Effect of conformation of the substrate on enzymatic eecarboxylation of α-Arylmalonic Acid

Kenji Miyamoto, Hiromichi Ohta, Yoshihiro Osamura

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

The configuration and conformation of a compound are critical factors that determine whether it can be accepted by an enzyme is a substrate or not. We have examined enzyme-catalyzed decarboxylation of some α-substituted malonic acids and proposed that the syn-periplanar conformation is required for the substrates to be bound to the active site of the enzyme. Theoretical calculation of potential energy surfaces also supports the conclusion from experimental results.

Original languageEnglish
Pages (from-to)469-475
Number of pages7
JournalBioorganic and Medicinal Chemistry
Volume2
Issue number6
DOIs
Publication statusPublished - 1994 Jun

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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