Effect of rebamipide on H. pylori-associated gastric mucosal injury in Mongolian gerbils

H. Suzuki, M. Mori, A. Kai, M. Suzuki, M. Suematsu, S. Miura, H. Ishii

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Abstract

Helicobacter pylori colonized to gastric mucosa plays an important pathogenic role in gastric mucosal lesions. We previously reported that ethanol pretreatment promotes the extension of H. pylori-associated lesions. The present study was designed to examine the effect of rebamipide, a mucosal protective agent, on H. pylori-associated injury. Male Mongolian gerbils were orally inoculated with H. pylori; 30 min prior to inoculation, 40% ethanol was administered orally to these gerbils (Hp group). Controls were given 40% ethanol with culture medium (control group). Some gerbils in the Hp find control groups were fed rebamipide-containing diets, and the remaining gerbils received laboratory chow diets. H. pylori infection was evaluated by quantitative bacterial culture and histological examination. Although H. pylori was persistently detected and a remarkable mucosal leukocyte infiltration was observed in the Hp groups, the bacteria had disappeared naturally in 67% of the gerbils and mucosal damage was mitigated in the Hp + rebamipide group at four weeks after the inoculation. Collectively, rebamipide might play a role in inhibiting the level of H. pylori colonization and gastric lesion formation in Mongolian gerbils.

Original languageEnglish
Pages (from-to)181S-187S
JournalDigestive Diseases and Sciences
Volume43
Issue number9 SUPPL.
Publication statusPublished - 1998 Oct 3

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Keywords

  • Colonization density
  • Helicobacter pylori
  • Leukocyte
  • Sydney system

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology

Cite this

Suzuki, H., Mori, M., Kai, A., Suzuki, M., Suematsu, M., Miura, S., & Ishii, H. (1998). Effect of rebamipide on H. pylori-associated gastric mucosal injury in Mongolian gerbils. Digestive Diseases and Sciences, 43(9 SUPPL.), 181S-187S.