Effect of direct hemoperfusion with a polymyxin B immobilized fiber column in acute exacerbation of interstitial pneumonia and serum indicators

Keisuke Miyamoto, Sadatomo Tasaka, Naoki Hasegawa, Hirofumi Kamata, Hiromi Shinoda, Yoshifumi Kimizuka, Hiroshi Fujiwara, Yoshifumi Kotake, Junzo Takeda, Akitoshi Ishizaka

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Acute exacerbation of interstitial pneumonia (IP-AE) can occasionally occur and has a poor prognosis. Direct hemoperfusion with a polymyxin B immobilized fiber column (PMX-DHP) has been shown to have a beneficial effect on acute respiratory distress syndrome, which has similar pathological features to that of IP-AE. This study was aimed to investigate the effects of PMX-DHP on IP-AE and serum indicators for epithelial damage. Nine patients with a clinical diagnosis of interstitial pneumonia, who developed acute exacerbation, were included in this study. Five patients had been given a diagnosis of idiopathic pulmonary fibrosis (IPF) and 3 cases were diagnosed as collagen vascular disease-associated interstitial pneumonia (CVD-IP). On days 30 and 60, 6 and 4 patients were surviving, respectively. On day 60, all 3 patients with CVD-IP were alive, while 4 of 5 patients with IPF had died. In 4 patients who survived for 60 days or longer, serum levels of LDH, CRP, and SP-D were significantly decreased after PMX-DHP, whereas KL-6 level was unchanged. In 5 patients, who died by day 60, no significant changes in the serum markers were observed. These data suggest that serum levels of LDH, CRP, and SP-D might be predictive of successful PMX-DHP treatment in cases of IP-AE.

Original languageEnglish
Pages (from-to)978-984
Number of pages7
JournalNihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society
Issue number11
Publication statusPublished - 2009 Nov


ASJC Scopus subject areas

  • Medicine(all)

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