Early life nutrient restriction impairs blood-brain metabolic profile and neurobehavior predisposing to Alzheimer's disease with aging

Masatoshi Tomi, Yuanzi Zhao, Shanthie Thamotharan, Bo Chul Shin, Sherin U. Devaskar

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Prenatal nutrient restriction (NR) culminating in intra-uterine growth restriction (IUGR) with postnatal catch up growth leads to diabesity. In contrast, postnatal NR with growth restriction (PNGR) superimposed on IUGR (IPGR) protects young and aging adults from this phenotype. We hypothesized that PNGR/IPGR will compromise the blood-brain metabolic profile impairing neurobehavior and predisposing to Alzheimer's disease (AD). NR (50%) in late gestation followed by cross-fostering of rat pups to either ad lib fed (CON) or NR (50%) lactating mothers generated CON, IUGR, PNGR and IPGR male (M) and female (F) offspring that were examined through the life span. In PNGR/IPGR plasma/CSF glucose and lactate decreased while ketones increased in (M) and (F) (PN21, PN50). In addition increased brain glucose transporters, Glut1 & Glut3, greater brain derived neurotrophic factor (BDNF), reduced Glut4, with unchanged serotonin transporter concentrations were noted in (F) (PN50-60). While (F) displayed more hyperactivity, both (F) and (M) exhibited anxiety although socially and cognitively unimpaired (PN25-28&50). Aging (15-17 m) (F) not (M), expressed low plasma insulin, reduced brain IRS-2, pAkt, and pGSK-3βSer9, unchanged pPDK1, pTau or lipoprotein receptor related protein 1 (LRP1), higher glial fibrillary acidic protein (GFAP) and spinophilin but a 10-fold increased amyloid-β42. We conclude that therapeutically superimposing PNGR on IUGR (IPGR) should be carefully weighed in light of unintended consequences related to perturbed neurobehavior and potential predilection for AD.

Original languageEnglish
Pages (from-to)61-75
Number of pages15
JournalBrain Research
Volume1495
DOIs
Publication statusPublished - 2013 Feb 7
Externally publishedYes

Fingerprint

Metabolome
Alzheimer Disease
Food
Brain
Growth
Lipoprotein Receptors
Serotonin Plasma Membrane Transport Proteins
Foster Home Care
Facilitative Glucose Transport Proteins
Glial Fibrillary Acidic Protein
Brain-Derived Neurotrophic Factor
Ketones
Amyloid
Young Adult
Lactic Acid
Anxiety
Mothers
Insulin
Phenotype
Glucose

Keywords

  • Alzheimer's disease
  • Amyloid beta
  • Anxiety
  • Insulin
  • Nutrient restriction

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology
  • Developmental Biology
  • Molecular Biology

Cite this

Early life nutrient restriction impairs blood-brain metabolic profile and neurobehavior predisposing to Alzheimer's disease with aging. / Tomi, Masatoshi; Zhao, Yuanzi; Thamotharan, Shanthie; Shin, Bo Chul; Devaskar, Sherin U.

In: Brain Research, Vol. 1495, 07.02.2013, p. 61-75.

Research output: Contribution to journalArticle

Tomi, Masatoshi ; Zhao, Yuanzi ; Thamotharan, Shanthie ; Shin, Bo Chul ; Devaskar, Sherin U. / Early life nutrient restriction impairs blood-brain metabolic profile and neurobehavior predisposing to Alzheimer's disease with aging. In: Brain Research. 2013 ; Vol. 1495. pp. 61-75.
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