Effect of Estradiol and Ethynylestradiol on Microtubule Distribution in Chinese Hamster V79 Cells

Yoshihiro Sato, Yumiko Sakakibara, Taiko Oda, Eriko Aizu-Yokota, Ken Ichinoseki

Research output: Contribution to journalArticlepeer-review

39 Citations (Scopus)

Abstract

The effects of estradiol (E2) and ethynylestradiol (EE2) on the chromosome number and cellular microtubule architecture of Chinese hamster V79 cells were studied using fluorescent anti-tubulin antibody. Treatment with 20 pM E2 for 48 h induced only a small amount of tetraploid cells, but the normal microtubule network was disrupted completely by only 3h of treatment. This data reveals that E2 has higher microtubule-disruptive activity than diethylstilbestrol in V79 cells.

Original languageEnglish
Pages (from-to)182-184
Number of pages3
JournalChemical and Pharmaceutical Bulletin
Volume40
Issue number1
DOIs
Publication statusPublished - 1992

Keywords

  • aneuploidy
  • chromosome aberration
  • estradiol
  • ethynylestradiol
  • immunofluorescence
  • microtubule distribution

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

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