Effect of fluoroquinolones on plasma glucose levels in fasted and glucose-loaded mice

Seiji Hori, Junko Kizu, Masahiro Kawamura

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In fasted mice, plasma glucose levels were reduced by intraperitoneal administration of enoxacin, lomefloxacin, or gatifloxacin (50 mg/kg). A lower dose of these fluoroquinolones (5 mg/kg) also reduced the plasma glucose (PG) levels in glucose-loaded mice. Ciprofloxacin and levofloxacin did not reduce these levels in either fasted or glucose-loaded mice. These results suggest that each fluoroquinolone has an individual hypoglycemic action, and fluoroquinolone administration after meals might reduce PG levels at lower doses.

Original languageEnglish
Pages (from-to)109-111
Number of pages3
JournalJournal of Infection and Chemotherapy
Issue number2
Publication statusPublished - 2006 Apr



  • Enoxacin
  • Gatifloxacin
  • Hypoglycemia
  • Lomefloxacin
  • Mice

ASJC Scopus subject areas

  • Microbiology (medical)
  • Pharmacology (medical)
  • Infectious Diseases

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