Effect of peripheral blood mononuclear cells from aplastic anemia patients on the granulocyte-macrophage and erythroid colony formation in samples from normal human bone marrow in vitro - A cooperative work

F. Takaku, T. Suda, H. Mizoguchi, Y. Miura, H. Uchino, K. Nagai, S. Kariyone, A. Shibata, T. Akabane, T. Nomura, T. Maekawa

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Abstract

Thirty-six patients with aplastic anemia and three with aplastic anemia-PNH syndrome in eight institutes were studied for the presence of peripheral blood mononuclear cells having a suppressive effect on granulocyte-macrophage (G-M) and erythroid colony formation using a uniform protocol. In 11 cases of 29 (38%) and 9 cases of 29 (31%), the presence of mononuclear cells with a suppressive effect on G-M and erythroid colony formation, respectively, was demonstrated. However, the presence of mononuclear cells suppressive both to G-M and erythroid colony formation was demonstrated only in 3 of 19 cases (16%).

Original languageEnglish
Pages (from-to)937-943
Number of pages7
JournalBlood
Volume55
Issue number6
Publication statusPublished - 1980

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Aplastic Anemia
Macrophages
Granulocytes
Blood Cells
Bone
Blood
Bone Marrow
In Vitro Techniques

ASJC Scopus subject areas

  • Hematology

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Effect of peripheral blood mononuclear cells from aplastic anemia patients on the granulocyte-macrophage and erythroid colony formation in samples from normal human bone marrow in vitro - A cooperative work. / Takaku, F.; Suda, T.; Mizoguchi, H.; Miura, Y.; Uchino, H.; Nagai, K.; Kariyone, S.; Shibata, A.; Akabane, T.; Nomura, T.; Maekawa, T.

In: Blood, Vol. 55, No. 6, 1980, p. 937-943.

Research output: Contribution to journalArticle

Takaku, F, Suda, T, Mizoguchi, H, Miura, Y, Uchino, H, Nagai, K, Kariyone, S, Shibata, A, Akabane, T, Nomura, T & Maekawa, T 1980, 'Effect of peripheral blood mononuclear cells from aplastic anemia patients on the granulocyte-macrophage and erythroid colony formation in samples from normal human bone marrow in vitro - A cooperative work', Blood, vol. 55, no. 6, pp. 937-943.
Takaku, F. ; Suda, T. ; Mizoguchi, H. ; Miura, Y. ; Uchino, H. ; Nagai, K. ; Kariyone, S. ; Shibata, A. ; Akabane, T. ; Nomura, T. ; Maekawa, T. / Effect of peripheral blood mononuclear cells from aplastic anemia patients on the granulocyte-macrophage and erythroid colony formation in samples from normal human bone marrow in vitro - A cooperative work. In: Blood. 1980 ; Vol. 55, No. 6. pp. 937-943.
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AU - Mizoguchi, H.

AU - Miura, Y.

AU - Uchino, H.

AU - Nagai, K.

AU - Kariyone, S.

AU - Shibata, A.

AU - Akabane, T.

AU - Nomura, T.

AU - Maekawa, T.

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