Effect of α-tocopherol status on α-tocopherol transfer protein expression and its messenger RNA level in rat liver

Han Suk Kim; Hiroyuki Arai; Makoto Arita; Yuji Sato; Tohru Ogihara; Keizo Inoue; Makoto Mino; Hiroshi Tamai

doi:10.3109/10715769809097879

Effect of α-tocopherol status on α-tocopherol transfer protein expression and its messenger RNA level in rat liver

Han Suk Kim, Hiroyuki Arai, Makoto Arita, Yuji Sato, Tohru Ogihara, Keizo Inoue, Makoto Mino, Hiroshi Tamai

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

Studies were designed to explore the role of vitamin E nutritional status in regulating the synthesis of α-tocopherol transfer protein (αTTP) in rat liver. In vitamin E-replete rats, expression of this protein and its specific messenger RNA (mRNA) was decreased by about 300% compared with rats with normal vitamin E levels. In vitamin E-depleted rats, the αTTP-specific mRNA level increased to about 150% of that in the normal vitamin E group. However, protein expression remained constant. These findings indicate that the synthesis of αTTP can be regulated by the vitamin E nutritional status.

Original language	English
Pages (from-to)	87-92
Number of pages	6
Journal	Free Radical Research
Volume	28
Issue number	1
DOIs	https://doi.org/10.3109/10715769809097879
Publication status	Published - 1998
Externally published	Yes

Keywords

Effect of nutritional status
Gene expression
Messenger RNA
Vitamin E
α-tocopherol transfer protein

ASJC Scopus subject areas

Biochemistry

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10.3109/10715769809097879

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abstract = "Studies were designed to explore the role of vitamin E nutritional status in regulating the synthesis of α-tocopherol transfer protein (αTTP) in rat liver. In vitamin E-replete rats, expression of this protein and its specific messenger RNA (mRNA) was decreased by about 300% compared with rats with normal vitamin E levels. In vitamin E-depleted rats, the αTTP-specific mRNA level increased to about 150% of that in the normal vitamin E group. However, protein expression remained constant. These findings indicate that the synthesis of αTTP can be regulated by the vitamin E nutritional status.",

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AU - Kim, Han Suk

AU - Arai, Hiroyuki

AU - Arita, Makoto

AU - Sato, Yuji

AU - Ogihara, Tohru

AU - Inoue, Keizo

AU - Mino, Makoto

AU - Tamai, Hiroshi

PY - 1998

Y1 - 1998

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AB - Studies were designed to explore the role of vitamin E nutritional status in regulating the synthesis of α-tocopherol transfer protein (αTTP) in rat liver. In vitamin E-replete rats, expression of this protein and its specific messenger RNA (mRNA) was decreased by about 300% compared with rats with normal vitamin E levels. In vitamin E-depleted rats, the αTTP-specific mRNA level increased to about 150% of that in the normal vitamin E group. However, protein expression remained constant. These findings indicate that the synthesis of αTTP can be regulated by the vitamin E nutritional status.

KW - Effect of nutritional status

KW - Gene expression

KW - Messenger RNA

KW - Vitamin E

KW - α-tocopherol transfer protein

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Effect of α-tocopherol status on α-tocopherol transfer protein expression and its messenger RNA level in rat liver

Abstract

Keywords

ASJC Scopus subject areas

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