Effect of anti-attention-deficit hyperactivity disorder (ADHD) medication on clinical seizures and sleep EEG: A retrospective study of Japanese children with ADHD

Hisako Yamamoto, Eiji Nakagawa, Yousuke Kita, Yoshimi Kaga, Masumi Inagaki

Research output: Contribution to journalArticlepeer-review

Abstract

Aims: Patients with attention-deficit hyperactivity disorder (ADHD) often exhibit basic or paroxysmal wave abnormalities on electroencephalography (EEG). Methylphenidate (MPH), an anti-ADHD stimulant, has been reported to lower the seizure threshold. However, there have been no reports comparing EEG changes before and after administration of the central nervous system (CNS) stimulant MPH, or atomoxetine (ATX) hydrochloride, a non-CNS stimulant. In this study, we investigated changes in sleep EEG before and after the administration of ADHD treatment drugs. Method: With the approval of the ethics committee, the medical records of 28 children with ADHD (23 men and 5 women) who gave consent were retrospectively investigated. The appearance of sudden abnormal waves during a 10-minute sleep EEG recording was measured in 0.1-second units, and the duration of these waves was calculated as the paroxysmal index (PI). Results: Paroxysmal index did not differ significantly between patients who received MPH and those who received ATX. In addition, there were no exacerbations of clinical seizures. Conclusion: It was concluded that ADHD medications do not have an adverse effect on epileptic seizures or abnormal sleep EEGs.

Original languageEnglish
Pages (from-to)511-521
Number of pages11
JournalNeuropsychopharmacology Reports
Volume41
Issue number4
DOIs
Publication statusPublished - 2021 Dec
Externally publishedYes

Keywords

  • anti-ADHD drugs
  • atomoxetine
  • attention-deficit hyperactivity disorder
  • EEG
  • epilepsy
  • methylphenidate

ASJC Scopus subject areas

  • Clinical Psychology
  • Pharmacology
  • Psychiatry and Mental health
  • Pharmacology (medical)

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