Early use of beta-blockers is associated with attenuation of serum C-reactive protein elevation and favorable short-term prognosis after acute myocardial infarction

Toshihisa Anzai, Tsutomu Yoshikawa, Toshiyuki Takahashi, Yuichiro Maekawa, Teruo Okabe, Yasushi Asakura, Toru Satoh, Hideo Mitamura, Satoshi Ogawa

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Background: We have reported that a marked elevation in serum C-reactive protein (CRP) level is a predictor for infarct expansion and cardiac rupture after AMI. Although β-blockers prevent cardiac rupture after AMI, their effect on serum CRP elevation has not been determined. Methods: We studied a total of 154 patients with first Q-wave AMI. Patients complicated by pump failure were excluded from this study. Eighty-two patients received β-blocker treatment within 24 h of the onset of AMI, while 72 patients received no β-blocker treatment. Peak serum creatine kinase (CK) and CRP levels were determined by serial measurements. Results: There was no difference between the groups according to age, sex, coronary risk factors, pre-infarction angina, infarct site, prior use of cardiovascular drugs, use of revascularization therapy, and prevalence of multivessel disease. β-Blocker treatment was associated with a lower peak CRP level (6.9 ± 6.1 vs. 10.8 ± 9.3 mg/dl, p =0.002), a shorter duration from the onset to the peak CRP level (2 ± 1 vs. 3 ± 2 days, p < 0.0001), a lower incidence of cardiac rupture (p =0.03) and lower in-hospital cardiac mortality (p =0.02), despite similar peak CK levels. Conclusion: The early use of β-blockers is associated with decreased serum CRP level and a favorable clinical outcome after first Q-wave AMI, suggesting some beneficial effects of β-blockers on infarct healing after AMI.

Original languageEnglish
Pages (from-to)47-53
Number of pages7
JournalCardiology
Volume99
Issue number1
DOIs
Publication statusPublished - 2003

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C-Reactive Protein
Blood Proteins
Myocardial Infarction
Heart Rupture
Creatine Kinase
Cardiovascular Agents
Therapeutics
Hospital Mortality
Infarction
Incidence
Serum

Keywords

  • β-Blocker
  • C-reactive protein
  • Cardiac rupture
  • Inflammation
  • Myocardial infarction

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Early use of beta-blockers is associated with attenuation of serum C-reactive protein elevation and favorable short-term prognosis after acute myocardial infarction. / Anzai, Toshihisa; Yoshikawa, Tsutomu; Takahashi, Toshiyuki; Maekawa, Yuichiro; Okabe, Teruo; Asakura, Yasushi; Satoh, Toru; Mitamura, Hideo; Ogawa, Satoshi.

In: Cardiology, Vol. 99, No. 1, 2003, p. 47-53.

Research output: Contribution to journalArticle

Anzai, T, Yoshikawa, T, Takahashi, T, Maekawa, Y, Okabe, T, Asakura, Y, Satoh, T, Mitamura, H & Ogawa, S 2003, 'Early use of beta-blockers is associated with attenuation of serum C-reactive protein elevation and favorable short-term prognosis after acute myocardial infarction', Cardiology, vol. 99, no. 1, pp. 47-53. https://doi.org/10.1159/000068449
Anzai, Toshihisa ; Yoshikawa, Tsutomu ; Takahashi, Toshiyuki ; Maekawa, Yuichiro ; Okabe, Teruo ; Asakura, Yasushi ; Satoh, Toru ; Mitamura, Hideo ; Ogawa, Satoshi. / Early use of beta-blockers is associated with attenuation of serum C-reactive protein elevation and favorable short-term prognosis after acute myocardial infarction. In: Cardiology. 2003 ; Vol. 99, No. 1. pp. 47-53.
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AU - Anzai, Toshihisa

AU - Yoshikawa, Tsutomu

AU - Takahashi, Toshiyuki

AU - Maekawa, Yuichiro

AU - Okabe, Teruo

AU - Asakura, Yasushi

AU - Satoh, Toru

AU - Mitamura, Hideo

AU - Ogawa, Satoshi

PY - 2003

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N2 - Background: We have reported that a marked elevation in serum C-reactive protein (CRP) level is a predictor for infarct expansion and cardiac rupture after AMI. Although β-blockers prevent cardiac rupture after AMI, their effect on serum CRP elevation has not been determined. Methods: We studied a total of 154 patients with first Q-wave AMI. Patients complicated by pump failure were excluded from this study. Eighty-two patients received β-blocker treatment within 24 h of the onset of AMI, while 72 patients received no β-blocker treatment. Peak serum creatine kinase (CK) and CRP levels were determined by serial measurements. Results: There was no difference between the groups according to age, sex, coronary risk factors, pre-infarction angina, infarct site, prior use of cardiovascular drugs, use of revascularization therapy, and prevalence of multivessel disease. β-Blocker treatment was associated with a lower peak CRP level (6.9 ± 6.1 vs. 10.8 ± 9.3 mg/dl, p =0.002), a shorter duration from the onset to the peak CRP level (2 ± 1 vs. 3 ± 2 days, p < 0.0001), a lower incidence of cardiac rupture (p =0.03) and lower in-hospital cardiac mortality (p =0.02), despite similar peak CK levels. Conclusion: The early use of β-blockers is associated with decreased serum CRP level and a favorable clinical outcome after first Q-wave AMI, suggesting some beneficial effects of β-blockers on infarct healing after AMI.

AB - Background: We have reported that a marked elevation in serum C-reactive protein (CRP) level is a predictor for infarct expansion and cardiac rupture after AMI. Although β-blockers prevent cardiac rupture after AMI, their effect on serum CRP elevation has not been determined. Methods: We studied a total of 154 patients with first Q-wave AMI. Patients complicated by pump failure were excluded from this study. Eighty-two patients received β-blocker treatment within 24 h of the onset of AMI, while 72 patients received no β-blocker treatment. Peak serum creatine kinase (CK) and CRP levels were determined by serial measurements. Results: There was no difference between the groups according to age, sex, coronary risk factors, pre-infarction angina, infarct site, prior use of cardiovascular drugs, use of revascularization therapy, and prevalence of multivessel disease. β-Blocker treatment was associated with a lower peak CRP level (6.9 ± 6.1 vs. 10.8 ± 9.3 mg/dl, p =0.002), a shorter duration from the onset to the peak CRP level (2 ± 1 vs. 3 ± 2 days, p < 0.0001), a lower incidence of cardiac rupture (p =0.03) and lower in-hospital cardiac mortality (p =0.02), despite similar peak CK levels. Conclusion: The early use of β-blockers is associated with decreased serum CRP level and a favorable clinical outcome after first Q-wave AMI, suggesting some beneficial effects of β-blockers on infarct healing after AMI.

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KW - Myocardial infarction

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