Effect of α-tocopherol status on α-tocopherol transfer protein expression and its messenger RNA level in rat liver

Han Suk Kim, Hiroyuki Arai, Makoto Arita, Yuji Sato, Tohru Ogihara, Keizo Inoue, Makoto Mino, Hiroshi Tamai

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Studies were designed to explore the role of vitamin E nutritional status in regulating the synthesis of α-tocopherol transfer protein (αTTP) in rat liver. In vitamin E-replete rats, expression of this protein and its specific messenger RNA (mRNA) was decreased by about 300% compared with rats with normal vitamin E levels. In vitamin E-depleted rats, the αTTP-specific mRNA level increased to about 150% of that in the normal vitamin E group. However, protein expression remained constant. These findings indicate that the synthesis of αTTP can be regulated by the vitamin E nutritional status.

Original languageEnglish
Pages (from-to)87-92
Number of pages6
JournalFree Radical Research
Volume28
Issue number1
Publication statusPublished - 1998 Apr 23
Externally publishedYes

Keywords

  • Effect of nutritional status
  • Gene expression
  • Messenger RNA
  • Vitamin E
  • α-tocopherol transfer protein

ASJC Scopus subject areas

  • Biochemistry

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    Kim, H. S., Arai, H., Arita, M., Sato, Y., Ogihara, T., Inoue, K., Mino, M., & Tamai, H. (1998). Effect of α-tocopherol status on α-tocopherol transfer protein expression and its messenger RNA level in rat liver. Free Radical Research, 28(1), 87-92.