Effect of cyclic compressive stimuli on mechanical anisotropy of chondrocyte-seeded agarose gel culture

Yuya Okuda, Rei Konishi, Shogo Miyata

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Recently tissue engineering therapy culturing autologous chondrocytes in vitro to create three dimensional tissue for the replacement of damaged tissue has been developed. Although the tissue engineering is a useful approach to reconstruct cartilage in vitro, the mechanical property of the engineered cartilage is not sufficient to replace natural cartilage. Within the natural cartilage, cells and collagen fibers, which are main components of the cartilage, align in response to the direction of cyclic deformations induced by daily walking or other activities. Due to this collagen fiber alignment, the cartilage has mechanical anisotropy. In this study, we focus on the beneficial effect of dynamic compressive loading on tissue regeneration for articular cartilage. The purpose of this study is to create mechanically anisotropic cartilage by compressive stimuli during the culture.

Original languageEnglish
Pages (from-to)1736-1743
Number of pages8
JournalNihon Kikai Gakkai Ronbunshu, C Hen/Transactions of the Japan Society of Mechanical Engineers, Part C
Volume79
Issue number801
DOIs
Publication statusPublished - 2013 Jul 15

Keywords

  • Anisotropy
  • Bone and cartilage
  • Orthopaedic biomechanics
  • Regenerative medicine
  • Tissue engineering

ASJC Scopus subject areas

  • Mechanics of Materials
  • Mechanical Engineering
  • Industrial and Manufacturing Engineering

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