Effect of distal subtotal gastrectomy with preservation of the celiac branch of the vagus nerve to gastrointestinal function: An experimental study in conscious dogs

Hiroyuki Ando, Erito Mochiki, Tetsuro Ohno, Norimichi Kogure, Naritaka Tanaka, Yuichi Tabe, Hitoshi Kimura, Yoichi Kamiyama, Ryuusuke Aihara, Toshihiro Nakabayashi, Takayuki Asao, Tohru Aomori, Yukiyoshi Fujita, Hiroyuki Kuwano

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20 Citations (Scopus)

Abstract

OBJECTIVE: To evaluate the effects of distal subtotal gastrectomy with preservation of the celiac branch of the vagus nerve on gastrointestinal function. SUMMARY BACKGROUND DATA: The operative procedure of distal subtotal gastrectomy with preservation of the celiac branch of the vagus nerve is now in the spotlight in Japan with the goal of finding a function-preserving surgical technique. However, there has been no analysis of the effect of this type of surgery on gastrointestinal function. In this article, we describe the results of a fundamental experiment on distal subtotal gastrectomy with preservation of the celiac branch of the vagus nerve. METHODS: Twenty conscious dogs were divided into 2 groups, each subdivided into 2 groups of 5: a normal intact dog group (NG) divided into 2 groups, with preservation (PNG) and resection (RNG; these dogs were truncally vagotomized including transaction of the celiac branch) of the celiac branch, and a gastrectomy dog group (GG) divided into 2 groups, with preservation (PGG) and resection (RGG) of the celiac branch. The motility of the dogs was recorded using strain gauge force transducers. The effects of the preservation of the celiac branch of the vagus nerve on gastrointestinal motility, gastric emptying, and pancreatic insulin release were evaluated. RESULTS: The motility index of gastrointestinal motility with preservation of the celiac branch was higher than the motility index with resection of the celiac branch in fasted and fed of NG and GG. In gastric emptying, significant differences were found between the PNG and RNG but not between the PGG and RGG. In the fasted state for 80 minutes of the PNG and PGG, the serum insulin concentration reached a peak during the early phase III at 20 minutes in the gastric body and the antrum. CONCLUSIONS: This study has shown that it is effective to preserve the celiac branch of the vagus nerve for gastroduodenal motility, gastric emptying, and pancreatic insulin release after a gastrectomy.

Original languageEnglish
Pages (from-to)976-986
Number of pages11
JournalAnnals of surgery
Volume247
Issue number6
DOIs
Publication statusPublished - 2008 Jun 1
Externally publishedYes

ASJC Scopus subject areas

  • Surgery

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    Ando, H., Mochiki, E., Ohno, T., Kogure, N., Tanaka, N., Tabe, Y., Kimura, H., Kamiyama, Y., Aihara, R., Nakabayashi, T., Asao, T., Aomori, T., Fujita, Y., & Kuwano, H. (2008). Effect of distal subtotal gastrectomy with preservation of the celiac branch of the vagus nerve to gastrointestinal function: An experimental study in conscious dogs. Annals of surgery, 247(6), 976-986. https://doi.org/10.1097/SLA.0b013e31816ffb1c