Effect of body mass index <20 kg/m2 on events in patients who underwent transcatheter aortic valve replacement

Masanori Yamamoto, Kentaro Hayashida, Yusuke Watanabe, Gauthier Mouillet, Thomas Hovasse, Bernard Chevalier, Atsushi Oguri, Jean Luc Dubois-Randé, Marie Claude Morice, Thierry Lefèvre, Emmanuel Teiger

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The Valve Academic Research Consortium-2 has defined body mass index (BMI) <20 as indicative of frailty, which may be one of the co-morbidities not captured by traditional risk factors after transcatheter aortic valve replacement (TAVR). This study aimed to assess the impact of low BMI on clinical outcomes after TAVR. A total of 777 consecutive patients scheduled for TAVR were classified into 3 groups as BMI <20 (n = 56), 20 to 24.9 (n = 322), and ≥25 (n = 399). Procedural complications and clinical outcomes were compared among the 3 groups. They were also analyzed according to propensity-matching model A (BMI <20 [n = 50] vs ≥20 [n = 50]), model B (BMI <20 [n = 50] vs 20 to 24.9 [n = 50]), and model C (BMI <20 [n = 47] vs ≥25 [n = 47]). The differences in baseline characteristics among the 3 groups were adequately adjusted in 3 matched models. Valve Academic Research Consortium-2-defined end points and other complications were similar among the 3 groups in each model. Kaplan-Meier curves indicated no significant differences in cumulative 30-day survival (BMI <20 [91.0%] vs 20 to 24.9 [86.3%], p = 0.33; BMI <20 [91.0%] vs ≥25 [91.4%], p = 0.91, respectively) and 1-year survival (BMI <20 [74.3%] vs 20 to 24.9 [71.8%], p = 0.71; BMI <20 [74.3%] vs ≥25 [77.0%], p = 0.71; respectively). These survival rates were also similar in each of the 3 matched models. In conclusion, BMI <20 was not associated with increased early or midterm mortality. BMI <20 alone may not constitute an additional co-morbidity factor in patients who underwent TAVR.

Original languageEnglish
Pages (from-to)227-233
Number of pages7
JournalAmerican Journal of Cardiology
Volume115
Issue number2
DOIs
Publication statusPublished - 2015 Jan 15
Externally publishedYes

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Body Mass Index
Transcatheter Aortic Valve Replacement
Morbidity
Survival
Research
Survival Rate
Mortality

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Medicine(all)

Cite this

Yamamoto, M., Hayashida, K., Watanabe, Y., Mouillet, G., Hovasse, T., Chevalier, B., ... Teiger, E. (2015). Effect of body mass index <20 kg/m2 on events in patients who underwent transcatheter aortic valve replacement. American Journal of Cardiology, 115(2), 227-233. https://doi.org/10.1016/j.amjcard.2014.10.026

Effect of body mass index <20 kg/m2 on events in patients who underwent transcatheter aortic valve replacement. / Yamamoto, Masanori; Hayashida, Kentaro; Watanabe, Yusuke; Mouillet, Gauthier; Hovasse, Thomas; Chevalier, Bernard; Oguri, Atsushi; Dubois-Randé, Jean Luc; Morice, Marie Claude; Lefèvre, Thierry; Teiger, Emmanuel.

In: American Journal of Cardiology, Vol. 115, No. 2, 15.01.2015, p. 227-233.

Research output: Contribution to journalArticle

Yamamoto, M, Hayashida, K, Watanabe, Y, Mouillet, G, Hovasse, T, Chevalier, B, Oguri, A, Dubois-Randé, JL, Morice, MC, Lefèvre, T & Teiger, E 2015, 'Effect of body mass index <20 kg/m2 on events in patients who underwent transcatheter aortic valve replacement', American Journal of Cardiology, vol. 115, no. 2, pp. 227-233. https://doi.org/10.1016/j.amjcard.2014.10.026
Yamamoto, Masanori ; Hayashida, Kentaro ; Watanabe, Yusuke ; Mouillet, Gauthier ; Hovasse, Thomas ; Chevalier, Bernard ; Oguri, Atsushi ; Dubois-Randé, Jean Luc ; Morice, Marie Claude ; Lefèvre, Thierry ; Teiger, Emmanuel. / Effect of body mass index <20 kg/m2 on events in patients who underwent transcatheter aortic valve replacement. In: American Journal of Cardiology. 2015 ; Vol. 115, No. 2. pp. 227-233.
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abstract = "The Valve Academic Research Consortium-2 has defined body mass index (BMI) <20 as indicative of frailty, which may be one of the co-morbidities not captured by traditional risk factors after transcatheter aortic valve replacement (TAVR). This study aimed to assess the impact of low BMI on clinical outcomes after TAVR. A total of 777 consecutive patients scheduled for TAVR were classified into 3 groups as BMI <20 (n = 56), 20 to 24.9 (n = 322), and ≥25 (n = 399). Procedural complications and clinical outcomes were compared among the 3 groups. They were also analyzed according to propensity-matching model A (BMI <20 [n = 50] vs ≥20 [n = 50]), model B (BMI <20 [n = 50] vs 20 to 24.9 [n = 50]), and model C (BMI <20 [n = 47] vs ≥25 [n = 47]). The differences in baseline characteristics among the 3 groups were adequately adjusted in 3 matched models. Valve Academic Research Consortium-2-defined end points and other complications were similar among the 3 groups in each model. Kaplan-Meier curves indicated no significant differences in cumulative 30-day survival (BMI <20 [91.0{\%}] vs 20 to 24.9 [86.3{\%}], p = 0.33; BMI <20 [91.0{\%}] vs ≥25 [91.4{\%}], p = 0.91, respectively) and 1-year survival (BMI <20 [74.3{\%}] vs 20 to 24.9 [71.8{\%}], p = 0.71; BMI <20 [74.3{\%}] vs ≥25 [77.0{\%}], p = 0.71; respectively). These survival rates were also similar in each of the 3 matched models. In conclusion, BMI <20 was not associated with increased early or midterm mortality. BMI <20 alone may not constitute an additional co-morbidity factor in patients who underwent TAVR.",
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AU - Hovasse, Thomas

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