Ecological and immunopathological implications of oral bacteria in helicobacter pylori-infected disease

Katsuji Okuda, Ryuta Kimizuka, Akira Katakura, Taneaki Nakagawa, Kazuyuki Ishihara

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Increasing evidence has linked colonization by Helicobacter pylori with the development of gastritis and peptic ulcer disease. H. pylori resides primarily in the gastric mucosa without invading the gastric epithelium, causing persistent mild gastric inflammation. There are many reports examining the relationship between colonization by microorganisms in the stomach and oral cavity. We found that some oral bacteria are able to trap H. pylori cells, but oral bacteria inhibit H. pylori growth in vitro. In cases where H. pylori was detected in oral cavity samples, including oral cancer surface samples, we suggested that this species had colonized the stomach and were present in the oral cavity only as a transient organism. We demonstrated that periodontopathic Campylobacter rectus strains posses proteinaceous antigens, including heat shock proteins that share antigenicity with antigens of H. pylori strains. These cross-reactive antigens between H. pylori and C rectus may be related to the induction of immunopathological responses in periodontal tissues and the stomach. We concluded that H. pylori could not survive in the human oral cavity; however, there would be an interrelationship between periodontal disease due to C rectus and stomach diseases due to H. pylori.

Original languageEnglish
Pages (from-to)123-128
Number of pages6
JournalJournal of Periodontology
Volume74
Issue number1
DOIs
Publication statusPublished - 2003 Jan 1
Externally publishedYes

Fingerprint

Helicobacter pylori
Bacteria
Stomach
Mouth
Antigens
Campylobacter rectus
Stomach Diseases
Mouth Neoplasms
Periodontal Diseases
Gastritis
Heat-Shock Proteins
Gastric Mucosa
Peptic Ulcer
Epithelium
Inflammation
Growth

Keywords

  • Campylobacter rectus
  • Helicobacter pylori
  • Immune response
  • Oral cavity/microbiology
  • Peridontal diseases/microbiology
  • Stomach diseases/microbiology

ASJC Scopus subject areas

  • Dentistry(all)

Cite this

Ecological and immunopathological implications of oral bacteria in helicobacter pylori-infected disease. / Okuda, Katsuji; Kimizuka, Ryuta; Katakura, Akira; Nakagawa, Taneaki; Ishihara, Kazuyuki.

In: Journal of Periodontology, Vol. 74, No. 1, 01.01.2003, p. 123-128.

Research output: Contribution to journalArticle

Okuda, Katsuji ; Kimizuka, Ryuta ; Katakura, Akira ; Nakagawa, Taneaki ; Ishihara, Kazuyuki. / Ecological and immunopathological implications of oral bacteria in helicobacter pylori-infected disease. In: Journal of Periodontology. 2003 ; Vol. 74, No. 1. pp. 123-128.
@article{3f559069f3f34acf9729225b3e039751,
title = "Ecological and immunopathological implications of oral bacteria in helicobacter pylori-infected disease",
abstract = "Increasing evidence has linked colonization by Helicobacter pylori with the development of gastritis and peptic ulcer disease. H. pylori resides primarily in the gastric mucosa without invading the gastric epithelium, causing persistent mild gastric inflammation. There are many reports examining the relationship between colonization by microorganisms in the stomach and oral cavity. We found that some oral bacteria are able to trap H. pylori cells, but oral bacteria inhibit H. pylori growth in vitro. In cases where H. pylori was detected in oral cavity samples, including oral cancer surface samples, we suggested that this species had colonized the stomach and were present in the oral cavity only as a transient organism. We demonstrated that periodontopathic Campylobacter rectus strains posses proteinaceous antigens, including heat shock proteins that share antigenicity with antigens of H. pylori strains. These cross-reactive antigens between H. pylori and C rectus may be related to the induction of immunopathological responses in periodontal tissues and the stomach. We concluded that H. pylori could not survive in the human oral cavity; however, there would be an interrelationship between periodontal disease due to C rectus and stomach diseases due to H. pylori.",
keywords = "Campylobacter rectus, Helicobacter pylori, Immune response, Oral cavity/microbiology, Peridontal diseases/microbiology, Stomach diseases/microbiology",
author = "Katsuji Okuda and Ryuta Kimizuka and Akira Katakura and Taneaki Nakagawa and Kazuyuki Ishihara",
year = "2003",
month = "1",
day = "1",
doi = "10.1902/jop.2003.74.1.123",
language = "English",
volume = "74",
pages = "123--128",
journal = "Journal of Periodontology",
issn = "0022-3492",
publisher = "American Academy of Periodontology",
number = "1",

}

TY - JOUR

T1 - Ecological and immunopathological implications of oral bacteria in helicobacter pylori-infected disease

AU - Okuda, Katsuji

AU - Kimizuka, Ryuta

AU - Katakura, Akira

AU - Nakagawa, Taneaki

AU - Ishihara, Kazuyuki

PY - 2003/1/1

Y1 - 2003/1/1

N2 - Increasing evidence has linked colonization by Helicobacter pylori with the development of gastritis and peptic ulcer disease. H. pylori resides primarily in the gastric mucosa without invading the gastric epithelium, causing persistent mild gastric inflammation. There are many reports examining the relationship between colonization by microorganisms in the stomach and oral cavity. We found that some oral bacteria are able to trap H. pylori cells, but oral bacteria inhibit H. pylori growth in vitro. In cases where H. pylori was detected in oral cavity samples, including oral cancer surface samples, we suggested that this species had colonized the stomach and were present in the oral cavity only as a transient organism. We demonstrated that periodontopathic Campylobacter rectus strains posses proteinaceous antigens, including heat shock proteins that share antigenicity with antigens of H. pylori strains. These cross-reactive antigens between H. pylori and C rectus may be related to the induction of immunopathological responses in periodontal tissues and the stomach. We concluded that H. pylori could not survive in the human oral cavity; however, there would be an interrelationship between periodontal disease due to C rectus and stomach diseases due to H. pylori.

AB - Increasing evidence has linked colonization by Helicobacter pylori with the development of gastritis and peptic ulcer disease. H. pylori resides primarily in the gastric mucosa without invading the gastric epithelium, causing persistent mild gastric inflammation. There are many reports examining the relationship between colonization by microorganisms in the stomach and oral cavity. We found that some oral bacteria are able to trap H. pylori cells, but oral bacteria inhibit H. pylori growth in vitro. In cases where H. pylori was detected in oral cavity samples, including oral cancer surface samples, we suggested that this species had colonized the stomach and were present in the oral cavity only as a transient organism. We demonstrated that periodontopathic Campylobacter rectus strains posses proteinaceous antigens, including heat shock proteins that share antigenicity with antigens of H. pylori strains. These cross-reactive antigens between H. pylori and C rectus may be related to the induction of immunopathological responses in periodontal tissues and the stomach. We concluded that H. pylori could not survive in the human oral cavity; however, there would be an interrelationship between periodontal disease due to C rectus and stomach diseases due to H. pylori.

KW - Campylobacter rectus

KW - Helicobacter pylori

KW - Immune response

KW - Oral cavity/microbiology

KW - Peridontal diseases/microbiology

KW - Stomach diseases/microbiology

UR - http://www.scopus.com/inward/record.url?scp=0037261998&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037261998&partnerID=8YFLogxK

U2 - 10.1902/jop.2003.74.1.123

DO - 10.1902/jop.2003.74.1.123

M3 - Article

VL - 74

SP - 123

EP - 128

JO - Journal of Periodontology

JF - Journal of Periodontology

SN - 0022-3492

IS - 1

ER -