Effect of methamphetamine on cortisone concentration, NK cell activity and mitogen response of T-lymphocytes in female cynomolgus monkeys

Masayoshi Saito, Takao Yamaguchi, Tetsuya Kawata, Hisao Ito, Takao Kanai, Masaru Terada, Makoto Yokosuka, Toru R. Saito

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

As a model for studying methamphetamine (MAP) abuse, which has become a social problem in Japan, we investigated the changes in serum cortisone, NK cell activity and mitogenic response of T-lymphocytes after a single injection of MAP (3.0 mg/kg) in female cynomolgus monkeys. Serum cortisol concentration was significantly elevated to 2.66 times pre-injection levels at 6 h post-injection, and the effect was still observed 24 h later. NK cell activity was significantly elevated at 6 h after MAP injection, but at 24 h after injection had dropped markedly to 49.5% of baseline. Mitogen (PHA) response of lymphocytes was elevated when MAP was injected, and this increased level continued up to 24 h. We speculate that the transient increase in NK cell activity followed by a distinct drop, as well as the changes in T-lymphocytes, may be strongly related to the cortisone concentration.

Original languageEnglish
Pages (from-to)477-481
Number of pages5
JournalExperimental Animals
Volume55
Issue number5
DOIs
Publication statusPublished - 2006 Nov 8

Keywords

  • Cynomolgus monkey
  • Immunosuppresion
  • Methamphetamine

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Biochemistry, Genetics and Molecular Biology(all)
  • veterinary(all)

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