hidenobu Watanabe, Toshiro Iizuka, Yutaka Saito, Junko Fujisaki, Naohisa Yahagi, Kazuhiko Koike, Osamu Toyoshima

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: Helicobacter pylori eradication therapy is commonly performed to reduce the incidence of gastric cancer. However, gastric cancer is occasionally discovered even after successful eradication therapy. Therefore, we examined the prognosis of gastric cancer patients, diagnosed after successful H. pylori eradication therapy. Materials and Methods: All-cause death rates and gastric cancer-specific death rates in gastric cancer patients who received successful H. pylori eradication treatment was tracked and compared to rates in patients who did not receive successful eradication therapy. Results: In total, 160 gastric cancer patients were followed-up for up to 11.7 years (mean 3.5 years). Among them, 53 gastric cancer patients received successful H. pylori eradication therapy prior to gastric cancer diagnosis. During the follow-up period, 11 all-cause deaths occurred. In the successful eradication group, the proportion of patients with cancer stage I was higher. The proportions of patients who received curative endoscopic therapy and endoscopic examination in the 2 years prior to gastric cancer diagnosis were also higher in the successful eradication group. Kaplan–Meier analysis of all-cause death and gastric cancer-specific death revealed a lower death rate in patients in the successful eradication group (P =.0139, and P =.0396, respectively, log-rank test). The multivariate analysis showed that endoscopy within 2 years before cancer diagnosis is associated with stage I cancer. Conclusions: Possible early discovery of gastric cancer after H. pylori eradication due to regular endoscopic surveillance may contribute to better prognosis of patients with gastric cancer.

Original languageEnglish
Article numbere12503
JournalHelicobacter
Volume23
Issue number4
DOIs
Publication statusPublished - 2018 Aug 1

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Early Detection of Cancer
Helicobacter pylori
Stomach Neoplasms
Pylorus
Cause of Death
Therapeutics
Mortality
Neoplasms
Endoscopy
Multivariate Analysis

Keywords

  • endoscopic surveillance
  • gastric cancer
  • H. pylori eradication
  • mortality rate

ASJC Scopus subject areas

  • Gastroenterology
  • Infectious Diseases

Cite this

Sakitani, K., Nishizawa, T., Arita, M., Yoshida, S., Kataoka, Y., Ohki, D., ... Toyoshima, O. (2018). Early detection of gastric cancer after Helicobacter pylori eradication due to endoscopic surveillance. Helicobacter, 23(4), [e12503]. https://doi.org/10.1111/hel.12503

Early detection of gastric cancer after Helicobacter pylori eradication due to endoscopic surveillance. / Sakitani, Kosuke; Nishizawa, Toshihiro; Arita, Masahide; Yoshida, Shuntaro; Kataoka, Yosuke; Ohki, Daisuke; Yamashita, Hiroharu; Isomura, Yoshihiro; Toyoshima, Akira; Watanabe, Hidenobu; Iizuka, Toshiro; Saito, Yutaka; Fujisaki, Junko; Yahagi, Naohisa; Koike, Kazuhiko; Toyoshima, Osamu.

In: Helicobacter, Vol. 23, No. 4, e12503, 01.08.2018.

Research output: Contribution to journalArticle

Sakitani, K, Nishizawa, T, Arita, M, Yoshida, S, Kataoka, Y, Ohki, D, Yamashita, H, Isomura, Y, Toyoshima, A, Watanabe, H, Iizuka, T, Saito, Y, Fujisaki, J, Yahagi, N, Koike, K & Toyoshima, O 2018, 'Early detection of gastric cancer after Helicobacter pylori eradication due to endoscopic surveillance', Helicobacter, vol. 23, no. 4, e12503. https://doi.org/10.1111/hel.12503
Sakitani K, Nishizawa T, Arita M, Yoshida S, Kataoka Y, Ohki D et al. Early detection of gastric cancer after Helicobacter pylori eradication due to endoscopic surveillance. Helicobacter. 2018 Aug 1;23(4). e12503. https://doi.org/10.1111/hel.12503
Sakitani, Kosuke ; Nishizawa, Toshihiro ; Arita, Masahide ; Yoshida, Shuntaro ; Kataoka, Yosuke ; Ohki, Daisuke ; Yamashita, Hiroharu ; Isomura, Yoshihiro ; Toyoshima, Akira ; Watanabe, Hidenobu ; Iizuka, Toshiro ; Saito, Yutaka ; Fujisaki, Junko ; Yahagi, Naohisa ; Koike, Kazuhiko ; Toyoshima, Osamu. / Early detection of gastric cancer after Helicobacter pylori eradication due to endoscopic surveillance. In: Helicobacter. 2018 ; Vol. 23, No. 4.
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abstract = "Background: Helicobacter pylori eradication therapy is commonly performed to reduce the incidence of gastric cancer. However, gastric cancer is occasionally discovered even after successful eradication therapy. Therefore, we examined the prognosis of gastric cancer patients, diagnosed after successful H. pylori eradication therapy. Materials and Methods: All-cause death rates and gastric cancer-specific death rates in gastric cancer patients who received successful H. pylori eradication treatment was tracked and compared to rates in patients who did not receive successful eradication therapy. Results: In total, 160 gastric cancer patients were followed-up for up to 11.7 years (mean 3.5 years). Among them, 53 gastric cancer patients received successful H. pylori eradication therapy prior to gastric cancer diagnosis. During the follow-up period, 11 all-cause deaths occurred. In the successful eradication group, the proportion of patients with cancer stage I was higher. The proportions of patients who received curative endoscopic therapy and endoscopic examination in the 2 years prior to gastric cancer diagnosis were also higher in the successful eradication group. Kaplan–Meier analysis of all-cause death and gastric cancer-specific death revealed a lower death rate in patients in the successful eradication group (P =.0139, and P =.0396, respectively, log-rank test). The multivariate analysis showed that endoscopy within 2 years before cancer diagnosis is associated with stage I cancer. Conclusions: Possible early discovery of gastric cancer after H. pylori eradication due to regular endoscopic surveillance may contribute to better prognosis of patients with gastric cancer.",
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AU - Nishizawa, Toshihiro

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AU - Kataoka, Yosuke

AU - Ohki, Daisuke

AU - Yamashita, Hiroharu

AU - Isomura, Yoshihiro

AU - Toyoshima, Akira

AU - Watanabe, Hidenobu

AU - Iizuka, Toshiro

AU - Saito, Yutaka

AU - Fujisaki, Junko

AU - Yahagi, Naohisa

AU - Koike, Kazuhiko

AU - Toyoshima, Osamu

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N2 - Background: Helicobacter pylori eradication therapy is commonly performed to reduce the incidence of gastric cancer. However, gastric cancer is occasionally discovered even after successful eradication therapy. Therefore, we examined the prognosis of gastric cancer patients, diagnosed after successful H. pylori eradication therapy. Materials and Methods: All-cause death rates and gastric cancer-specific death rates in gastric cancer patients who received successful H. pylori eradication treatment was tracked and compared to rates in patients who did not receive successful eradication therapy. Results: In total, 160 gastric cancer patients were followed-up for up to 11.7 years (mean 3.5 years). Among them, 53 gastric cancer patients received successful H. pylori eradication therapy prior to gastric cancer diagnosis. During the follow-up period, 11 all-cause deaths occurred. In the successful eradication group, the proportion of patients with cancer stage I was higher. The proportions of patients who received curative endoscopic therapy and endoscopic examination in the 2 years prior to gastric cancer diagnosis were also higher in the successful eradication group. Kaplan–Meier analysis of all-cause death and gastric cancer-specific death revealed a lower death rate in patients in the successful eradication group (P =.0139, and P =.0396, respectively, log-rank test). The multivariate analysis showed that endoscopy within 2 years before cancer diagnosis is associated with stage I cancer. Conclusions: Possible early discovery of gastric cancer after H. pylori eradication due to regular endoscopic surveillance may contribute to better prognosis of patients with gastric cancer.

AB - Background: Helicobacter pylori eradication therapy is commonly performed to reduce the incidence of gastric cancer. However, gastric cancer is occasionally discovered even after successful eradication therapy. Therefore, we examined the prognosis of gastric cancer patients, diagnosed after successful H. pylori eradication therapy. Materials and Methods: All-cause death rates and gastric cancer-specific death rates in gastric cancer patients who received successful H. pylori eradication treatment was tracked and compared to rates in patients who did not receive successful eradication therapy. Results: In total, 160 gastric cancer patients were followed-up for up to 11.7 years (mean 3.5 years). Among them, 53 gastric cancer patients received successful H. pylori eradication therapy prior to gastric cancer diagnosis. During the follow-up period, 11 all-cause deaths occurred. In the successful eradication group, the proportion of patients with cancer stage I was higher. The proportions of patients who received curative endoscopic therapy and endoscopic examination in the 2 years prior to gastric cancer diagnosis were also higher in the successful eradication group. Kaplan–Meier analysis of all-cause death and gastric cancer-specific death revealed a lower death rate in patients in the successful eradication group (P =.0139, and P =.0396, respectively, log-rank test). The multivariate analysis showed that endoscopy within 2 years before cancer diagnosis is associated with stage I cancer. Conclusions: Possible early discovery of gastric cancer after H. pylori eradication due to regular endoscopic surveillance may contribute to better prognosis of patients with gastric cancer.

KW - endoscopic surveillance

KW - gastric cancer

KW - H. pylori eradication

KW - mortality rate

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