Effect of proton pump inhibitors (PPIs) on wound healing of gastric mucosal cell injury

Tatsuhiro Masaoka, Hidekazu Suzuki, Hiromasa Ishii

Research output: Contribution to journalArticle


The pH-independent effect of PPI such as lansoprazole(LPZ) on cell restitution was shown in vitro. After wounding, addition of LPZ significantly promoted the cell restitution rate. While the addition of MEK inhibitor significantly attenuated the cell restitution rate in the LPZ groups, suggesting that mechanism of cell proliferation and migration promoted by LPZ might involve the activation of p44/p42 MAPK.

Original languageEnglish
Pages (from-to)556-560
Number of pages5
JournalNippon rinsho. Japanese journal of clinical medicine
Issue number3
Publication statusPublished - 2004


Cite this