Effect of metoclopramide onthe secretion of aldosterone and other adrenocortical steroids

S. Nagahama, M. Fujimaki, H. Kawabe

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The aim of this study was to determine the effect of metoclopramide, a dopamine antagonist, on the secretion of aldosterone and other adrenocortical steroids in normal subjects. An i.v. bolus injection of 10 mg of metoclopramide significantly increased the plasma PRL, plasma aldosterone and 18-hydroxycorticosterone, but the plasma renin activity, plasma deoxycorticosterone, corticosterone and cortisol remained unchanged. The changes in plasma aldosterone induced by metoclopramide were significantly correlated with the basal levels of plasma aldosterone and renin activity. These results suggest that the response of plasma aldosterone to metoclopramide in normal subjects is influenced by the basal activity of renin-angiotensin-aldosterone system and the late step of aldosterone synthesis is stimulated by metoclopramide.

Original languageEnglish
Pages (from-to)287-293
Number of pages7
JournalClinical Endocrinology
Volume18
Issue number3
Publication statusPublished - 1983

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Metoclopramide
Aldosterone
Steroids
Renin
18-Hydroxycorticosterone
Desoxycorticosterone
Dopamine Antagonists
Renin-Angiotensin System
Corticosterone
Hydrocortisone
Injections

ASJC Scopus subject areas

  • Endocrinology

Cite this

Effect of metoclopramide onthe secretion of aldosterone and other adrenocortical steroids. / Nagahama, S.; Fujimaki, M.; Kawabe, H.

In: Clinical Endocrinology, Vol. 18, No. 3, 1983, p. 287-293.

Research output: Contribution to journalArticle

Nagahama, S, Fujimaki, M & Kawabe, H 1983, 'Effect of metoclopramide onthe secretion of aldosterone and other adrenocortical steroids', Clinical Endocrinology, vol. 18, no. 3, pp. 287-293.
Nagahama, S. ; Fujimaki, M. ; Kawabe, H. / Effect of metoclopramide onthe secretion of aldosterone and other adrenocortical steroids. In: Clinical Endocrinology. 1983 ; Vol. 18, No. 3. pp. 287-293.
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