EBV-positive Burkitt lymphoma as a late-onset posttransplantion lymphoproliferative disorder after allogeneic stem cell transplantation

Naohiro Sekiguchi, Junko Nishimoto, Ryuji Tanosaki, Nobuko Kubota, Yukiko Yokota, Yukio Kobayashi, Takashi Watanabe, Masahiro Kami, Yoichi Takaue, Yoshihiro Matsuno, Kensei Tobinai

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Posttransplantation lymphoproliferative disorder (PTLD) is one of the well-recognized complications after allogeneic stem cell transplantation (SCT). It generally occurs early after SCT, and only a few reports of late-onset cases are available. We report a 58-year-old male patient who developed lymphoma 4 years after allogeneic SCT for chronic myeloid leukemia. The presence of c-myc translocation and Epstein-Barr virus-encoded RNA in the lymphoma cells, without rearrangement of the 3′-bcr region, confirmed the histopathologic diagnosis of Burkitt lymphoma. DNA chimerism analysis revealed that the lymphoma cells were of donor origin. The patient achieved complete response with intensive chemotherapy. To our knowledge, this is the first report of Burkitt lymphoma as a PTLD occurring after allogeneic SCT.

Original languageEnglish
Pages (from-to)387-389
Number of pages3
JournalInternational Journal of Hematology
Volume79
Issue number4
Publication statusPublished - 2004 May
Externally publishedYes

Fingerprint

Burkitt Lymphoma
Lymphoproliferative Disorders
Stem Cell Transplantation
Human Herpesvirus 4
Lymphoma
Chimerism
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Tissue Donors
RNA
Drug Therapy
DNA

Keywords

  • Allogeneic stem cell transplantation
  • Burkitt lymphoma
  • Epstein-Barr virus
  • Posttransplantation lymphoproliferative disorder
  • PTLD

ASJC Scopus subject areas

  • Hematology

Cite this

EBV-positive Burkitt lymphoma as a late-onset posttransplantion lymphoproliferative disorder after allogeneic stem cell transplantation. / Sekiguchi, Naohiro; Nishimoto, Junko; Tanosaki, Ryuji; Kubota, Nobuko; Yokota, Yukiko; Kobayashi, Yukio; Watanabe, Takashi; Kami, Masahiro; Takaue, Yoichi; Matsuno, Yoshihiro; Tobinai, Kensei.

In: International Journal of Hematology, Vol. 79, No. 4, 05.2004, p. 387-389.

Research output: Contribution to journalArticle

Sekiguchi, N, Nishimoto, J, Tanosaki, R, Kubota, N, Yokota, Y, Kobayashi, Y, Watanabe, T, Kami, M, Takaue, Y, Matsuno, Y & Tobinai, K 2004, 'EBV-positive Burkitt lymphoma as a late-onset posttransplantion lymphoproliferative disorder after allogeneic stem cell transplantation', International Journal of Hematology, vol. 79, no. 4, pp. 387-389.
Sekiguchi, Naohiro ; Nishimoto, Junko ; Tanosaki, Ryuji ; Kubota, Nobuko ; Yokota, Yukiko ; Kobayashi, Yukio ; Watanabe, Takashi ; Kami, Masahiro ; Takaue, Yoichi ; Matsuno, Yoshihiro ; Tobinai, Kensei. / EBV-positive Burkitt lymphoma as a late-onset posttransplantion lymphoproliferative disorder after allogeneic stem cell transplantation. In: International Journal of Hematology. 2004 ; Vol. 79, No. 4. pp. 387-389.
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