Effect of CCK-B Gastrin Receptor Antagonist on Pepsinogen-Producing Cells During Omeprazole Treatment

N. Kakei, M. Ichinose, M. Tatematsu, M. Shimizu, S. Ishihama, N. Yahagi, M. Matsushima, H. Fukamachi, K. Miki, K. Kurokawa

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Abstract

The present study investigated the effect of long-term treatment with omeprazole on pepsinogen-producing cells and examined whether the selective CCK-B/gastrin receptor antagonist was able to prevent the omeprazole-induced changes, if occurred, in rat stomach. Rats were treated with omeprazole and/or the CCK-B/gastrin receptor antagonist for 28 days. As a result, omeprazole markedly reduced mucosal pepsinogen activity and its mRNA concentration in rat stomach. Morphologically, in fundic glands omeprazole drastically decreased the proportion of mature chief cells and reciprocally increased that of immature chief cells which were positive for class III mucin. These effects of omeprazole were attenuated by an addition of the CCK-B/gastrin receptor antagonist. Our results suggest that omeprazole retards the differentiation of chief cells in fundic mucosa probably through hypergastrinemia in adult rat.

Original languageEnglish
Pages (from-to)400-408
Number of pages9
JournalBiochemical and Biophysical Research Communications
Volume210
Issue number2
DOIs
Publication statusPublished - 1995 May 16
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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    Kakei, N., Ichinose, M., Tatematsu, M., Shimizu, M., Ishihama, S., Yahagi, N., Matsushima, M., Fukamachi, H., Miki, K., & Kurokawa, K. (1995). Effect of CCK-B Gastrin Receptor Antagonist on Pepsinogen-Producing Cells During Omeprazole Treatment. Biochemical and Biophysical Research Communications, 210(2), 400-408. https://doi.org/10.1006/bbrc.1995.1675