Effect of peripheral blood mononuclear cells from aplastic anemia patients on the granulocyte-macrophage and erythroid colony formation in samples from normal human bone marrow in vitro - A cooperative work

F. Takaku; T. Suda; H. Mizoguchi; Y. Miura; H. Uchino; K. Nagai; S. Kariyone; A. Shibata; T. Akabane; T. Nomura; T. Maekawa

doi:10.1182/blood.v55.6.937.937

Effect of peripheral blood mononuclear cells from aplastic anemia patients on the granulocyte-macrophage and erythroid colony formation in samples from normal human bone marrow in vitro - A cooperative work

F. Takaku, T. Suda, H. Mizoguchi, Y. Miura, H. Uchino, K. Nagai, S. Kariyone, A. Shibata, T. Akabane, T. Nomura, T. Maekawa

The Sakaguchi Laboratory of Developmental Biology Department of Cell Differentiation

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22 Citations (Scopus)

Abstract

Thirty-six patients with aplastic anemia and three with aplastic anemia-PNH syndrome in eight institutes were studied for the presence of peripheral blood mononuclear cells having a suppressive effect on granulocyte-macrophage (G-M) and erythroid colony formation using a uniform protocol. In 11 cases of 29 (38%) and 9 cases of 29 (31%), the presence of mononuclear cells with a suppressive effect on G-M and erythroid colony formation, respectively, was demonstrated. However, the presence of mononuclear cells suppressive both to G-M and erythroid colony formation was demonstrated only in 3 of 19 cases (16%).

Original language	English
Pages (from-to)	937-943
Number of pages	7
Journal	Blood
Volume	55
Issue number	6
DOIs	https://doi.org/10.1182/blood.v55.6.937.937
Publication status	Published - 1980

ASJC Scopus subject areas

Biochemistry
Immunology
Hematology
Cell Biology

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Takaku, F., Suda, T., Mizoguchi, H., Miura, Y., Uchino, H., Nagai, K., Kariyone, S., Shibata, A., Akabane, T., Nomura, T., & Maekawa, T. (1980). Effect of peripheral blood mononuclear cells from aplastic anemia patients on the granulocyte-macrophage and erythroid colony formation in samples from normal human bone marrow in vitro - A cooperative work. Blood, 55(6), 937-943. https://doi.org/10.1182/blood.v55.6.937.937

Effect of peripheral blood mononuclear cells from aplastic anemia patients on the granulocyte-macrophage and erythroid colony formation in samples from normal human bone marrow in vitro - A cooperative work. / Takaku, F.; Suda, T.; Mizoguchi, H.; Miura, Y.; Uchino, H.; Nagai, K.; Kariyone, S.; Shibata, A.; Akabane, T.; Nomura, T.; Maekawa, T.

In: Blood, Vol. 55, No. 6, 1980, p. 937-943.

Research output: Contribution to journal › Article › peer-review

Takaku, F, Suda, T, Mizoguchi, H, Miura, Y, Uchino, H, Nagai, K, Kariyone, S, Shibata, A, Akabane, T, Nomura, T & Maekawa, T 1980, 'Effect of peripheral blood mononuclear cells from aplastic anemia patients on the granulocyte-macrophage and erythroid colony formation in samples from normal human bone marrow in vitro - A cooperative work', Blood, vol. 55, no. 6, pp. 937-943. https://doi.org/10.1182/blood.v55.6.937.937

Takaku, F. ; Suda, T. ; Mizoguchi, H. ; Miura, Y. ; Uchino, H. ; Nagai, K. ; Kariyone, S. ; Shibata, A. ; Akabane, T. ; Nomura, T. ; Maekawa, T. / Effect of peripheral blood mononuclear cells from aplastic anemia patients on the granulocyte-macrophage and erythroid colony formation in samples from normal human bone marrow in vitro - A cooperative work. In: Blood. 1980 ; Vol. 55, No. 6. pp. 937-943.

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abstract = "Thirty-six patients with aplastic anemia and three with aplastic anemia-PNH syndrome in eight institutes were studied for the presence of peripheral blood mononuclear cells having a suppressive effect on granulocyte-macrophage (G-M) and erythroid colony formation using a uniform protocol. In 11 cases of 29 (38%) and 9 cases of 29 (31%), the presence of mononuclear cells with a suppressive effect on G-M and erythroid colony formation, respectively, was demonstrated. However, the presence of mononuclear cells suppressive both to G-M and erythroid colony formation was demonstrated only in 3 of 19 cases (16%).",

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Effect of peripheral blood mononuclear cells from aplastic anemia patients on the granulocyte-macrophage and erythroid colony formation in samples from normal human bone marrow in vitro - A cooperative work

Abstract

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