Effect of risedronate on speed of sound in postmenopausal women with osteoporosis

Jun Iwamoto, Tetsuya Takada, Yoshihiro Sato, Hideo Matsumoto

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Aim: To examine the effects of treatment with risedronate for 1 year on speed of sound (SOS) of the calcaneus and bone turnover markers in postmenopausal women with osteoporosis. Methods: Thirty-eight postmenopausal women with osteoporosis who had been treated with risedronate for > 1 year were enrolled in the study. The SOS and bone turnover markers were monitored during treatment with risedronate for 1 year. Results: The urinary levels of cross-linked N-terminal telopeptides of type I collagen and serum levels of alkaline phosphatase were significantly decreased at 3 mo (-34.7%) and 12 mo (-21.2%), respectively, compared with the baseline values. The SOS increased modestly, but significantly by 0.65% at 12 mo compared with the baseline value. Treatment with risedronate elicited an increase in the SOS of the calcaneus exceeding the coefficient of variation in vivo (0.27%). Conclusion: The present study confirmed that risedronate suppressed bone turnover and elicited a clinically significant increase in the SOS of the calcaneus in postmenopausal women with osteoporosis.

Original languageEnglish
Pages (from-to)316-322
Number of pages7
JournalWorld Journal of Orthopaedics
Volume4
Issue number4
DOIs
Publication statusPublished - 2013 Oct 18

Keywords

  • Bone turnover
  • Postmenopausal women
  • Quantitative ultrasound
  • Risedronate
  • Speed of sound

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine

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