Effect of peripheral blood mononuclear cells from aplastic anemia patients on the granulocyte-macrophage and erythroid colony formation in samples from normal human bone marrow in vitro - A cooperative work

F. Takaku, T. Suda, H. Mizoguchi, Y. Miura, H. Uchino, K. Nagai, S. Kariyone, A. Shibata, T. Akabane, T. Nomura, T. Maekawa

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22 Citations (Scopus)

Abstract

Thirty-six patients with aplastic anemia and three with aplastic anemia-PNH syndrome in eight institutes were studied for the presence of peripheral blood mononuclear cells having a suppressive effect on granulocyte-macrophage (G-M) and erythroid colony formation using a uniform protocol. In 11 cases of 29 (38%) and 9 cases of 29 (31%), the presence of mononuclear cells with a suppressive effect on G-M and erythroid colony formation, respectively, was demonstrated. However, the presence of mononuclear cells suppressive both to G-M and erythroid colony formation was demonstrated only in 3 of 19 cases (16%).

Original languageEnglish
Pages (from-to)937-943
Number of pages7
JournalBlood
Volume55
Issue number6
Publication statusPublished - 1980 Aug 18

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

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    Takaku, F., Suda, T., Mizoguchi, H., Miura, Y., Uchino, H., Nagai, K., Kariyone, S., Shibata, A., Akabane, T., Nomura, T., & Maekawa, T. (1980). Effect of peripheral blood mononuclear cells from aplastic anemia patients on the granulocyte-macrophage and erythroid colony formation in samples from normal human bone marrow in vitro - A cooperative work. Blood, 55(6), 937-943.