Echinodermata: The complex immune system in echinoderms

L. Courtney Smith, Vincenzo Arizza, Megan A. Barela Hudgell, Gianpaolo Barone, Andrea G. Bodnar, Katherine M. Buckley, Vincenzo Cunsolo, Nolwenn M. Dheilly, Nicola Franchi, Sebastian D. Fugmann, Ryohei Furukawa, Jose Garcia-Arraras, John H. Henson, Taku Hibino, Zoe H. Irons, Chun Li, Cheng Man Lun, Audrey J. Majeske, Matan Oren, Patrizia PagliaraAnnalisa Pinsino, David A. Raftos, Jonathan P. Rast, Bakary Samasa, Domenico Schillaci, Catherine S. Schrankel, Loredana Stabili, Klara Stensväg, Elisse Sutton

Research output: Chapter in Book/Report/Conference proceedingChapter

11 Citations (Scopus)

Abstract

The Echinodermata are an ancient phylum of benthic marine invertebrates with a dispersal-stage planktonic larva. These animals have innate immune systems characterized initially by clearance of foreign particles, including microbes, from the body cavity of both larvae and adults, and allograft tissue rejection in adults. Immune responsiveness is mediated by a variety of adult coelomocytes and larval mesenchyme cells. Echinoderm diseases from a range of pathogens can lead to mass die-offs and impact aquaculture, but some individuals can recover. Genome sequences of several echinoderms have identified genes with immune function, including expanded families of Toll-like receptors, NOD-like receptors, and scavenger receptors with cysteine-rich domains, plus signaling pathways and cytokines. The set of transcription factors that regulate proliferation and differentiation of the cellular immune system are conserved and indicate the ancestral origins of hematopoiesis. Both larval and adult echinoderms are in constant contact with potential pathogens in seawater, and they respond to infection by phagocytosis and encapsulation, and employ proteins that function in immune detection and response. Antipathogen responses include activation of the SpTransformer genes, a complement system, and the production of many types of antimicrobial peptides. Echinoderms have homologues of the recombinase activating genes plus all associated genes that function in vertebrates for immunoglobulin gene family rearrangement, although their gene targets are unknown. The echinoderm immune system has been characterized as unexpectedly complex, robust, and flexible. Many echinoderms have very long life-spans that correlate with an excellent capacity for cell damage repair. In many marine ecosystems, echinoderms are keystone predators and herbivores, and therefore are species that can serve as optimal sentinels of environmental health. Coelomocytes can be employed in sensor systems to test for the presence of marine pollutants. When Elie Metchnikoff inserted a rose prickle into a larval sea star and observed chemotaxis, phagocytosis, and encapsulation by the mesenchyme cells, he initiated not only the field of immunology but also that of comparative immunology, of which the echinoderms have been an important part.

Original languageEnglish
Title of host publicationAdvances in Comparative Immunology
PublisherSpringer International Publishing
Pages409-501
Number of pages93
ISBN (Electronic)9783319767680
ISBN (Print)9783319767673
DOIs
Publication statusPublished - 2018 Jan 1

Fingerprint

Echinodermata
immune system
Immune System
Mesoderm
Allergy and Immunology
Phagocytosis
Genes
Larva
Starfish
Scavenger Receptors
Aquaculture
Immunoglobulin Genes
Recombinases
Herbivory
Environmental Health
Gene Rearrangement
Toll-Like Receptors
Hematopoiesis
Seawater
Chemotaxis

Keywords

  • Asteroidea
  • Brittle stars
  • Coelomocytes
  • Crinoidea
  • Diseases
  • Echinoidea
  • Genomics
  • Holothuroidea
  • Immune development
  • Immune responses
  • Immuno-toxicology
  • Larval immune cells
  • Ophiuroidea
  • Proteomics
  • Sea cucumbers
  • Sea lilies
  • Sea stars
  • Sea urchins
  • Senescence

ASJC Scopus subject areas

  • Medicine(all)
  • Immunology and Microbiology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Courtney Smith, L., Arizza, V., Barela Hudgell, M. A., Barone, G., Bodnar, A. G., Buckley, K. M., ... Sutton, E. (2018). Echinodermata: The complex immune system in echinoderms. In Advances in Comparative Immunology (pp. 409-501). Springer International Publishing. https://doi.org/10.1007/978-3-319-76768-0_13

Echinodermata : The complex immune system in echinoderms. / Courtney Smith, L.; Arizza, Vincenzo; Barela Hudgell, Megan A.; Barone, Gianpaolo; Bodnar, Andrea G.; Buckley, Katherine M.; Cunsolo, Vincenzo; Dheilly, Nolwenn M.; Franchi, Nicola; Fugmann, Sebastian D.; Furukawa, Ryohei; Garcia-Arraras, Jose; Henson, John H.; Hibino, Taku; Irons, Zoe H.; Li, Chun; Lun, Cheng Man; Majeske, Audrey J.; Oren, Matan; Pagliara, Patrizia; Pinsino, Annalisa; Raftos, David A.; Rast, Jonathan P.; Samasa, Bakary; Schillaci, Domenico; Schrankel, Catherine S.; Stabili, Loredana; Stensväg, Klara; Sutton, Elisse.

Advances in Comparative Immunology. Springer International Publishing, 2018. p. 409-501.

Research output: Chapter in Book/Report/Conference proceedingChapter

Courtney Smith, L, Arizza, V, Barela Hudgell, MA, Barone, G, Bodnar, AG, Buckley, KM, Cunsolo, V, Dheilly, NM, Franchi, N, Fugmann, SD, Furukawa, R, Garcia-Arraras, J, Henson, JH, Hibino, T, Irons, ZH, Li, C, Lun, CM, Majeske, AJ, Oren, M, Pagliara, P, Pinsino, A, Raftos, DA, Rast, JP, Samasa, B, Schillaci, D, Schrankel, CS, Stabili, L, Stensväg, K & Sutton, E 2018, Echinodermata: The complex immune system in echinoderms. in Advances in Comparative Immunology. Springer International Publishing, pp. 409-501. https://doi.org/10.1007/978-3-319-76768-0_13
Courtney Smith L, Arizza V, Barela Hudgell MA, Barone G, Bodnar AG, Buckley KM et al. Echinodermata: The complex immune system in echinoderms. In Advances in Comparative Immunology. Springer International Publishing. 2018. p. 409-501 https://doi.org/10.1007/978-3-319-76768-0_13
Courtney Smith, L. ; Arizza, Vincenzo ; Barela Hudgell, Megan A. ; Barone, Gianpaolo ; Bodnar, Andrea G. ; Buckley, Katherine M. ; Cunsolo, Vincenzo ; Dheilly, Nolwenn M. ; Franchi, Nicola ; Fugmann, Sebastian D. ; Furukawa, Ryohei ; Garcia-Arraras, Jose ; Henson, John H. ; Hibino, Taku ; Irons, Zoe H. ; Li, Chun ; Lun, Cheng Man ; Majeske, Audrey J. ; Oren, Matan ; Pagliara, Patrizia ; Pinsino, Annalisa ; Raftos, David A. ; Rast, Jonathan P. ; Samasa, Bakary ; Schillaci, Domenico ; Schrankel, Catherine S. ; Stabili, Loredana ; Stensväg, Klara ; Sutton, Elisse. / Echinodermata : The complex immune system in echinoderms. Advances in Comparative Immunology. Springer International Publishing, 2018. pp. 409-501
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AU - Bodnar, Andrea G.

AU - Buckley, Katherine M.

AU - Cunsolo, Vincenzo

AU - Dheilly, Nolwenn M.

AU - Franchi, Nicola

AU - Fugmann, Sebastian D.

AU - Furukawa, Ryohei

AU - Garcia-Arraras, Jose

AU - Henson, John H.

AU - Hibino, Taku

AU - Irons, Zoe H.

AU - Li, Chun

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AU - Samasa, Bakary

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N2 - The Echinodermata are an ancient phylum of benthic marine invertebrates with a dispersal-stage planktonic larva. These animals have innate immune systems characterized initially by clearance of foreign particles, including microbes, from the body cavity of both larvae and adults, and allograft tissue rejection in adults. Immune responsiveness is mediated by a variety of adult coelomocytes and larval mesenchyme cells. Echinoderm diseases from a range of pathogens can lead to mass die-offs and impact aquaculture, but some individuals can recover. Genome sequences of several echinoderms have identified genes with immune function, including expanded families of Toll-like receptors, NOD-like receptors, and scavenger receptors with cysteine-rich domains, plus signaling pathways and cytokines. The set of transcription factors that regulate proliferation and differentiation of the cellular immune system are conserved and indicate the ancestral origins of hematopoiesis. Both larval and adult echinoderms are in constant contact with potential pathogens in seawater, and they respond to infection by phagocytosis and encapsulation, and employ proteins that function in immune detection and response. Antipathogen responses include activation of the SpTransformer genes, a complement system, and the production of many types of antimicrobial peptides. Echinoderms have homologues of the recombinase activating genes plus all associated genes that function in vertebrates for immunoglobulin gene family rearrangement, although their gene targets are unknown. The echinoderm immune system has been characterized as unexpectedly complex, robust, and flexible. Many echinoderms have very long life-spans that correlate with an excellent capacity for cell damage repair. In many marine ecosystems, echinoderms are keystone predators and herbivores, and therefore are species that can serve as optimal sentinels of environmental health. Coelomocytes can be employed in sensor systems to test for the presence of marine pollutants. When Elie Metchnikoff inserted a rose prickle into a larval sea star and observed chemotaxis, phagocytosis, and encapsulation by the mesenchyme cells, he initiated not only the field of immunology but also that of comparative immunology, of which the echinoderms have been an important part.

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KW - Asteroidea

KW - Brittle stars

KW - Coelomocytes

KW - Crinoidea

KW - Diseases

KW - Echinoidea

KW - Genomics

KW - Holothuroidea

KW - Immune development

KW - Immune responses

KW - Immuno-toxicology

KW - Larval immune cells

KW - Ophiuroidea

KW - Proteomics

KW - Sea cucumbers

KW - Sea lilies

KW - Sea stars

KW - Sea urchins

KW - Senescence

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