Effect of estradiol and ethynylestradiol on microtubule distribution in Chinese hamster V79 cells

Y. Sato, Y. Sakakibara, T. Oda, Eriko Yokota, K. Ichinoseki

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

The effects of estradiol (E2) and ethynylestradiol (EE2) on the chromosome number and cellular microtubule architecture of Chinese hamster V79 cells were studied using fluorescent anti-tubulin antibody. Treatment with 20 μM E2 for 48 h induced only a small amount of tetraploid cells, but the normal microtubule network was disrupted completely by only 3 h of treatment. This data reveals that E2 has higher microtubule-disruptive activity than diethylstilbestrol in V79 cells.

Original languageEnglish
Pages (from-to)182-184
Number of pages3
JournalChemical and Pharmaceutical Bulletin
Volume40
Issue number1
Publication statusPublished - 1992

Fingerprint

Diethylstilbestrol
Tubulin
Chromosomes
Cricetulus
Microtubules
Estradiol
Antibodies
Tetraploidy
Anti-Idiotypic Antibodies

ASJC Scopus subject areas

  • Chemistry(all)
  • Organic Chemistry
  • Drug Discovery
  • Pharmacology

Cite this

Effect of estradiol and ethynylestradiol on microtubule distribution in Chinese hamster V79 cells. / Sato, Y.; Sakakibara, Y.; Oda, T.; Yokota, Eriko; Ichinoseki, K.

In: Chemical and Pharmaceutical Bulletin, Vol. 40, No. 1, 1992, p. 182-184.

Research output: Contribution to journalArticle

@article{c52f74eaaae645818a0ce8e2a96ed569,
title = "Effect of estradiol and ethynylestradiol on microtubule distribution in Chinese hamster V79 cells",
abstract = "The effects of estradiol (E2) and ethynylestradiol (EE2) on the chromosome number and cellular microtubule architecture of Chinese hamster V79 cells were studied using fluorescent anti-tubulin antibody. Treatment with 20 μM E2 for 48 h induced only a small amount of tetraploid cells, but the normal microtubule network was disrupted completely by only 3 h of treatment. This data reveals that E2 has higher microtubule-disruptive activity than diethylstilbestrol in V79 cells.",
author = "Y. Sato and Y. Sakakibara and T. Oda and Eriko Yokota and K. Ichinoseki",
year = "1992",
language = "English",
volume = "40",
pages = "182--184",
journal = "Chemical and Pharmaceutical Bulletin",
issn = "0009-2363",
publisher = "Pharmaceutical Society of Japan",
number = "1",

}

TY - JOUR

T1 - Effect of estradiol and ethynylestradiol on microtubule distribution in Chinese hamster V79 cells

AU - Sato, Y.

AU - Sakakibara, Y.

AU - Oda, T.

AU - Yokota, Eriko

AU - Ichinoseki, K.

PY - 1992

Y1 - 1992

N2 - The effects of estradiol (E2) and ethynylestradiol (EE2) on the chromosome number and cellular microtubule architecture of Chinese hamster V79 cells were studied using fluorescent anti-tubulin antibody. Treatment with 20 μM E2 for 48 h induced only a small amount of tetraploid cells, but the normal microtubule network was disrupted completely by only 3 h of treatment. This data reveals that E2 has higher microtubule-disruptive activity than diethylstilbestrol in V79 cells.

AB - The effects of estradiol (E2) and ethynylestradiol (EE2) on the chromosome number and cellular microtubule architecture of Chinese hamster V79 cells were studied using fluorescent anti-tubulin antibody. Treatment with 20 μM E2 for 48 h induced only a small amount of tetraploid cells, but the normal microtubule network was disrupted completely by only 3 h of treatment. This data reveals that E2 has higher microtubule-disruptive activity than diethylstilbestrol in V79 cells.

UR - http://www.scopus.com/inward/record.url?scp=0026531029&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026531029&partnerID=8YFLogxK

M3 - Article

C2 - 1576671

AN - SCOPUS:0026531029

VL - 40

SP - 182

EP - 184

JO - Chemical and Pharmaceutical Bulletin

JF - Chemical and Pharmaceutical Bulletin

SN - 0009-2363

IS - 1

ER -