EBV-positive Burkitt lymphoma as a late-onset posttransplantion lymphoproliferative disorder after allogeneic stem cell transplantation

Naohiro Sekiguchi; Junko Nishimoto; Ryuji Tanosaki; Nobuko Kubota; Yukiko Yokota; Yukio Kobayashi; Takashi Watanabe; Masahiro Kami; Yoichi Takaue; Yoshihiro Matsuno; Kensei Tobinai

doi:10.1532/IJH97.03175

EBV-positive Burkitt lymphoma as a late-onset posttransplantion lymphoproliferative disorder after allogeneic stem cell transplantation

Naohiro Sekiguchi, Junko Nishimoto, Ryuji Tanosaki, Nobuko Kubota, Yukiko Yokota, Yukio Kobayashi, Takashi Watanabe, Masahiro Kami, Yoichi Takaue, Yoshihiro Matsuno, Kensei Tobinai

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Posttransplantation lymphoproliferative disorder (PTLD) is one of the well-recognized complications after allogeneic stem cell transplantation (SCT). It generally occurs early after SCT, and only a few reports of late-onset cases are available. We report a 58-year-old male patient who developed lymphoma 4 years after allogeneic SCT for chronic myeloid leukemia. The presence of c-myc translocation and Epstein-Barr virus-encoded RNA in the lymphoma cells, without rearrangement of the 3′-bcr region, confirmed the histopathologic diagnosis of Burkitt lymphoma. DNA chimerism analysis revealed that the lymphoma cells were of donor origin. The patient achieved complete response with intensive chemotherapy. To our knowledge, this is the first report of Burkitt lymphoma as a PTLD occurring after allogeneic SCT.

Original language	English
Pages (from-to)	387-389
Number of pages	3
Journal	International journal of hematology
Volume	79
Issue number	4
DOIs	https://doi.org/10.1532/IJH97.03175
Publication status	Published - 2004 May
Externally published	Yes

Keywords

Allogeneic stem cell transplantation
Burkitt lymphoma
Epstein-Barr virus
PTLD
Posttransplantation lymphoproliferative disorder

ASJC Scopus subject areas

Hematology

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10.1532/IJH97.03175

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Sekiguchi, N., Nishimoto, J., Tanosaki, R., Kubota, N., Yokota, Y., Kobayashi, Y., Watanabe, T., Kami, M., Takaue, Y., Matsuno, Y., & Tobinai, K. (2004). EBV-positive Burkitt lymphoma as a late-onset posttransplantion lymphoproliferative disorder after allogeneic stem cell transplantation. International journal of hematology, 79(4), 387-389. https://doi.org/10.1532/IJH97.03175

Sekiguchi, N, Nishimoto, J, Tanosaki, R, Kubota, N, Yokota, Y, Kobayashi, Y, Watanabe, T, Kami, M, Takaue, Y, Matsuno, Y & Tobinai, K 2004, 'EBV-positive Burkitt lymphoma as a late-onset posttransplantion lymphoproliferative disorder after allogeneic stem cell transplantation', International journal of hematology, vol. 79, no. 4, pp. 387-389. https://doi.org/10.1532/IJH97.03175

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title = "EBV-positive Burkitt lymphoma as a late-onset posttransplantion lymphoproliferative disorder after allogeneic stem cell transplantation",

abstract = "Posttransplantation lymphoproliferative disorder (PTLD) is one of the well-recognized complications after allogeneic stem cell transplantation (SCT). It generally occurs early after SCT, and only a few reports of late-onset cases are available. We report a 58-year-old male patient who developed lymphoma 4 years after allogeneic SCT for chronic myeloid leukemia. The presence of c-myc translocation and Epstein-Barr virus-encoded RNA in the lymphoma cells, without rearrangement of the 3′-bcr region, confirmed the histopathologic diagnosis of Burkitt lymphoma. DNA chimerism analysis revealed that the lymphoma cells were of donor origin. The patient achieved complete response with intensive chemotherapy. To our knowledge, this is the first report of Burkitt lymphoma as a PTLD occurring after allogeneic SCT.",

keywords = "Allogeneic stem cell transplantation, Burkitt lymphoma, Epstein-Barr virus, PTLD, Posttransplantation lymphoproliferative disorder",

author = "Naohiro Sekiguchi and Junko Nishimoto and Ryuji Tanosaki and Nobuko Kubota and Yukiko Yokota and Yukio Kobayashi and Takashi Watanabe and Masahiro Kami and Yoichi Takaue and Yoshihiro Matsuno and Kensei Tobinai",

note = "Funding Information: This study was supported by a Grant-in-Aid for Cancer Research from the Ministry of Health, Labor and Welfare of Japan (15-11) and a Bristol-Myers Squibb Unrestricted Grant.",

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doi = "10.1532/IJH97.03175",

language = "English",

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AU - Sekiguchi, Naohiro

AU - Nishimoto, Junko

AU - Tanosaki, Ryuji

AU - Kubota, Nobuko

AU - Yokota, Yukiko

AU - Kobayashi, Yukio

AU - Watanabe, Takashi

AU - Kami, Masahiro

AU - Takaue, Yoichi

AU - Matsuno, Yoshihiro

AU - Tobinai, Kensei

N1 - Funding Information: This study was supported by a Grant-in-Aid for Cancer Research from the Ministry of Health, Labor and Welfare of Japan (15-11) and a Bristol-Myers Squibb Unrestricted Grant.

PY - 2004/5

Y1 - 2004/5

N2 - Posttransplantation lymphoproliferative disorder (PTLD) is one of the well-recognized complications after allogeneic stem cell transplantation (SCT). It generally occurs early after SCT, and only a few reports of late-onset cases are available. We report a 58-year-old male patient who developed lymphoma 4 years after allogeneic SCT for chronic myeloid leukemia. The presence of c-myc translocation and Epstein-Barr virus-encoded RNA in the lymphoma cells, without rearrangement of the 3′-bcr region, confirmed the histopathologic diagnosis of Burkitt lymphoma. DNA chimerism analysis revealed that the lymphoma cells were of donor origin. The patient achieved complete response with intensive chemotherapy. To our knowledge, this is the first report of Burkitt lymphoma as a PTLD occurring after allogeneic SCT.

AB - Posttransplantation lymphoproliferative disorder (PTLD) is one of the well-recognized complications after allogeneic stem cell transplantation (SCT). It generally occurs early after SCT, and only a few reports of late-onset cases are available. We report a 58-year-old male patient who developed lymphoma 4 years after allogeneic SCT for chronic myeloid leukemia. The presence of c-myc translocation and Epstein-Barr virus-encoded RNA in the lymphoma cells, without rearrangement of the 3′-bcr region, confirmed the histopathologic diagnosis of Burkitt lymphoma. DNA chimerism analysis revealed that the lymphoma cells were of donor origin. The patient achieved complete response with intensive chemotherapy. To our knowledge, this is the first report of Burkitt lymphoma as a PTLD occurring after allogeneic SCT.

KW - Allogeneic stem cell transplantation

KW - Burkitt lymphoma

KW - Epstein-Barr virus

KW - PTLD

KW - Posttransplantation lymphoproliferative disorder

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EBV-positive Burkitt lymphoma as a late-onset posttransplantion lymphoproliferative disorder after allogeneic stem cell transplantation

Abstract

Keywords

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