Effect of Scattering on spectral Imaging of Exposed Cortical Tissue for Brain Function Measurement

Motoshi Watanabe, Kentaro Yokoyama, Kazushi Honjo, Eiji Okada

Research output: Contribution to journalArticle

Abstract

Optical imaging of an exposed cortex for brain function measurement is an attractive method for both clinical and physiological investigations. Spectral imaging of the exposed cortical tissue enables measurement of the activity-dependent changes in oxy- and deoxy-haemoglobin independently. Since the diffusely reflected light from the exposed cortex is highly scattered in the cortical tissue, the wavelength dependence of the optical properties of the tissue is likely to affect the images of oxy- and deoxy-haemoglobin changes obtained from the spectral images. In this study, the spectral images of the model of exposed cortical tissue are calculated by Monte Carlo simulation to investigate the influence of blurring by tissue scattering on the brain function measurement by the imaging. The images of the change in oxy- and deoxy-haemoglobin obtained from the spectral images at near infrared wavelengths are broadened and blurred due to the scattering in the cortical tissue. The influence of cross talk is more significant in the image calculated from the spectral images at the visible wavelengths. Inappropriate choice of the spectral range of images might increase cross talk and error in the images of oxy- and deoxy-haemoglobin changes.

Original languageEnglish
Pages (from-to)474-477
Number of pages4
JournalOptical Review
Volume10
Issue number5
Publication statusPublished - 2003 Sep

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brain
oxyhemoglobin
scattering
hemoglobin
cortexes
wavelengths
blurring
optical properties

Keywords

  • Biomedical optics
  • Cross talk
  • Monte Carlo simulation
  • Spectral imaging

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics

Cite this

Effect of Scattering on spectral Imaging of Exposed Cortical Tissue for Brain Function Measurement. / Watanabe, Motoshi; Yokoyama, Kentaro; Honjo, Kazushi; Okada, Eiji.

In: Optical Review, Vol. 10, No. 5, 09.2003, p. 474-477.

Research output: Contribution to journalArticle

Watanabe, Motoshi ; Yokoyama, Kentaro ; Honjo, Kazushi ; Okada, Eiji. / Effect of Scattering on spectral Imaging of Exposed Cortical Tissue for Brain Function Measurement. In: Optical Review. 2003 ; Vol. 10, No. 5. pp. 474-477.
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