Ecological and immunopathological implications of oral bacteria in helicobacter pylori-infected disease

Katsuji Okuda, Ryuta Kimizuka, Akira Katakura, Taneaki Nakagawa, Kazuyuki Ishihara

Research output: Contribution to journalReview article

29 Citations (Scopus)

Abstract

Increasing evidence has linked colonization by Helicobacter pylori with the development of gastritis and peptic ulcer disease. H. pylori resides primarily in the gastric mucosa without invading the gastric epithelium, causing persistent mild gastric inflammation. There are many reports examining the relationship between colonization by microorganisms in the stomach and oral cavity. We found that some oral bacteria are able to trap H. pylori cells, but oral bacteria inhibit H. pylori growth in vitro. In cases where H. pylori was detected in oral cavity samples, including oral cancer surface samples, we suggested that this species had colonized the stomach and were present in the oral cavity only as a transient organism. We demonstrated that periodontopathic Campylobacter rectus strains posses proteinaceous antigens, including heat shock proteins that share antigenicity with antigens of H. pylori strains. These cross-reactive antigens between H. pylori and C rectus may be related to the induction of immunopathological responses in periodontal tissues and the stomach. We concluded that H. pylori could not survive in the human oral cavity; however, there would be an interrelationship between periodontal disease due to C rectus and stomach diseases due to H. pylori.

Original languageEnglish
Pages (from-to)123-128
Number of pages6
JournalJournal of Periodontology
Volume74
Issue number1
DOIs
Publication statusPublished - 2003 Jan 1
Externally publishedYes

Keywords

  • Campylobacter rectus
  • Helicobacter pylori
  • Immune response
  • Oral cavity/microbiology
  • Peridontal diseases/microbiology
  • Stomach diseases/microbiology

ASJC Scopus subject areas

  • Periodontics

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