Effect of rebamipide on H. pylori-associated gastric mucosal injury in Mongolian gerbils

Hidekazu Suzuki, M. Mori, A. Kai, M. Suzuki, M. Suematsu, S. Miura, H. Ishii

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Helicobacter pylori colonized to gastric mucosa plays an important pathogenic role in gastric mucosal lesions. We previously reported that ethanol pretreatment promotes the extension of H. pylori-associated lesions. The present study was designed to examine the effect of rebamipide, a mucosal protective agent, on H. pylori-associated injury. Male Mongolian gerbils were orally inoculated with H. pylori; 30 min prior to inoculation, 40% ethanol was administered orally to these gerbils (Hp group). Controls were given 40% ethanol with culture medium (control group). Some gerbils in the Hp find control groups were fed rebamipide-containing diets, and the remaining gerbils received laboratory chow diets. H. pylori infection was evaluated by quantitative bacterial culture and histological examination. Although H. pylori was persistently detected and a remarkable mucosal leukocyte infiltration was observed in the Hp groups, the bacteria had disappeared naturally in 67% of the gerbils and mucosal damage was mitigated in the Hp + rebamipide group at four weeks after the inoculation. Collectively, rebamipide might play a role in inhibiting the level of H. pylori colonization and gastric lesion formation in Mongolian gerbils.

Original languageEnglish
JournalDigestive Diseases and Sciences
Volume43
Issue number9 SUPPL.
Publication statusPublished - 1998

Fingerprint

Gerbillinae
Pylorus
Helicobacter pylori
Stomach
Wounds and Injuries
Ethanol
Diet
Protective Agents
Control Groups
Helicobacter Infections
Gastric Mucosa
rebamipide
Culture Media
Leukocytes
Bacteria

Keywords

  • Colonization density
  • Helicobacter pylori
  • Leukocyte
  • Sydney system

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Suzuki, H., Mori, M., Kai, A., Suzuki, M., Suematsu, M., Miura, S., & Ishii, H. (1998). Effect of rebamipide on H. pylori-associated gastric mucosal injury in Mongolian gerbils. Digestive Diseases and Sciences, 43(9 SUPPL.).

Effect of rebamipide on H. pylori-associated gastric mucosal injury in Mongolian gerbils. / Suzuki, Hidekazu; Mori, M.; Kai, A.; Suzuki, M.; Suematsu, M.; Miura, S.; Ishii, H.

In: Digestive Diseases and Sciences, Vol. 43, No. 9 SUPPL., 1998.

Research output: Contribution to journalArticle

Suzuki, H, Mori, M, Kai, A, Suzuki, M, Suematsu, M, Miura, S & Ishii, H 1998, 'Effect of rebamipide on H. pylori-associated gastric mucosal injury in Mongolian gerbils', Digestive Diseases and Sciences, vol. 43, no. 9 SUPPL..
Suzuki H, Mori M, Kai A, Suzuki M, Suematsu M, Miura S et al. Effect of rebamipide on H. pylori-associated gastric mucosal injury in Mongolian gerbils. Digestive Diseases and Sciences. 1998;43(9 SUPPL.).
Suzuki, Hidekazu ; Mori, M. ; Kai, A. ; Suzuki, M. ; Suematsu, M. ; Miura, S. ; Ishii, H. / Effect of rebamipide on H. pylori-associated gastric mucosal injury in Mongolian gerbils. In: Digestive Diseases and Sciences. 1998 ; Vol. 43, No. 9 SUPPL.
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