Effect of hepatic arterial infusion chemotherapy of 5-fluorouracil and cisplatin for advanced hepatocellular carcinoma in the nationwide survey of primary liver cancer in Japan

K. Nouso, K. Miyahara, D. Uchida, K. Kuwaki, N. Izumi, M. Omata, T. Ichida, M. Kudo, Y. Ku, N. Kokudo, M. Sakamoto, O. Nakashima, T. Takayama, O. Matsui, Y. Matsuyama, K. Yamamoto

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Abstract

Background:The efficacy of hepatic arterial infusion chemotherapy for the treatment of advanced hepatocellular carcinoma (HCC) remains unclear.Methods:The outcome of 476 patients with HCC who underwent hepatic arterial infusion chemotherapy with 5-fluorouracil and cisplatin (HAIC) were compared with 1466 patients who did not receive active therapy.Results:A survival benefit of the therapy after adjusting for known risk factors was observed (hazard ratio, 0.48; 95% CI, 0.41-0.56; P<0.0001). In propensity score-matched analysis (n=682), median survival time was longer for patients who underwent chemotherapy (14.0 months) than for patients who did not receive active treatment (5.2 months, P<0.0001).Conclusion:For advanced HCC, HAIC is considered to be an effective treatment.

Original languageEnglish
Pages (from-to)1904-1907
Number of pages4
JournalBritish Journal of Cancer
Volume109
Issue number7
DOIs
Publication statusPublished - 2013 Oct 1

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Keywords

  • 5-fluorouracil
  • chemotherapy
  • cisplatin
  • hepatocellular carcinoma
  • liver neoplasm
  • propensity score

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Nouso, K., Miyahara, K., Uchida, D., Kuwaki, K., Izumi, N., Omata, M., Ichida, T., Kudo, M., Ku, Y., Kokudo, N., Sakamoto, M., Nakashima, O., Takayama, T., Matsui, O., Matsuyama, Y., & Yamamoto, K. (2013). Effect of hepatic arterial infusion chemotherapy of 5-fluorouracil and cisplatin for advanced hepatocellular carcinoma in the nationwide survey of primary liver cancer in Japan. British Journal of Cancer, 109(7), 1904-1907. https://doi.org/10.1038/bjc.2013.542