Effect of nimodipine, a calcium antagonist, on cerebral vasospasm after subarachnoid hemorrhage in cats

K. Tanaka, F. Gotoh, F. Muramatsu, Y. Fukuuchi, H. Okayasu, N. Suzuki, M. Kobari

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Effect of a calcium antagonist, isopropyl-(2-methoxyethyl)-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5- pyridinedicarboxylate (nimodipine) on the cerebral vasospasm after experimental subarachnoid hemorrhage (SAH) was studied in 10 adult cats. The vasospasm was induced by injection of 0.2-0.3 ml fresh autologous whole blood into the cisterna magna. Diameter of pial vessels was continuously measured by means of the vidicon camera system developed in our laboratory. Intravenous administration of nimodipine (0.1 mg/kg) 20-30 min after SAH resulted in a complete disappearance of the spasm with the reduction of blood pressure. The dilatatory response was more marked in the smaller arteries (< 100 μm) than in the larger ones (≥ 100 μm). Administration of a smaller dose of nimodipine (0.01 mg/kg) also produced dilation of the pial vessels, although the effect was less remarkable in the smaller arteries. These data suggest that nimodipine might be useful in the treatment of the cerebral vasospasm after SAH. The mechanism underlying the action of nimodipine was discussed.

Original languageEnglish
Pages (from-to)1529-1534
Number of pages6
JournalArzneimittel-Forschung/Drug Research
Volume32
Issue number12
Publication statusPublished - 1982
Externally publishedYes

Fingerprint

Intracranial Vasospasm
Nimodipine
Subarachnoid Hemorrhage
Cats
Calcium
Arteries
Cisterna Magna
Blood pressure
Spasm
Intravenous Administration
Dilatation
Blood
Cameras
Blood Pressure
Injections

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Chemistry(all)
  • Pharmacology

Cite this

Tanaka, K., Gotoh, F., Muramatsu, F., Fukuuchi, Y., Okayasu, H., Suzuki, N., & Kobari, M. (1982). Effect of nimodipine, a calcium antagonist, on cerebral vasospasm after subarachnoid hemorrhage in cats. Arzneimittel-Forschung/Drug Research, 32(12), 1529-1534.

Effect of nimodipine, a calcium antagonist, on cerebral vasospasm after subarachnoid hemorrhage in cats. / Tanaka, K.; Gotoh, F.; Muramatsu, F.; Fukuuchi, Y.; Okayasu, H.; Suzuki, N.; Kobari, M.

In: Arzneimittel-Forschung/Drug Research, Vol. 32, No. 12, 1982, p. 1529-1534.

Research output: Contribution to journalArticle

Tanaka, K, Gotoh, F, Muramatsu, F, Fukuuchi, Y, Okayasu, H, Suzuki, N & Kobari, M 1982, 'Effect of nimodipine, a calcium antagonist, on cerebral vasospasm after subarachnoid hemorrhage in cats', Arzneimittel-Forschung/Drug Research, vol. 32, no. 12, pp. 1529-1534.
Tanaka K, Gotoh F, Muramatsu F, Fukuuchi Y, Okayasu H, Suzuki N et al. Effect of nimodipine, a calcium antagonist, on cerebral vasospasm after subarachnoid hemorrhage in cats. Arzneimittel-Forschung/Drug Research. 1982;32(12):1529-1534.
Tanaka, K. ; Gotoh, F. ; Muramatsu, F. ; Fukuuchi, Y. ; Okayasu, H. ; Suzuki, N. ; Kobari, M. / Effect of nimodipine, a calcium antagonist, on cerebral vasospasm after subarachnoid hemorrhage in cats. In: Arzneimittel-Forschung/Drug Research. 1982 ; Vol. 32, No. 12. pp. 1529-1534.
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