Ectasis and pallor of peripheral airways during mechanical ventilation

Junzo Takeda, Mitsuru Tanaka, Muneaki Shimada, Ryoichi Ochiai, Kazuaki Fukushima, Eiichi Kohoda

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


Study Objective: To evaluate morphologic changes in peripheral airways associated with positive-pressure ventilation (PPV). Design: Single-blind study. Setting: Intensive care unit of a university hospital. Patients: Ten patients who required mechanical ventilation due to acute respiratory failure but had no history of prior pulmonary disease. Interventions: Seventeen fiberoptic bronchoscopy procedures were performed using a fine fiberoptic bronchoscope of 1.8 mm outside diameter. Measurements and Main Results: The main morphologic findings were pallor and ectasts. Increased secretions, pigmentation, and stenosis or collapse in peripheral airways also were observed. Patients with ectasis were more likely to have had prolonged mechanical ventilation (17 ± 9 days) as compared with those patients without ectasis (9 ±5 days). Conclusion: The structural alterations in peripheral airways noted in patients on prolonged PPV suggest that barotrauma may be more widespread than previously recognized.

Original languageEnglish
Pages (from-to)145-149
Number of pages5
JournalJournal of Clinical Anesthesia
Issue number2
Publication statusPublished - 1993


  • Airway, peripheral
  • barotrauma
  • bronchiolectasis
  • bronchoscopy
  • fiberoptics
  • respiratory insufficiency, acute

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine


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