The effects of estradiol (E2) and ethynylestradiol (EE2) on the chromosome number and cellular microtubule architecture of Chinese hamster V79 cells were studied using fluorescent anti-tubulin antibody. Treatment with 20 μM E2 for 48 h induced only a small amount of tetraploid cells, but the normal microtubule network was disrupted completely by only 3 h of treatment. This data reveals that E2 has higher microtubule-disruptive activity than diethylstilbestrol in V79 cells.
|Number of pages||3|
|Journal||Chemical and Pharmaceutical Bulletin|
|Publication status||Published - 1992|
ASJC Scopus subject areas
- Organic Chemistry
- Drug Discovery