Effect of fluoroquinolones on plasma glucose levels in fasted and glucose-loaded mice

Seiji Hori, Junko Kizu, Masahiro Kawamura

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

In fasted mice, plasma glucose levels were reduced by intraperitoneal administration of enoxacin, lomefloxacin, or gatifloxacin (50 mg/kg). A lower dose of these fluoroquinolones (5 mg/kg) also reduced the plasma glucose (PG) levels in glucose-loaded mice. Ciprofloxacin and levofloxacin did not reduce these levels in either fasted or glucose-loaded mice. These results suggest that each fluoroquinolone has an individual hypoglycemic action, and fluoroquinolone administration after meals might reduce PG levels at lower doses.

Original languageEnglish
Pages (from-to)109-111
Number of pages3
JournalJournal of Infection and Chemotherapy
Volume12
Issue number2
DOIs
Publication statusPublished - 2006 Apr

Fingerprint

Fluoroquinolones
Glucose
Enoxacin
Levofloxacin
Ciprofloxacin
Hypoglycemic Agents
Meals

Keywords

  • Enoxacin
  • Gatifloxacin
  • Hypoglycemia
  • Lomefloxacin
  • Mice

ASJC Scopus subject areas

  • Microbiology (medical)

Cite this

Effect of fluoroquinolones on plasma glucose levels in fasted and glucose-loaded mice. / Hori, Seiji; Kizu, Junko; Kawamura, Masahiro.

In: Journal of Infection and Chemotherapy, Vol. 12, No. 2, 04.2006, p. 109-111.

Research output: Contribution to journalArticle

Hori, Seiji ; Kizu, Junko ; Kawamura, Masahiro. / Effect of fluoroquinolones on plasma glucose levels in fasted and glucose-loaded mice. In: Journal of Infection and Chemotherapy. 2006 ; Vol. 12, No. 2. pp. 109-111.
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