Early tumor cavitation with regorafenib in metastatic colorectal cancer: A case report

Kenta Kawasaki, Yasuo Hamamoto, Masayuki Adachi, Takanori Kanai, Hiromasa Takaishi

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


Tumoral cavity formation is a characteristic phenomenon reported in anti-angiogenic therapy in lung lesions. A 57-year-old male with multiple pulmonary metastases from colorectal cancer treated with an oral tyrosine kinase inhibitor, regorafenib, exhibited a characteristic cavity formation after the first two cycles. The decrease in the size of tumors was calculated as 38%, and there were associated decreases in the serum concentrations of the tumor markers carcinoembryonic antigen and CA19-9. After eight cycles of treatment, the cavity gradually disappeared through filling-in. This unique morphological response is not only reported in lung cancer but also in liver metastasis in colorectal cancer. However, the association between morphological changes including cavity formation and clinical benefit remains controversial. Pulmonary hemorrhage and pneumothorax are well-known consequences of cavitation, as reported with the other anti-angiogenic inhibitors. Early tumor cavitation in lung metastasis may demonstrate the predictive potential of regorafenib in colorectal cancer, although it is necessary to be mindful of toxicity.

Original languageEnglish
Pages (from-to)231-233
Number of pages3
JournalOncology Letters
Issue number1
Publication statusPublished - 2016 Jan


  • Cavity formation
  • Colorectal cancer
  • Lung metastasis
  • Regorafenib

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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