Effect of estradiol and ethynylestradiol on microtubule distribution in Chinese hamster V79 cells

Y. Sato, Y. Sakakibara, T. Oda, Eriko Yokota, K. Ichinoseki

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39 Citations (Scopus)

Abstract

The effects of estradiol (E2) and ethynylestradiol (EE2) on the chromosome number and cellular microtubule architecture of Chinese hamster V79 cells were studied using fluorescent anti-tubulin antibody. Treatment with 20 μM E2 for 48 h induced only a small amount of tetraploid cells, but the normal microtubule network was disrupted completely by only 3 h of treatment. This data reveals that E2 has higher microtubule-disruptive activity than diethylstilbestrol in V79 cells.

Original languageEnglish
Pages (from-to)182-184
Number of pages3
JournalChemical and Pharmaceutical Bulletin
Volume40
Issue number1
Publication statusPublished - 1992

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ASJC Scopus subject areas

  • Chemistry(all)
  • Organic Chemistry
  • Drug Discovery
  • Pharmacology

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