Effect of distal subtotal gastrectomy with preservation of the celiac branch of the vagus nerve to gastrointestinal function: An experimental study in conscious dogs

Hiroyuki Ando, Erito Mochiki, Tetsuro Ohno, Norimichi Kogure, Naritaka Tanaka, Yuichi Tabe, Hitoshi Kimura, Yoichi Kamiyama, Ryuusuke Aihara, Toshihiro Nakabayashi, Takayuki Asao, Tohru Aomori, Yukiyoshi Fujita, Hiroyuki Kuwano

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

OBJECTIVE: To evaluate the effects of distal subtotal gastrectomy with preservation of the celiac branch of the vagus nerve on gastrointestinal function. SUMMARY BACKGROUND DATA: The operative procedure of distal subtotal gastrectomy with preservation of the celiac branch of the vagus nerve is now in the spotlight in Japan with the goal of finding a function-preserving surgical technique. However, there has been no analysis of the effect of this type of surgery on gastrointestinal function. In this article, we describe the results of a fundamental experiment on distal subtotal gastrectomy with preservation of the celiac branch of the vagus nerve. METHODS: Twenty conscious dogs were divided into 2 groups, each subdivided into 2 groups of 5: a normal intact dog group (NG) divided into 2 groups, with preservation (PNG) and resection (RNG; these dogs were truncally vagotomized including transaction of the celiac branch) of the celiac branch, and a gastrectomy dog group (GG) divided into 2 groups, with preservation (PGG) and resection (RGG) of the celiac branch. The motility of the dogs was recorded using strain gauge force transducers. The effects of the preservation of the celiac branch of the vagus nerve on gastrointestinal motility, gastric emptying, and pancreatic insulin release were evaluated. RESULTS: The motility index of gastrointestinal motility with preservation of the celiac branch was higher than the motility index with resection of the celiac branch in fasted and fed of NG and GG. In gastric emptying, significant differences were found between the PNG and RNG but not between the PGG and RGG. In the fasted state for 80 minutes of the PNG and PGG, the serum insulin concentration reached a peak during the early phase III at 20 minutes in the gastric body and the antrum. CONCLUSIONS: This study has shown that it is effective to preserve the celiac branch of the vagus nerve for gastroduodenal motility, gastric emptying, and pancreatic insulin release after a gastrectomy.

Original languageEnglish
Pages (from-to)976-986
Number of pages11
JournalAnnals of Surgery
Volume247
Issue number6
DOIs
Publication statusPublished - 2008 Jun
Externally publishedYes

Fingerprint

Vagus Nerve
Gastrectomy
Abdomen
Dogs
Prostaglandins G
Gastric Emptying
Gastrointestinal Motility
Insulin
Pyloric Antrum
Operative Surgical Procedures
Transducers
Japan

ASJC Scopus subject areas

  • Surgery

Cite this

Effect of distal subtotal gastrectomy with preservation of the celiac branch of the vagus nerve to gastrointestinal function : An experimental study in conscious dogs. / Ando, Hiroyuki; Mochiki, Erito; Ohno, Tetsuro; Kogure, Norimichi; Tanaka, Naritaka; Tabe, Yuichi; Kimura, Hitoshi; Kamiyama, Yoichi; Aihara, Ryuusuke; Nakabayashi, Toshihiro; Asao, Takayuki; Aomori, Tohru; Fujita, Yukiyoshi; Kuwano, Hiroyuki.

In: Annals of Surgery, Vol. 247, No. 6, 06.2008, p. 976-986.

Research output: Contribution to journalArticle

Ando, H, Mochiki, E, Ohno, T, Kogure, N, Tanaka, N, Tabe, Y, Kimura, H, Kamiyama, Y, Aihara, R, Nakabayashi, T, Asao, T, Aomori, T, Fujita, Y & Kuwano, H 2008, 'Effect of distal subtotal gastrectomy with preservation of the celiac branch of the vagus nerve to gastrointestinal function: An experimental study in conscious dogs', Annals of Surgery, vol. 247, no. 6, pp. 976-986. https://doi.org/10.1097/SLA.0b013e31816ffb1c
Ando, Hiroyuki ; Mochiki, Erito ; Ohno, Tetsuro ; Kogure, Norimichi ; Tanaka, Naritaka ; Tabe, Yuichi ; Kimura, Hitoshi ; Kamiyama, Yoichi ; Aihara, Ryuusuke ; Nakabayashi, Toshihiro ; Asao, Takayuki ; Aomori, Tohru ; Fujita, Yukiyoshi ; Kuwano, Hiroyuki. / Effect of distal subtotal gastrectomy with preservation of the celiac branch of the vagus nerve to gastrointestinal function : An experimental study in conscious dogs. In: Annals of Surgery. 2008 ; Vol. 247, No. 6. pp. 976-986.
@article{e0adb5ebb25d46a097a8c2b65c4a4e8c,
title = "Effect of distal subtotal gastrectomy with preservation of the celiac branch of the vagus nerve to gastrointestinal function: An experimental study in conscious dogs",
abstract = "OBJECTIVE: To evaluate the effects of distal subtotal gastrectomy with preservation of the celiac branch of the vagus nerve on gastrointestinal function. SUMMARY BACKGROUND DATA: The operative procedure of distal subtotal gastrectomy with preservation of the celiac branch of the vagus nerve is now in the spotlight in Japan with the goal of finding a function-preserving surgical technique. However, there has been no analysis of the effect of this type of surgery on gastrointestinal function. In this article, we describe the results of a fundamental experiment on distal subtotal gastrectomy with preservation of the celiac branch of the vagus nerve. METHODS: Twenty conscious dogs were divided into 2 groups, each subdivided into 2 groups of 5: a normal intact dog group (NG) divided into 2 groups, with preservation (PNG) and resection (RNG; these dogs were truncally vagotomized including transaction of the celiac branch) of the celiac branch, and a gastrectomy dog group (GG) divided into 2 groups, with preservation (PGG) and resection (RGG) of the celiac branch. The motility of the dogs was recorded using strain gauge force transducers. The effects of the preservation of the celiac branch of the vagus nerve on gastrointestinal motility, gastric emptying, and pancreatic insulin release were evaluated. RESULTS: The motility index of gastrointestinal motility with preservation of the celiac branch was higher than the motility index with resection of the celiac branch in fasted and fed of NG and GG. In gastric emptying, significant differences were found between the PNG and RNG but not between the PGG and RGG. In the fasted state for 80 minutes of the PNG and PGG, the serum insulin concentration reached a peak during the early phase III at 20 minutes in the gastric body and the antrum. CONCLUSIONS: This study has shown that it is effective to preserve the celiac branch of the vagus nerve for gastroduodenal motility, gastric emptying, and pancreatic insulin release after a gastrectomy.",
author = "Hiroyuki Ando and Erito Mochiki and Tetsuro Ohno and Norimichi Kogure and Naritaka Tanaka and Yuichi Tabe and Hitoshi Kimura and Yoichi Kamiyama and Ryuusuke Aihara and Toshihiro Nakabayashi and Takayuki Asao and Tohru Aomori and Yukiyoshi Fujita and Hiroyuki Kuwano",
year = "2008",
month = "6",
doi = "10.1097/SLA.0b013e31816ffb1c",
language = "English",
volume = "247",
pages = "976--986",
journal = "Annals of Surgery",
issn = "0003-4932",
publisher = "Lippincott Williams and Wilkins",
number = "6",

}

TY - JOUR

T1 - Effect of distal subtotal gastrectomy with preservation of the celiac branch of the vagus nerve to gastrointestinal function

T2 - An experimental study in conscious dogs

AU - Ando, Hiroyuki

AU - Mochiki, Erito

AU - Ohno, Tetsuro

AU - Kogure, Norimichi

AU - Tanaka, Naritaka

AU - Tabe, Yuichi

AU - Kimura, Hitoshi

AU - Kamiyama, Yoichi

AU - Aihara, Ryuusuke

AU - Nakabayashi, Toshihiro

AU - Asao, Takayuki

AU - Aomori, Tohru

AU - Fujita, Yukiyoshi

AU - Kuwano, Hiroyuki

PY - 2008/6

Y1 - 2008/6

N2 - OBJECTIVE: To evaluate the effects of distal subtotal gastrectomy with preservation of the celiac branch of the vagus nerve on gastrointestinal function. SUMMARY BACKGROUND DATA: The operative procedure of distal subtotal gastrectomy with preservation of the celiac branch of the vagus nerve is now in the spotlight in Japan with the goal of finding a function-preserving surgical technique. However, there has been no analysis of the effect of this type of surgery on gastrointestinal function. In this article, we describe the results of a fundamental experiment on distal subtotal gastrectomy with preservation of the celiac branch of the vagus nerve. METHODS: Twenty conscious dogs were divided into 2 groups, each subdivided into 2 groups of 5: a normal intact dog group (NG) divided into 2 groups, with preservation (PNG) and resection (RNG; these dogs were truncally vagotomized including transaction of the celiac branch) of the celiac branch, and a gastrectomy dog group (GG) divided into 2 groups, with preservation (PGG) and resection (RGG) of the celiac branch. The motility of the dogs was recorded using strain gauge force transducers. The effects of the preservation of the celiac branch of the vagus nerve on gastrointestinal motility, gastric emptying, and pancreatic insulin release were evaluated. RESULTS: The motility index of gastrointestinal motility with preservation of the celiac branch was higher than the motility index with resection of the celiac branch in fasted and fed of NG and GG. In gastric emptying, significant differences were found between the PNG and RNG but not between the PGG and RGG. In the fasted state for 80 minutes of the PNG and PGG, the serum insulin concentration reached a peak during the early phase III at 20 minutes in the gastric body and the antrum. CONCLUSIONS: This study has shown that it is effective to preserve the celiac branch of the vagus nerve for gastroduodenal motility, gastric emptying, and pancreatic insulin release after a gastrectomy.

AB - OBJECTIVE: To evaluate the effects of distal subtotal gastrectomy with preservation of the celiac branch of the vagus nerve on gastrointestinal function. SUMMARY BACKGROUND DATA: The operative procedure of distal subtotal gastrectomy with preservation of the celiac branch of the vagus nerve is now in the spotlight in Japan with the goal of finding a function-preserving surgical technique. However, there has been no analysis of the effect of this type of surgery on gastrointestinal function. In this article, we describe the results of a fundamental experiment on distal subtotal gastrectomy with preservation of the celiac branch of the vagus nerve. METHODS: Twenty conscious dogs were divided into 2 groups, each subdivided into 2 groups of 5: a normal intact dog group (NG) divided into 2 groups, with preservation (PNG) and resection (RNG; these dogs were truncally vagotomized including transaction of the celiac branch) of the celiac branch, and a gastrectomy dog group (GG) divided into 2 groups, with preservation (PGG) and resection (RGG) of the celiac branch. The motility of the dogs was recorded using strain gauge force transducers. The effects of the preservation of the celiac branch of the vagus nerve on gastrointestinal motility, gastric emptying, and pancreatic insulin release were evaluated. RESULTS: The motility index of gastrointestinal motility with preservation of the celiac branch was higher than the motility index with resection of the celiac branch in fasted and fed of NG and GG. In gastric emptying, significant differences were found between the PNG and RNG but not between the PGG and RGG. In the fasted state for 80 minutes of the PNG and PGG, the serum insulin concentration reached a peak during the early phase III at 20 minutes in the gastric body and the antrum. CONCLUSIONS: This study has shown that it is effective to preserve the celiac branch of the vagus nerve for gastroduodenal motility, gastric emptying, and pancreatic insulin release after a gastrectomy.

UR - http://www.scopus.com/inward/record.url?scp=44449176200&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=44449176200&partnerID=8YFLogxK

U2 - 10.1097/SLA.0b013e31816ffb1c

DO - 10.1097/SLA.0b013e31816ffb1c

M3 - Article

C2 - 18520225

AN - SCOPUS:44449176200

VL - 247

SP - 976

EP - 986

JO - Annals of Surgery

JF - Annals of Surgery

SN - 0003-4932

IS - 6

ER -