Effect of Oral Pilocarpine in Treating Severe Dry Eye in Patients With Sjögren Syndrome

Tetsuya Kawakita, Shigeto Shimmura, Kazuo Tsubota

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Abstract

PURPOSE: The aim of this study is to evaluate the efficacy and safety of oral pilocarpine in treating severe dry eye unresponsive to conventional conservative treatment in patients with Sjögren syndrome.

DESIGN: A prospective study.

METHODS: Oral doses of pilocarpine were administered for at least 3 months to patients with Sjögren syndrome complicated by established dry eye of great severity unresponsive to conventional conservative treatment.

RESULTS: Subjective eye symptoms (dry eye sensation and eye pain), fluorescein staining scores, rose Bengal staining scores, and tear film breakup time measurements improved significantly after 1 month and 3 months of oral treatment with pilocarpine, whereas no significant improvement was noted in Schirmer I testing.

CONCLUSIONS: Oral administration of pilocarpine was useful in treating severe dry eye unresponsive to conventional conservative treatment in patients with Sjögren syndrome from the standpoint of efficacy and safety. Thus, we conclude that oral pilocarpine is effective as a new option in treating severe dry eye.

Original languageEnglish
Pages (from-to)101-105
Number of pages5
JournalAsia-Pacific Journal of Ophthalmology
Volume4
Issue number2
DOIs
Publication statusPublished - 2015 Mar 1

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ASJC Scopus subject areas

  • Medicine(all)

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