EBV-positive Burkitt lymphoma as a late-onset posttransplantion lymphoproliferative disorder after allogeneic stem cell transplantation

Naohiro Sekiguchi, Junko Nishimoto, Ryuji Tanosaki, Nobuko Kubota, Yukiko Yokota, Yukio Kobayashi, Takashi Watanabe, Masahiro Kami, Yoichi Takaue, Yoshihiro Matsuno, Kensei Tobinai

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5 Citations (Scopus)

Abstract

Posttransplantation lymphoproliferative disorder (PTLD) is one of the well-recognized complications after allogeneic stem cell transplantation (SCT). It generally occurs early after SCT, and only a few reports of late-onset cases are available. We report a 58-year-old male patient who developed lymphoma 4 years after allogeneic SCT for chronic myeloid leukemia. The presence of c-myc translocation and Epstein-Barr virus-encoded RNA in the lymphoma cells, without rearrangement of the 3′-bcr region, confirmed the histopathologic diagnosis of Burkitt lymphoma. DNA chimerism analysis revealed that the lymphoma cells were of donor origin. The patient achieved complete response with intensive chemotherapy. To our knowledge, this is the first report of Burkitt lymphoma as a PTLD occurring after allogeneic SCT.

Original languageEnglish
Pages (from-to)387-389
Number of pages3
JournalInternational journal of hematology
Volume79
Issue number4
DOIs
Publication statusPublished - 2004 May
Externally publishedYes

Keywords

  • Allogeneic stem cell transplantation
  • Burkitt lymphoma
  • Epstein-Barr virus
  • PTLD
  • Posttransplantation lymphoproliferative disorder

ASJC Scopus subject areas

  • Hematology

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  • Cite this

    Sekiguchi, N., Nishimoto, J., Tanosaki, R., Kubota, N., Yokota, Y., Kobayashi, Y., Watanabe, T., Kami, M., Takaue, Y., Matsuno, Y., & Tobinai, K. (2004). EBV-positive Burkitt lymphoma as a late-onset posttransplantion lymphoproliferative disorder after allogeneic stem cell transplantation. International journal of hematology, 79(4), 387-389. https://doi.org/10.1532/IJH97.03175