Effect of eyelid hygiene detergent on obstructive meibomian gland dysfunction

Hirotaka Tanabe, Minako Kaido, Motoko Kawashima, Reiko Ishida, Masahiko Ayaki, Kazuo Tsubota

Research output: Contribution to journalArticle

Abstract

Purpose: To investigate the efficacy of eyelid margin cleansing with lid hygiene detergent in patients with obstructive meibomian gland dysfunction (MGD). Methods: As a pilot study, we investigated the safety and efficacy of lid hygiene using tap water and/or lid hygiene shampoo in fourteen eyes of 7 normal subjects. All subjects were instructed to cleanse the eyelid margin with tap water and/or lid hygiene shampoo. As a main prospective clinical study, thirty-four eyes of 34 patients with obstructive MGD were enrolled. All subjects were instructed to cleanse the eyelid margin with lid hygiene shampoo at least once daily for 1 month. Ocular surface conditions were observed before and 1 month after study initiation. Results: A significant exacerbating change (p < 0.05) was not detected after either method in the pilot study. In the main study, significant improvements were observed in tear break-up time (TBUT), lid margin lissamine green staining scores, vascular dilatation, and meibum status (p < 0.05). No significant improvements in corneal or conjunctival fluorescein staining scores, the mucocutaneous junction, lid margin deformation, or plugging were observed (p ≥ 0.05). Subjective improvements were observed in 27 subjects. Meibography revealed that 28 subjects had normal meibomian glands, and 6 subjects had meibomian gland atrophy. Significant improvements were observed in TBUT, vascular dilatation, and meibum status only in the group with normal meibomian glands (p < 0.05), but subjective symptoms and lid margin lissamine green staining scores improved in both groups (p < 0.05). No subjects experienced any problems throughout the study. Conclusion: Daily routine use of lid hygiene detergent can alleviate the symptoms of MGD regardless of meibomian gland atrophy.

Original languageEnglish
Pages (from-to)67-78
Number of pages12
JournalJournal of Oleo Science
Volume68
Issue number1
DOIs
Publication statusPublished - 2019 Jan 1

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Detergents
Water
Fluorescein

Keywords

  • Dry eye
  • Eye shampoo
  • Lid hygiene
  • Lid hygiene detergent
  • Meibomian gland dysfunction

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

Cite this

Effect of eyelid hygiene detergent on obstructive meibomian gland dysfunction. / Tanabe, Hirotaka; Kaido, Minako; Kawashima, Motoko; Ishida, Reiko; Ayaki, Masahiko; Tsubota, Kazuo.

In: Journal of Oleo Science, Vol. 68, No. 1, 01.01.2019, p. 67-78.

Research output: Contribution to journalArticle

Tanabe, Hirotaka ; Kaido, Minako ; Kawashima, Motoko ; Ishida, Reiko ; Ayaki, Masahiko ; Tsubota, Kazuo. / Effect of eyelid hygiene detergent on obstructive meibomian gland dysfunction. In: Journal of Oleo Science. 2019 ; Vol. 68, No. 1. pp. 67-78.
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abstract = "Purpose: To investigate the efficacy of eyelid margin cleansing with lid hygiene detergent in patients with obstructive meibomian gland dysfunction (MGD). Methods: As a pilot study, we investigated the safety and efficacy of lid hygiene using tap water and/or lid hygiene shampoo in fourteen eyes of 7 normal subjects. All subjects were instructed to cleanse the eyelid margin with tap water and/or lid hygiene shampoo. As a main prospective clinical study, thirty-four eyes of 34 patients with obstructive MGD were enrolled. All subjects were instructed to cleanse the eyelid margin with lid hygiene shampoo at least once daily for 1 month. Ocular surface conditions were observed before and 1 month after study initiation. Results: A significant exacerbating change (p < 0.05) was not detected after either method in the pilot study. In the main study, significant improvements were observed in tear break-up time (TBUT), lid margin lissamine green staining scores, vascular dilatation, and meibum status (p < 0.05). No significant improvements in corneal or conjunctival fluorescein staining scores, the mucocutaneous junction, lid margin deformation, or plugging were observed (p ≥ 0.05). Subjective improvements were observed in 27 subjects. Meibography revealed that 28 subjects had normal meibomian glands, and 6 subjects had meibomian gland atrophy. Significant improvements were observed in TBUT, vascular dilatation, and meibum status only in the group with normal meibomian glands (p < 0.05), but subjective symptoms and lid margin lissamine green staining scores improved in both groups (p < 0.05). No subjects experienced any problems throughout the study. Conclusion: Daily routine use of lid hygiene detergent can alleviate the symptoms of MGD regardless of meibomian gland atrophy.",
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