Effect of orally administered Hochu-ekki-to, a Japanese herbal medicine, on contact hypersensitivity caused by repeated application of antigen

Tsutomu Nakada, Kenji Watanabe, Tsukasa Matsumoto, Kazuki Santa, Kazuo Triizuka, Toshihiko Hanawa

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

The effects of oral administration of Hochu-ekki-to (HET; bu-zhong-yi-qi-tang in Chinese), a traditional Japanese and Chinese herbal medicine, on chronic contact hypersensitivity were investigated. HET suppressed ear swelling due to chronic contact hypersensitivity caused by repeated application of 2,4,6-trinitro-1-chlorobenzene (TNCB). HET significantly suppressed not only increases in hapten-specific immunoglobulin E (IgE) and IgG1 titer due to repeated application of TNCB, but also total IgE and IgG1 concentration in the serum. Interleukin 4 (IL-4) level in inflamed ear tissue was significantly increased by repeated application of TNCB, and this increase in IL-4 level in the ear was significantly suppressed by oral administration of HET. Interferon γ (IFN-γ), IL-2, IL-5, IL-10 and IL-12 levels are not changed as much as IL-4 by TNCB and HET did not alter these cytokines as much as IL-4. These results suggest that oral administration of HET suppresses chronic contact hypersensitivity, and it can be assumed that the suppression of serum Ig E and Ig G1 and IL-4 in inflamed ear.

Original languageEnglish
Pages (from-to)901-911
Number of pages11
JournalInternational Immunopharmacology
Volume2
Issue number7
DOIs
Publication statusPublished - 2002

Fingerprint

Herbal Medicine
Contact Dermatitis
Interleukin-4
Picryl Chloride
Ear
Antigens
Oral Administration
Immunoglobulin E
Interleukin-2
Immunoglobulin G
Haptens
Interleukin-5
Interleukin-12
Serum
Interleukin-10
Interferons
bu-zhong-yi-qi-tang
Cytokines

Keywords

  • Contact hypersensitivity
  • Hochu-ekkki-to
  • IgE
  • IL-4

ASJC Scopus subject areas

  • Immunology
  • Pharmacology

Cite this

Effect of orally administered Hochu-ekki-to, a Japanese herbal medicine, on contact hypersensitivity caused by repeated application of antigen. / Nakada, Tsutomu; Watanabe, Kenji; Matsumoto, Tsukasa; Santa, Kazuki; Triizuka, Kazuo; Hanawa, Toshihiko.

In: International Immunopharmacology, Vol. 2, No. 7, 2002, p. 901-911.

Research output: Contribution to journalArticle

Nakada, Tsutomu ; Watanabe, Kenji ; Matsumoto, Tsukasa ; Santa, Kazuki ; Triizuka, Kazuo ; Hanawa, Toshihiko. / Effect of orally administered Hochu-ekki-to, a Japanese herbal medicine, on contact hypersensitivity caused by repeated application of antigen. In: International Immunopharmacology. 2002 ; Vol. 2, No. 7. pp. 901-911.
@article{59e43bbcfe06492593ed3430c9e1ddd5,
title = "Effect of orally administered Hochu-ekki-to, a Japanese herbal medicine, on contact hypersensitivity caused by repeated application of antigen",
abstract = "The effects of oral administration of Hochu-ekki-to (HET; bu-zhong-yi-qi-tang in Chinese), a traditional Japanese and Chinese herbal medicine, on chronic contact hypersensitivity were investigated. HET suppressed ear swelling due to chronic contact hypersensitivity caused by repeated application of 2,4,6-trinitro-1-chlorobenzene (TNCB). HET significantly suppressed not only increases in hapten-specific immunoglobulin E (IgE) and IgG1 titer due to repeated application of TNCB, but also total IgE and IgG1 concentration in the serum. Interleukin 4 (IL-4) level in inflamed ear tissue was significantly increased by repeated application of TNCB, and this increase in IL-4 level in the ear was significantly suppressed by oral administration of HET. Interferon γ (IFN-γ), IL-2, IL-5, IL-10 and IL-12 levels are not changed as much as IL-4 by TNCB and HET did not alter these cytokines as much as IL-4. These results suggest that oral administration of HET suppresses chronic contact hypersensitivity, and it can be assumed that the suppression of serum Ig E and Ig G1 and IL-4 in inflamed ear.",
keywords = "Contact hypersensitivity, Hochu-ekkki-to, IgE, IL-4",
author = "Tsutomu Nakada and Kenji Watanabe and Tsukasa Matsumoto and Kazuki Santa and Kazuo Triizuka and Toshihiko Hanawa",
year = "2002",
doi = "10.1016/S1567-5769(02)00027-9",
language = "English",
volume = "2",
pages = "901--911",
journal = "International Immunopharmacology",
issn = "1567-5769",
publisher = "Elsevier",
number = "7",

}

TY - JOUR

T1 - Effect of orally administered Hochu-ekki-to, a Japanese herbal medicine, on contact hypersensitivity caused by repeated application of antigen

AU - Nakada, Tsutomu

AU - Watanabe, Kenji

AU - Matsumoto, Tsukasa

AU - Santa, Kazuki

AU - Triizuka, Kazuo

AU - Hanawa, Toshihiko

PY - 2002

Y1 - 2002

N2 - The effects of oral administration of Hochu-ekki-to (HET; bu-zhong-yi-qi-tang in Chinese), a traditional Japanese and Chinese herbal medicine, on chronic contact hypersensitivity were investigated. HET suppressed ear swelling due to chronic contact hypersensitivity caused by repeated application of 2,4,6-trinitro-1-chlorobenzene (TNCB). HET significantly suppressed not only increases in hapten-specific immunoglobulin E (IgE) and IgG1 titer due to repeated application of TNCB, but also total IgE and IgG1 concentration in the serum. Interleukin 4 (IL-4) level in inflamed ear tissue was significantly increased by repeated application of TNCB, and this increase in IL-4 level in the ear was significantly suppressed by oral administration of HET. Interferon γ (IFN-γ), IL-2, IL-5, IL-10 and IL-12 levels are not changed as much as IL-4 by TNCB and HET did not alter these cytokines as much as IL-4. These results suggest that oral administration of HET suppresses chronic contact hypersensitivity, and it can be assumed that the suppression of serum Ig E and Ig G1 and IL-4 in inflamed ear.

AB - The effects of oral administration of Hochu-ekki-to (HET; bu-zhong-yi-qi-tang in Chinese), a traditional Japanese and Chinese herbal medicine, on chronic contact hypersensitivity were investigated. HET suppressed ear swelling due to chronic contact hypersensitivity caused by repeated application of 2,4,6-trinitro-1-chlorobenzene (TNCB). HET significantly suppressed not only increases in hapten-specific immunoglobulin E (IgE) and IgG1 titer due to repeated application of TNCB, but also total IgE and IgG1 concentration in the serum. Interleukin 4 (IL-4) level in inflamed ear tissue was significantly increased by repeated application of TNCB, and this increase in IL-4 level in the ear was significantly suppressed by oral administration of HET. Interferon γ (IFN-γ), IL-2, IL-5, IL-10 and IL-12 levels are not changed as much as IL-4 by TNCB and HET did not alter these cytokines as much as IL-4. These results suggest that oral administration of HET suppresses chronic contact hypersensitivity, and it can be assumed that the suppression of serum Ig E and Ig G1 and IL-4 in inflamed ear.

KW - Contact hypersensitivity

KW - Hochu-ekkki-to

KW - IgE

KW - IL-4

UR - http://www.scopus.com/inward/record.url?scp=0036310023&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036310023&partnerID=8YFLogxK

U2 - 10.1016/S1567-5769(02)00027-9

DO - 10.1016/S1567-5769(02)00027-9

M3 - Article

C2 - 12188032

AN - SCOPUS:0036310023

VL - 2

SP - 901

EP - 911

JO - International Immunopharmacology

JF - International Immunopharmacology

SN - 1567-5769

IS - 7

ER -