Early vs. late reverse ventricular remodeling in patients with cardiomyopathy

Aya Banno, Shun Kohsaka, Taku Inohara, Kimi Koide, Yasuyuki Shiraishi, Takashi Kohno, Motoaki Sano, Tsutomu Yoshikawa, Keiichi Fukuda

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: Predictors of left ventricular reverse remodeling (LVRR) and differences in the time taken to achieve LVRR remain unclear. Methods: We consecutively registered 129 patients with severe cardiomyopathy admitted with heart failure (HF). Patients were followed for a median of 778.0 days (IQ: 457.0, 1078.0). LVRR was defined as a decrease in indexed left ventricular systolic dimension of at least 15% additional to a 25% improvement in left ventricular ejection fraction at outpatient check-up compared with discharge. LVRR accomplishment within 400 days was defined as early-LVRR opposing the remaining late-LVRR patients. Primary endpoint was a composite of all-cause mortality and HF re-hospitalization. Results: LVRR was observed in 51 patients (39.5%). Baseline predictors for LVRR were age younger than 60 years (OR, 3.27; 95% CI 1.04-10.37, . p =0.043), no history of previous HF hospitalization (OR, 0.32; 95% CI 0.12-0.86, . p =0.025), and systolic blood pressure (sBP) >100. mmHg at discharge (OR, 4.39; 95% CI 1.39-13.81, . p =0.011). Overall, there were 51 endpoint events [LVRR 11 (21.6%) vs. non-LVRR 40 (49.4%), . p . <. 0.001]. LVRR was a significant predictor of favorable prognosis (HR, 3.77; 95% CI 1.68-8.47, . p . <. 0.001). Notably, 41 (80.4%) patients qualified for early-LVRR. Early-LVRR was associated with better prognosis compared with late-LVRR [early-LVRR 6 (14.6%) vs. late-LVRR 5 (50.0%), . p =0.066]. Among assessed variables, sBP >100. mmHg at discharge was a significant predictor of early-LVRR (OR, 10.87; 95% CI 1.19-100.0, . p =0.034). Conclusion: Prognosis was improved in patients who achieved LVRR. Early-LVRR tended to be an advantage in terms of long-term prognosis. Higher sBP was a predictor not only for all-LVRR but also early-LVRR.

Original languageEnglish
JournalJournal of Cardiology
DOIs
Publication statusAccepted/In press - 2014 Oct 21

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Ventricular Remodeling
Cardiomyopathies
Heart Failure
Blood Pressure
Hospitalization
Stroke Volume

Keywords

  • Blood pressure
  • Cardiomyopathy
  • Predictors
  • Reverse remodeling

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Early vs. late reverse ventricular remodeling in patients with cardiomyopathy. / Banno, Aya; Kohsaka, Shun; Inohara, Taku; Koide, Kimi; Shiraishi, Yasuyuki; Kohno, Takashi; Sano, Motoaki; Yoshikawa, Tsutomu; Fukuda, Keiichi.

In: Journal of Cardiology, 21.10.2014.

Research output: Contribution to journalArticle

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title = "Early vs. late reverse ventricular remodeling in patients with cardiomyopathy",
abstract = "Background: Predictors of left ventricular reverse remodeling (LVRR) and differences in the time taken to achieve LVRR remain unclear. Methods: We consecutively registered 129 patients with severe cardiomyopathy admitted with heart failure (HF). Patients were followed for a median of 778.0 days (IQ: 457.0, 1078.0). LVRR was defined as a decrease in indexed left ventricular systolic dimension of at least 15{\%} additional to a 25{\%} improvement in left ventricular ejection fraction at outpatient check-up compared with discharge. LVRR accomplishment within 400 days was defined as early-LVRR opposing the remaining late-LVRR patients. Primary endpoint was a composite of all-cause mortality and HF re-hospitalization. Results: LVRR was observed in 51 patients (39.5{\%}). Baseline predictors for LVRR were age younger than 60 years (OR, 3.27; 95{\%} CI 1.04-10.37, . p =0.043), no history of previous HF hospitalization (OR, 0.32; 95{\%} CI 0.12-0.86, . p =0.025), and systolic blood pressure (sBP) >100. mmHg at discharge (OR, 4.39; 95{\%} CI 1.39-13.81, . p =0.011). Overall, there were 51 endpoint events [LVRR 11 (21.6{\%}) vs. non-LVRR 40 (49.4{\%}), . p . <. 0.001]. LVRR was a significant predictor of favorable prognosis (HR, 3.77; 95{\%} CI 1.68-8.47, . p . <. 0.001). Notably, 41 (80.4{\%}) patients qualified for early-LVRR. Early-LVRR was associated with better prognosis compared with late-LVRR [early-LVRR 6 (14.6{\%}) vs. late-LVRR 5 (50.0{\%}), . p =0.066]. Among assessed variables, sBP >100. mmHg at discharge was a significant predictor of early-LVRR (OR, 10.87; 95{\%} CI 1.19-100.0, . p =0.034). Conclusion: Prognosis was improved in patients who achieved LVRR. Early-LVRR tended to be an advantage in terms of long-term prognosis. Higher sBP was a predictor not only for all-LVRR but also early-LVRR.",
keywords = "Blood pressure, Cardiomyopathy, Predictors, Reverse remodeling",
author = "Aya Banno and Shun Kohsaka and Taku Inohara and Kimi Koide and Yasuyuki Shiraishi and Takashi Kohno and Motoaki Sano and Tsutomu Yoshikawa and Keiichi Fukuda",
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T1 - Early vs. late reverse ventricular remodeling in patients with cardiomyopathy

AU - Banno, Aya

AU - Kohsaka, Shun

AU - Inohara, Taku

AU - Koide, Kimi

AU - Shiraishi, Yasuyuki

AU - Kohno, Takashi

AU - Sano, Motoaki

AU - Yoshikawa, Tsutomu

AU - Fukuda, Keiichi

PY - 2014/10/21

Y1 - 2014/10/21

N2 - Background: Predictors of left ventricular reverse remodeling (LVRR) and differences in the time taken to achieve LVRR remain unclear. Methods: We consecutively registered 129 patients with severe cardiomyopathy admitted with heart failure (HF). Patients were followed for a median of 778.0 days (IQ: 457.0, 1078.0). LVRR was defined as a decrease in indexed left ventricular systolic dimension of at least 15% additional to a 25% improvement in left ventricular ejection fraction at outpatient check-up compared with discharge. LVRR accomplishment within 400 days was defined as early-LVRR opposing the remaining late-LVRR patients. Primary endpoint was a composite of all-cause mortality and HF re-hospitalization. Results: LVRR was observed in 51 patients (39.5%). Baseline predictors for LVRR were age younger than 60 years (OR, 3.27; 95% CI 1.04-10.37, . p =0.043), no history of previous HF hospitalization (OR, 0.32; 95% CI 0.12-0.86, . p =0.025), and systolic blood pressure (sBP) >100. mmHg at discharge (OR, 4.39; 95% CI 1.39-13.81, . p =0.011). Overall, there were 51 endpoint events [LVRR 11 (21.6%) vs. non-LVRR 40 (49.4%), . p . <. 0.001]. LVRR was a significant predictor of favorable prognosis (HR, 3.77; 95% CI 1.68-8.47, . p . <. 0.001). Notably, 41 (80.4%) patients qualified for early-LVRR. Early-LVRR was associated with better prognosis compared with late-LVRR [early-LVRR 6 (14.6%) vs. late-LVRR 5 (50.0%), . p =0.066]. Among assessed variables, sBP >100. mmHg at discharge was a significant predictor of early-LVRR (OR, 10.87; 95% CI 1.19-100.0, . p =0.034). Conclusion: Prognosis was improved in patients who achieved LVRR. Early-LVRR tended to be an advantage in terms of long-term prognosis. Higher sBP was a predictor not only for all-LVRR but also early-LVRR.

AB - Background: Predictors of left ventricular reverse remodeling (LVRR) and differences in the time taken to achieve LVRR remain unclear. Methods: We consecutively registered 129 patients with severe cardiomyopathy admitted with heart failure (HF). Patients were followed for a median of 778.0 days (IQ: 457.0, 1078.0). LVRR was defined as a decrease in indexed left ventricular systolic dimension of at least 15% additional to a 25% improvement in left ventricular ejection fraction at outpatient check-up compared with discharge. LVRR accomplishment within 400 days was defined as early-LVRR opposing the remaining late-LVRR patients. Primary endpoint was a composite of all-cause mortality and HF re-hospitalization. Results: LVRR was observed in 51 patients (39.5%). Baseline predictors for LVRR were age younger than 60 years (OR, 3.27; 95% CI 1.04-10.37, . p =0.043), no history of previous HF hospitalization (OR, 0.32; 95% CI 0.12-0.86, . p =0.025), and systolic blood pressure (sBP) >100. mmHg at discharge (OR, 4.39; 95% CI 1.39-13.81, . p =0.011). Overall, there were 51 endpoint events [LVRR 11 (21.6%) vs. non-LVRR 40 (49.4%), . p . <. 0.001]. LVRR was a significant predictor of favorable prognosis (HR, 3.77; 95% CI 1.68-8.47, . p . <. 0.001). Notably, 41 (80.4%) patients qualified for early-LVRR. Early-LVRR was associated with better prognosis compared with late-LVRR [early-LVRR 6 (14.6%) vs. late-LVRR 5 (50.0%), . p =0.066]. Among assessed variables, sBP >100. mmHg at discharge was a significant predictor of early-LVRR (OR, 10.87; 95% CI 1.19-100.0, . p =0.034). Conclusion: Prognosis was improved in patients who achieved LVRR. Early-LVRR tended to be an advantage in terms of long-term prognosis. Higher sBP was a predictor not only for all-LVRR but also early-LVRR.

KW - Blood pressure

KW - Cardiomyopathy

KW - Predictors

KW - Reverse remodeling

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