Early detection of superficial squamous cell carcinoma in the head and neck region and esophagus by narrow band imaging: A multicenter randomized controlled trial

Manabu Muto, Keiko Minashi, Tomonori Yano, Yutaka Saito, Ichiro Oda, Satoru Nonaka, Tai Omori, Hitoshi Sugiura, Kenichi Goda, Mitsuru Kaise, Haruhiro Inoue, Hideki Ishikawa, Atsushi Ochiai, Tadakazu Shimoda, Hidenobu Watanabe, Hisao Tajiri, Daizo Saito

Research output: Contribution to journalArticle

318 Citations (Scopus)

Abstract

Purpose: Most of the esophageal squamous cell carcinomas (ESCCs) and cancers of the head and neck (H&N) region are diagnosed at later stages. To achieve better survival, early detection is necessary. We compared the real-time diagnostic yield of superficial cancer in these regions between conventional white light imaging (WLI) and narrow band imaging (NBI) in high-risk patients. Patients and Methods: In a multicenter, prospective, randomized controlled trial, 320 patients with ESCC were randomly assigned to primary WLI followed by NBI (n = 162) or primary NBI followed by WLI (n = 158) in a back-to-back fashion. The primary aim was to compare the real-time detection rates of superficial cancer in the H&N region and the esophagus between WLI and NBI. The secondary aim was to evaluate the diagnostic accuracy of these techniques. Results: NBI detected superficial cancer more frequently than did WLI in both the H&N region and the esophagus (100% v 8%, P < .001; 97% v 55%, P < .001, respectively). The sensitivity of NBI for diagnosis of superficial cancer was 100% and 97.2% in the H&N region and the esophagus, respectively. The accuracy of NBI for diagnosis of superficial cancer was 86.7% and 88.9% in these regions, respectively. The sensitivity and accuracy were significantly higher using NBI than WLI in both regions (P < .001 and P = .02 for the H&N region; P < .001 for both measures for the esophagus, respectively). Conclusion: NBI could be the standard examination for the early detection of superficial cancer in the H&N region and the esophagus.

Original languageEnglish
Pages (from-to)1566-1572
Number of pages7
JournalJournal of Clinical Oncology
Volume28
Issue number9
DOIs
Publication statusPublished - 2010 Mar 20

Fingerprint

Narrow Band Imaging
Esophagus
Randomized Controlled Trials
Light
Neoplasms
Carcinoma, squamous cell of head and neck
Squamous Cell Neoplasms
Esophageal Neoplasms
Head and Neck Neoplasms
Early Detection of Cancer

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Medicine(all)

Cite this

Early detection of superficial squamous cell carcinoma in the head and neck region and esophagus by narrow band imaging : A multicenter randomized controlled trial. / Muto, Manabu; Minashi, Keiko; Yano, Tomonori; Saito, Yutaka; Oda, Ichiro; Nonaka, Satoru; Omori, Tai; Sugiura, Hitoshi; Goda, Kenichi; Kaise, Mitsuru; Inoue, Haruhiro; Ishikawa, Hideki; Ochiai, Atsushi; Shimoda, Tadakazu; Watanabe, Hidenobu; Tajiri, Hisao; Saito, Daizo.

In: Journal of Clinical Oncology, Vol. 28, No. 9, 20.03.2010, p. 1566-1572.

Research output: Contribution to journalArticle

Muto, M, Minashi, K, Yano, T, Saito, Y, Oda, I, Nonaka, S, Omori, T, Sugiura, H, Goda, K, Kaise, M, Inoue, H, Ishikawa, H, Ochiai, A, Shimoda, T, Watanabe, H, Tajiri, H & Saito, D 2010, 'Early detection of superficial squamous cell carcinoma in the head and neck region and esophagus by narrow band imaging: A multicenter randomized controlled trial', Journal of Clinical Oncology, vol. 28, no. 9, pp. 1566-1572. https://doi.org/10.1200/JCO.2009.25.4680
Muto, Manabu ; Minashi, Keiko ; Yano, Tomonori ; Saito, Yutaka ; Oda, Ichiro ; Nonaka, Satoru ; Omori, Tai ; Sugiura, Hitoshi ; Goda, Kenichi ; Kaise, Mitsuru ; Inoue, Haruhiro ; Ishikawa, Hideki ; Ochiai, Atsushi ; Shimoda, Tadakazu ; Watanabe, Hidenobu ; Tajiri, Hisao ; Saito, Daizo. / Early detection of superficial squamous cell carcinoma in the head and neck region and esophagus by narrow band imaging : A multicenter randomized controlled trial. In: Journal of Clinical Oncology. 2010 ; Vol. 28, No. 9. pp. 1566-1572.
@article{819d9083e5244a0a9f788e3ddb58c207,
title = "Early detection of superficial squamous cell carcinoma in the head and neck region and esophagus by narrow band imaging: A multicenter randomized controlled trial",
abstract = "Purpose: Most of the esophageal squamous cell carcinomas (ESCCs) and cancers of the head and neck (H&N) region are diagnosed at later stages. To achieve better survival, early detection is necessary. We compared the real-time diagnostic yield of superficial cancer in these regions between conventional white light imaging (WLI) and narrow band imaging (NBI) in high-risk patients. Patients and Methods: In a multicenter, prospective, randomized controlled trial, 320 patients with ESCC were randomly assigned to primary WLI followed by NBI (n = 162) or primary NBI followed by WLI (n = 158) in a back-to-back fashion. The primary aim was to compare the real-time detection rates of superficial cancer in the H&N region and the esophagus between WLI and NBI. The secondary aim was to evaluate the diagnostic accuracy of these techniques. Results: NBI detected superficial cancer more frequently than did WLI in both the H&N region and the esophagus (100{\%} v 8{\%}, P < .001; 97{\%} v 55{\%}, P < .001, respectively). The sensitivity of NBI for diagnosis of superficial cancer was 100{\%} and 97.2{\%} in the H&N region and the esophagus, respectively. The accuracy of NBI for diagnosis of superficial cancer was 86.7{\%} and 88.9{\%} in these regions, respectively. The sensitivity and accuracy were significantly higher using NBI than WLI in both regions (P < .001 and P = .02 for the H&N region; P < .001 for both measures for the esophagus, respectively). Conclusion: NBI could be the standard examination for the early detection of superficial cancer in the H&N region and the esophagus.",
author = "Manabu Muto and Keiko Minashi and Tomonori Yano and Yutaka Saito and Ichiro Oda and Satoru Nonaka and Tai Omori and Hitoshi Sugiura and Kenichi Goda and Mitsuru Kaise and Haruhiro Inoue and Hideki Ishikawa and Atsushi Ochiai and Tadakazu Shimoda and Hidenobu Watanabe and Hisao Tajiri and Daizo Saito",
year = "2010",
month = "3",
day = "20",
doi = "10.1200/JCO.2009.25.4680",
language = "English",
volume = "28",
pages = "1566--1572",
journal = "Journal of Clinical Oncology",
issn = "0732-183X",
publisher = "American Society of Clinical Oncology",
number = "9",

}

TY - JOUR

T1 - Early detection of superficial squamous cell carcinoma in the head and neck region and esophagus by narrow band imaging

T2 - A multicenter randomized controlled trial

AU - Muto, Manabu

AU - Minashi, Keiko

AU - Yano, Tomonori

AU - Saito, Yutaka

AU - Oda, Ichiro

AU - Nonaka, Satoru

AU - Omori, Tai

AU - Sugiura, Hitoshi

AU - Goda, Kenichi

AU - Kaise, Mitsuru

AU - Inoue, Haruhiro

AU - Ishikawa, Hideki

AU - Ochiai, Atsushi

AU - Shimoda, Tadakazu

AU - Watanabe, Hidenobu

AU - Tajiri, Hisao

AU - Saito, Daizo

PY - 2010/3/20

Y1 - 2010/3/20

N2 - Purpose: Most of the esophageal squamous cell carcinomas (ESCCs) and cancers of the head and neck (H&N) region are diagnosed at later stages. To achieve better survival, early detection is necessary. We compared the real-time diagnostic yield of superficial cancer in these regions between conventional white light imaging (WLI) and narrow band imaging (NBI) in high-risk patients. Patients and Methods: In a multicenter, prospective, randomized controlled trial, 320 patients with ESCC were randomly assigned to primary WLI followed by NBI (n = 162) or primary NBI followed by WLI (n = 158) in a back-to-back fashion. The primary aim was to compare the real-time detection rates of superficial cancer in the H&N region and the esophagus between WLI and NBI. The secondary aim was to evaluate the diagnostic accuracy of these techniques. Results: NBI detected superficial cancer more frequently than did WLI in both the H&N region and the esophagus (100% v 8%, P < .001; 97% v 55%, P < .001, respectively). The sensitivity of NBI for diagnosis of superficial cancer was 100% and 97.2% in the H&N region and the esophagus, respectively. The accuracy of NBI for diagnosis of superficial cancer was 86.7% and 88.9% in these regions, respectively. The sensitivity and accuracy were significantly higher using NBI than WLI in both regions (P < .001 and P = .02 for the H&N region; P < .001 for both measures for the esophagus, respectively). Conclusion: NBI could be the standard examination for the early detection of superficial cancer in the H&N region and the esophagus.

AB - Purpose: Most of the esophageal squamous cell carcinomas (ESCCs) and cancers of the head and neck (H&N) region are diagnosed at later stages. To achieve better survival, early detection is necessary. We compared the real-time diagnostic yield of superficial cancer in these regions between conventional white light imaging (WLI) and narrow band imaging (NBI) in high-risk patients. Patients and Methods: In a multicenter, prospective, randomized controlled trial, 320 patients with ESCC were randomly assigned to primary WLI followed by NBI (n = 162) or primary NBI followed by WLI (n = 158) in a back-to-back fashion. The primary aim was to compare the real-time detection rates of superficial cancer in the H&N region and the esophagus between WLI and NBI. The secondary aim was to evaluate the diagnostic accuracy of these techniques. Results: NBI detected superficial cancer more frequently than did WLI in both the H&N region and the esophagus (100% v 8%, P < .001; 97% v 55%, P < .001, respectively). The sensitivity of NBI for diagnosis of superficial cancer was 100% and 97.2% in the H&N region and the esophagus, respectively. The accuracy of NBI for diagnosis of superficial cancer was 86.7% and 88.9% in these regions, respectively. The sensitivity and accuracy were significantly higher using NBI than WLI in both regions (P < .001 and P = .02 for the H&N region; P < .001 for both measures for the esophagus, respectively). Conclusion: NBI could be the standard examination for the early detection of superficial cancer in the H&N region and the esophagus.

UR - http://www.scopus.com/inward/record.url?scp=77951923657&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77951923657&partnerID=8YFLogxK

U2 - 10.1200/JCO.2009.25.4680

DO - 10.1200/JCO.2009.25.4680

M3 - Article

C2 - 20177025

AN - SCOPUS:77951923657

VL - 28

SP - 1566

EP - 1572

JO - Journal of Clinical Oncology

JF - Journal of Clinical Oncology

SN - 0732-183X

IS - 9

ER -