Effect of conditioning regimen on the outcome of bone marrow transplantation from an unrelated donor

Yoshinobu Kanda, Hisashi Sakamaki, Hiroshi Sao, Shinichiro Okamoto, Yoshihisa Kodera, Ryuji Tanosaki, Masaharu Kasai, Akira Hiraoka, Satoshi Takahashi, Shuichi Miyawaki, Takakazu Kawase, Yasuo Morishima, Shunichi Kato

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Little information is available regarding the effect of the conditioning regimen on the outcome of bone marrow transplantation (BMT) from an unrelated donor. Therefore, we retrospectively compared the outcome after a cyclophosphamide/total body irradiation (Cy-TBI) regimen, an intensified Cy-TBI regimen (Cy-TBI+), a busulfan and cyclophosphamide (Bu-Cy) regimen, and a Bu-Cy regimen with total lymphoid irradiation (Bu-Cy-TLI). Clinical data of 1875 adult patients who underwent unmanipulated unrelated BMT for leukemia or myelodysplastic syndrome by using 1 of the 4 regimens between 1993 and 2002 were extracted from the database of the Japan Marrow Donor Program. The effect of the conditioning regimen was adjusted for other independent significant factors by multivariate analyses. The Cy-TBI regimen was significantly better than the Bu-Cy regimen with regard to the incidence of engraftment failure (odds ratio, 2.49; P = .046) and overall survival (relative risk [RR], 1.31; P = .050). The Bu-Cy-TLI regimen decreased relapse (RR, 0.13; P = .039) but increased nonrelapse mortality (RR, 1.89; P = .0061). The Cy-TBI+ regimen resulted in increased nonrelapse mortality (RR, 1.48; P = .0003) and inferior survival (RR, 1.45; P < .0001). The results of this retrospective study suggested that the Cy-TBI regimen was superior to other regimens in unrelated BMT.

Original languageEnglish
Pages (from-to)881-889
Number of pages9
JournalBiology of Blood and Marrow Transplantation
Volume11
Issue number11
DOIs
Publication statusPublished - 2005 Nov

Fingerprint

Unrelated Donors
Bone Marrow Transplantation
Cyclophosphamide
Whole-Body Irradiation
Busulfan
Lymphatic Irradiation
Survival
Mortality
Myelodysplastic Syndromes
Statistical Factor Analysis
Japan
Leukemia
Multivariate Analysis
Retrospective Studies
Bone Marrow
Odds Ratio
Tissue Donors
Databases
Recurrence

Keywords

  • Busulfan
  • Conditioning regimen
  • Cyclophosphamide
  • Total body irradiation
  • Unrelated bone marrow transplantation

ASJC Scopus subject areas

  • Transplantation

Cite this

Effect of conditioning regimen on the outcome of bone marrow transplantation from an unrelated donor. / Kanda, Yoshinobu; Sakamaki, Hisashi; Sao, Hiroshi; Okamoto, Shinichiro; Kodera, Yoshihisa; Tanosaki, Ryuji; Kasai, Masaharu; Hiraoka, Akira; Takahashi, Satoshi; Miyawaki, Shuichi; Kawase, Takakazu; Morishima, Yasuo; Kato, Shunichi.

In: Biology of Blood and Marrow Transplantation, Vol. 11, No. 11, 11.2005, p. 881-889.

Research output: Contribution to journalArticle

Kanda, Y, Sakamaki, H, Sao, H, Okamoto, S, Kodera, Y, Tanosaki, R, Kasai, M, Hiraoka, A, Takahashi, S, Miyawaki, S, Kawase, T, Morishima, Y & Kato, S 2005, 'Effect of conditioning regimen on the outcome of bone marrow transplantation from an unrelated donor', Biology of Blood and Marrow Transplantation, vol. 11, no. 11, pp. 881-889. https://doi.org/10.1016/j.bbmt.2005.07.005
Kanda, Yoshinobu ; Sakamaki, Hisashi ; Sao, Hiroshi ; Okamoto, Shinichiro ; Kodera, Yoshihisa ; Tanosaki, Ryuji ; Kasai, Masaharu ; Hiraoka, Akira ; Takahashi, Satoshi ; Miyawaki, Shuichi ; Kawase, Takakazu ; Morishima, Yasuo ; Kato, Shunichi. / Effect of conditioning regimen on the outcome of bone marrow transplantation from an unrelated donor. In: Biology of Blood and Marrow Transplantation. 2005 ; Vol. 11, No. 11. pp. 881-889.
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AU - Kasai, Masaharu

AU - Hiraoka, Akira

AU - Takahashi, Satoshi

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AU - Kawase, Takakazu

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AU - Kato, Shunichi

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