Effect of Intermittent Cyclical Etidronate Therapy on Corticosteroid Induced Osteoporosis in Japanese Patients with Connective Tissue Disease: 3 Year Followup

Shinji Sato, Yasuo Ohosone, Akira Suwa, Hidekata Yasuoka, Takaki Nojima, Takao Fujii, Masataka Kuwana, Kunio Nakamura, Tsuneyo Mimori, Michito Hirakata

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Objective. A 3 year prospective randomized study was conducted to clarify the efficacy of intermittent cyclical etidronate therapy on corticosteroid induced osteoporosis. Methods. A group of 102 Japanese patients were enrolled, each taking > 7.5 mg of prednisolone daily for at least 90 days. Patients were randomly divided into 2 treatment groups: Group E (etidronate) took 200 mg etidronate disodium per day for 2 weeks with 3.0 g calcium lactate and 0.75 μg alphacalcidol daily; Group C (control) took 3.0 g calcium lactate and 0. 75 μg alphacalcidol daily. Outcome measurements included changes from baseline in bone mineral density (BMD) of the lumbar spine and the rate of new vertebral fractures at 48 and 144 weeks. Results. The mean (± SD) lumbar spine BMD increased 3.7 ± 5.6% (p < 0.01) and 1.5 ± 4.1% (NS) from baseline at 48 weeks and 4.8 ± 6.9% (p < 0.005) and 0.4 ± 5.0% (NS) from baseline at 144 weeks in Group E and Group C, respectively. The improvement of BMD in Group E was significantly greater than in Group C at 144 weeks (p < 0.01). In 3 subgroups, men and premenopausal and postmenopausal women, the postmenopausal women showed the greatest improvement. Mean percentage change in this subgroup was 10.1 ± 8.0% and 1.35 ± 6. 4% in Group E and Group C, respectively. We noted that 2 patients in Group C had new vertebral fractures, whereas no fractures were observed in Group E. Conclusion. These results indicate that intermittent cyclical etidronate therapy is effective for the prevention and treatment of corticosteroid induced osteoporosis in patients with connective tissue diseases.

Original languageEnglish
Pages (from-to)2673-2679
Number of pages7
JournalJournal of Rheumatology
Volume30
Issue number12
Publication statusPublished - 2003 Dec

Fingerprint

Etidronic Acid
Connective Tissue Diseases
Osteoporosis
Adrenal Cortex Hormones
Bone Density
Spine
Therapeutics
Prednisolone
Prospective Studies
Control Groups
calcium lactate
alfacalcidol

Keywords

  • Bisphosphonate
  • Bone mineral density
  • Connective tissue diseases
  • Corticosteroid induced osteoporosis

ASJC Scopus subject areas

  • Rheumatology
  • Immunology

Cite this

Effect of Intermittent Cyclical Etidronate Therapy on Corticosteroid Induced Osteoporosis in Japanese Patients with Connective Tissue Disease : 3 Year Followup. / Sato, Shinji; Ohosone, Yasuo; Suwa, Akira; Yasuoka, Hidekata; Nojima, Takaki; Fujii, Takao; Kuwana, Masataka; Nakamura, Kunio; Mimori, Tsuneyo; Hirakata, Michito.

In: Journal of Rheumatology, Vol. 30, No. 12, 12.2003, p. 2673-2679.

Research output: Contribution to journalArticle

Sato, S, Ohosone, Y, Suwa, A, Yasuoka, H, Nojima, T, Fujii, T, Kuwana, M, Nakamura, K, Mimori, T & Hirakata, M 2003, 'Effect of Intermittent Cyclical Etidronate Therapy on Corticosteroid Induced Osteoporosis in Japanese Patients with Connective Tissue Disease: 3 Year Followup', Journal of Rheumatology, vol. 30, no. 12, pp. 2673-2679.
Sato, Shinji ; Ohosone, Yasuo ; Suwa, Akira ; Yasuoka, Hidekata ; Nojima, Takaki ; Fujii, Takao ; Kuwana, Masataka ; Nakamura, Kunio ; Mimori, Tsuneyo ; Hirakata, Michito. / Effect of Intermittent Cyclical Etidronate Therapy on Corticosteroid Induced Osteoporosis in Japanese Patients with Connective Tissue Disease : 3 Year Followup. In: Journal of Rheumatology. 2003 ; Vol. 30, No. 12. pp. 2673-2679.
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abstract = "Objective. A 3 year prospective randomized study was conducted to clarify the efficacy of intermittent cyclical etidronate therapy on corticosteroid induced osteoporosis. Methods. A group of 102 Japanese patients were enrolled, each taking > 7.5 mg of prednisolone daily for at least 90 days. Patients were randomly divided into 2 treatment groups: Group E (etidronate) took 200 mg etidronate disodium per day for 2 weeks with 3.0 g calcium lactate and 0.75 μg alphacalcidol daily; Group C (control) took 3.0 g calcium lactate and 0. 75 μg alphacalcidol daily. Outcome measurements included changes from baseline in bone mineral density (BMD) of the lumbar spine and the rate of new vertebral fractures at 48 and 144 weeks. Results. The mean (± SD) lumbar spine BMD increased 3.7 ± 5.6{\%} (p < 0.01) and 1.5 ± 4.1{\%} (NS) from baseline at 48 weeks and 4.8 ± 6.9{\%} (p < 0.005) and 0.4 ± 5.0{\%} (NS) from baseline at 144 weeks in Group E and Group C, respectively. The improvement of BMD in Group E was significantly greater than in Group C at 144 weeks (p < 0.01). In 3 subgroups, men and premenopausal and postmenopausal women, the postmenopausal women showed the greatest improvement. Mean percentage change in this subgroup was 10.1 ± 8.0{\%} and 1.35 ± 6. 4{\%} in Group E and Group C, respectively. We noted that 2 patients in Group C had new vertebral fractures, whereas no fractures were observed in Group E. Conclusion. These results indicate that intermittent cyclical etidronate therapy is effective for the prevention and treatment of corticosteroid induced osteoporosis in patients with connective tissue diseases.",
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T1 - Effect of Intermittent Cyclical Etidronate Therapy on Corticosteroid Induced Osteoporosis in Japanese Patients with Connective Tissue Disease

T2 - 3 Year Followup

AU - Sato, Shinji

AU - Ohosone, Yasuo

AU - Suwa, Akira

AU - Yasuoka, Hidekata

AU - Nojima, Takaki

AU - Fujii, Takao

AU - Kuwana, Masataka

AU - Nakamura, Kunio

AU - Mimori, Tsuneyo

AU - Hirakata, Michito

PY - 2003/12

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N2 - Objective. A 3 year prospective randomized study was conducted to clarify the efficacy of intermittent cyclical etidronate therapy on corticosteroid induced osteoporosis. Methods. A group of 102 Japanese patients were enrolled, each taking > 7.5 mg of prednisolone daily for at least 90 days. Patients were randomly divided into 2 treatment groups: Group E (etidronate) took 200 mg etidronate disodium per day for 2 weeks with 3.0 g calcium lactate and 0.75 μg alphacalcidol daily; Group C (control) took 3.0 g calcium lactate and 0. 75 μg alphacalcidol daily. Outcome measurements included changes from baseline in bone mineral density (BMD) of the lumbar spine and the rate of new vertebral fractures at 48 and 144 weeks. Results. The mean (± SD) lumbar spine BMD increased 3.7 ± 5.6% (p < 0.01) and 1.5 ± 4.1% (NS) from baseline at 48 weeks and 4.8 ± 6.9% (p < 0.005) and 0.4 ± 5.0% (NS) from baseline at 144 weeks in Group E and Group C, respectively. The improvement of BMD in Group E was significantly greater than in Group C at 144 weeks (p < 0.01). In 3 subgroups, men and premenopausal and postmenopausal women, the postmenopausal women showed the greatest improvement. Mean percentage change in this subgroup was 10.1 ± 8.0% and 1.35 ± 6. 4% in Group E and Group C, respectively. We noted that 2 patients in Group C had new vertebral fractures, whereas no fractures were observed in Group E. Conclusion. These results indicate that intermittent cyclical etidronate therapy is effective for the prevention and treatment of corticosteroid induced osteoporosis in patients with connective tissue diseases.

AB - Objective. A 3 year prospective randomized study was conducted to clarify the efficacy of intermittent cyclical etidronate therapy on corticosteroid induced osteoporosis. Methods. A group of 102 Japanese patients were enrolled, each taking > 7.5 mg of prednisolone daily for at least 90 days. Patients were randomly divided into 2 treatment groups: Group E (etidronate) took 200 mg etidronate disodium per day for 2 weeks with 3.0 g calcium lactate and 0.75 μg alphacalcidol daily; Group C (control) took 3.0 g calcium lactate and 0. 75 μg alphacalcidol daily. Outcome measurements included changes from baseline in bone mineral density (BMD) of the lumbar spine and the rate of new vertebral fractures at 48 and 144 weeks. Results. The mean (± SD) lumbar spine BMD increased 3.7 ± 5.6% (p < 0.01) and 1.5 ± 4.1% (NS) from baseline at 48 weeks and 4.8 ± 6.9% (p < 0.005) and 0.4 ± 5.0% (NS) from baseline at 144 weeks in Group E and Group C, respectively. The improvement of BMD in Group E was significantly greater than in Group C at 144 weeks (p < 0.01). In 3 subgroups, men and premenopausal and postmenopausal women, the postmenopausal women showed the greatest improvement. Mean percentage change in this subgroup was 10.1 ± 8.0% and 1.35 ± 6. 4% in Group E and Group C, respectively. We noted that 2 patients in Group C had new vertebral fractures, whereas no fractures were observed in Group E. Conclusion. These results indicate that intermittent cyclical etidronate therapy is effective for the prevention and treatment of corticosteroid induced osteoporosis in patients with connective tissue diseases.

KW - Bisphosphonate

KW - Bone mineral density

KW - Connective tissue diseases

KW - Corticosteroid induced osteoporosis

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