Early serial Q-switched ruby laser therapy for medium-sized to giant congenital melanocytic naevi

Kazuo Kishi, Keisuke Okabe, R. Ninomiya, E. Konno, Noriko Aramaki, K. Katsube, Nobuaki Imanishi, H. Nakajima, T. Nakajima

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Background Medium-sized to giant congenital melanocytic naevi (CMN) are difficult to treat, especially if the lesions appear on the face or extremities where treated areas are visible and cosmesis is important. Objectives In infants, nests of pigmented naevus reside more superficially and the skin is more transparent than in adults, so we treated medium-sized to giant CMN with early serial Q-switched ruby laser therapy from infancy. Patients and methods We treated nine patients with medium-sized to giant CMN on the face or upper limbs from 1 month of age with early serial Q-switched ruby laser therapy. The laser power was initially 5 J cm) 2 and increased in 0 5 J cm) 2 steps to a maximum of 10 J cm) 2. There were three treatment sites on the forehead, one on the temple, one on the cheek and four on the upper arm. Results It took 8-15 treatments for the CMN to become a colour similar to the surrounding skin. The mean number of treatments was 9 6. The colour was reduced to 0-20% of the colour of the baseline lesion in all nine patients. Partial slight repigmentation occurred in eight of these patients. These naevi were treated with an additional one or two Q-switched ruby laser irradiations and successfully lightened for at least 1 year. In the remaining patient, pigmentation returned to a level similar to the original lesion within 1 month of the last treatment. Therefore, the lesion was excised for cosmetic reasons. After the treatment series, the skin texture was fine and no patients had hypertrophic scarring. Conclusions Although treatment of one patient with the Q-switched ruby laser therapy failed, the remaining patients responded well and had good to excellent skin texture without hypertrophic scarring. Early serial Q-switched ruby laser treatment, starting from infancy, is a promising treatment method for this condition.

Original languageEnglish
Pages (from-to)345-352
Number of pages8
JournalBritish Journal of Dermatology
Volume161
Issue number2
DOIs
Publication statusPublished - 2009

Fingerprint

Pigmented Nevus
Solid-State Lasers
Laser Therapy
Lasers
Skin
Color
Therapeutics
Cicatrix
Forehead
Cheek
Nevus
Pigmentation
Upper Extremity
Cosmetics
Arm
Extremities

Keywords

  • Early
  • Giant congenital melanocytic naevi
  • Infant
  • Q-switched ruby laser
  • Serial

ASJC Scopus subject areas

  • Dermatology
  • Medicine(all)

Cite this

Early serial Q-switched ruby laser therapy for medium-sized to giant congenital melanocytic naevi. / Kishi, Kazuo; Okabe, Keisuke; Ninomiya, R.; Konno, E.; Aramaki, Noriko; Katsube, K.; Imanishi, Nobuaki; Nakajima, H.; Nakajima, T.

In: British Journal of Dermatology, Vol. 161, No. 2, 2009, p. 345-352.

Research output: Contribution to journalArticle

@article{1a69441541fb4a69858326cf15903cd6,
title = "Early serial Q-switched ruby laser therapy for medium-sized to giant congenital melanocytic naevi",
abstract = "Background Medium-sized to giant congenital melanocytic naevi (CMN) are difficult to treat, especially if the lesions appear on the face or extremities where treated areas are visible and cosmesis is important. Objectives In infants, nests of pigmented naevus reside more superficially and the skin is more transparent than in adults, so we treated medium-sized to giant CMN with early serial Q-switched ruby laser therapy from infancy. Patients and methods We treated nine patients with medium-sized to giant CMN on the face or upper limbs from 1 month of age with early serial Q-switched ruby laser therapy. The laser power was initially 5 J cm) 2 and increased in 0 5 J cm) 2 steps to a maximum of 10 J cm) 2. There were three treatment sites on the forehead, one on the temple, one on the cheek and four on the upper arm. Results It took 8-15 treatments for the CMN to become a colour similar to the surrounding skin. The mean number of treatments was 9 6. The colour was reduced to 0-20{\%} of the colour of the baseline lesion in all nine patients. Partial slight repigmentation occurred in eight of these patients. These naevi were treated with an additional one or two Q-switched ruby laser irradiations and successfully lightened for at least 1 year. In the remaining patient, pigmentation returned to a level similar to the original lesion within 1 month of the last treatment. Therefore, the lesion was excised for cosmetic reasons. After the treatment series, the skin texture was fine and no patients had hypertrophic scarring. Conclusions Although treatment of one patient with the Q-switched ruby laser therapy failed, the remaining patients responded well and had good to excellent skin texture without hypertrophic scarring. Early serial Q-switched ruby laser treatment, starting from infancy, is a promising treatment method for this condition.",
keywords = "Early, Giant congenital melanocytic naevi, Infant, Q-switched ruby laser, Serial",
author = "Kazuo Kishi and Keisuke Okabe and R. Ninomiya and E. Konno and Noriko Aramaki and K. Katsube and Nobuaki Imanishi and H. Nakajima and T. Nakajima",
year = "2009",
doi = "10.1111/j.1365-2133.2009.09153.x",
language = "English",
volume = "161",
pages = "345--352",
journal = "British Journal of Dermatology",
issn = "0007-0963",
publisher = "Wiley-Blackwell",
number = "2",

}

TY - JOUR

T1 - Early serial Q-switched ruby laser therapy for medium-sized to giant congenital melanocytic naevi

AU - Kishi, Kazuo

AU - Okabe, Keisuke

AU - Ninomiya, R.

AU - Konno, E.

AU - Aramaki, Noriko

AU - Katsube, K.

AU - Imanishi, Nobuaki

AU - Nakajima, H.

AU - Nakajima, T.

PY - 2009

Y1 - 2009

N2 - Background Medium-sized to giant congenital melanocytic naevi (CMN) are difficult to treat, especially if the lesions appear on the face or extremities where treated areas are visible and cosmesis is important. Objectives In infants, nests of pigmented naevus reside more superficially and the skin is more transparent than in adults, so we treated medium-sized to giant CMN with early serial Q-switched ruby laser therapy from infancy. Patients and methods We treated nine patients with medium-sized to giant CMN on the face or upper limbs from 1 month of age with early serial Q-switched ruby laser therapy. The laser power was initially 5 J cm) 2 and increased in 0 5 J cm) 2 steps to a maximum of 10 J cm) 2. There were three treatment sites on the forehead, one on the temple, one on the cheek and four on the upper arm. Results It took 8-15 treatments for the CMN to become a colour similar to the surrounding skin. The mean number of treatments was 9 6. The colour was reduced to 0-20% of the colour of the baseline lesion in all nine patients. Partial slight repigmentation occurred in eight of these patients. These naevi were treated with an additional one or two Q-switched ruby laser irradiations and successfully lightened for at least 1 year. In the remaining patient, pigmentation returned to a level similar to the original lesion within 1 month of the last treatment. Therefore, the lesion was excised for cosmetic reasons. After the treatment series, the skin texture was fine and no patients had hypertrophic scarring. Conclusions Although treatment of one patient with the Q-switched ruby laser therapy failed, the remaining patients responded well and had good to excellent skin texture without hypertrophic scarring. Early serial Q-switched ruby laser treatment, starting from infancy, is a promising treatment method for this condition.

AB - Background Medium-sized to giant congenital melanocytic naevi (CMN) are difficult to treat, especially if the lesions appear on the face or extremities where treated areas are visible and cosmesis is important. Objectives In infants, nests of pigmented naevus reside more superficially and the skin is more transparent than in adults, so we treated medium-sized to giant CMN with early serial Q-switched ruby laser therapy from infancy. Patients and methods We treated nine patients with medium-sized to giant CMN on the face or upper limbs from 1 month of age with early serial Q-switched ruby laser therapy. The laser power was initially 5 J cm) 2 and increased in 0 5 J cm) 2 steps to a maximum of 10 J cm) 2. There were three treatment sites on the forehead, one on the temple, one on the cheek and four on the upper arm. Results It took 8-15 treatments for the CMN to become a colour similar to the surrounding skin. The mean number of treatments was 9 6. The colour was reduced to 0-20% of the colour of the baseline lesion in all nine patients. Partial slight repigmentation occurred in eight of these patients. These naevi were treated with an additional one or two Q-switched ruby laser irradiations and successfully lightened for at least 1 year. In the remaining patient, pigmentation returned to a level similar to the original lesion within 1 month of the last treatment. Therefore, the lesion was excised for cosmetic reasons. After the treatment series, the skin texture was fine and no patients had hypertrophic scarring. Conclusions Although treatment of one patient with the Q-switched ruby laser therapy failed, the remaining patients responded well and had good to excellent skin texture without hypertrophic scarring. Early serial Q-switched ruby laser treatment, starting from infancy, is a promising treatment method for this condition.

KW - Early

KW - Giant congenital melanocytic naevi

KW - Infant

KW - Q-switched ruby laser

KW - Serial

UR - http://www.scopus.com/inward/record.url?scp=73349108457&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=73349108457&partnerID=8YFLogxK

U2 - 10.1111/j.1365-2133.2009.09153.x

DO - 10.1111/j.1365-2133.2009.09153.x

M3 - Article

C2 - 19438478

AN - SCOPUS:73349108457

VL - 161

SP - 345

EP - 352

JO - British Journal of Dermatology

JF - British Journal of Dermatology

SN - 0007-0963

IS - 2

ER -