Effect of silicate incorporation on in vivo responses of α-tricalcium phosphate ceramics

Masanobu Kamitakahara, Eri Tatsukawa, Yasuaki Shibata, Shota Umemoto, Taishi Yokoi, Koji Ioku, Tohru Ikeda

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

In addition to calcium phosphate-based ceramics, glass-based materials have been utilized as bone substitutes, and silicate in these materials has been suggested to contribute to their ability to stimulate bone repair. In this study, a silicate-containing α-tricalcium phosphate (α-TCP) ceramic was prepared using a wet chemical process. Porous granules composed of silicate-containing α-TCP, for which the starting composition had a molar ratio of 0.05 for Si/(P + Si), and silicate-free α-TCP were prepared and evaluated in vivo. When implanted into bone defects that were created in rat femurs, α-TCP ceramics either with or without silicate were biodegraded, generating a hybrid tissue composed of residual ceramic granules and newly formed bone, which had a tissue architecture similar to physiological trabecular structures, and aided regeneration of the bone defects. Supplementation with silicate significantly promoted osteogenesis and delayed biodegradation of α-TCP. These results suggest that silicate-containing α-TCP is advantageous for initial skeletal fixation and wound regeneration in bone repair.

Original languageEnglish
Article number97
JournalJournal of Materials Science: Materials in Medicine
Volume27
Issue number5
DOIs
Publication statusPublished - 2016 May 1

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Silicates
Phosphates
Bone
Bone Regeneration
Ceramics
Bone and Bones
Repair
Chemical Phenomena
Tissue
Bone Substitutes
Fracture Fixation
Defects
Calcium phosphate
Glass ceramics
Biodegradation
tricalcium phosphate
Polysilicon
Osteogenesis
Femur
Rats

ASJC Scopus subject areas

  • Biophysics
  • Biomaterials
  • Bioengineering
  • Biomedical Engineering

Cite this

Effect of silicate incorporation on in vivo responses of α-tricalcium phosphate ceramics. / Kamitakahara, Masanobu; Tatsukawa, Eri; Shibata, Yasuaki; Umemoto, Shota; Yokoi, Taishi; Ioku, Koji; Ikeda, Tohru.

In: Journal of Materials Science: Materials in Medicine, Vol. 27, No. 5, 97, 01.05.2016.

Research output: Contribution to journalArticle

Kamitakahara, Masanobu ; Tatsukawa, Eri ; Shibata, Yasuaki ; Umemoto, Shota ; Yokoi, Taishi ; Ioku, Koji ; Ikeda, Tohru. / Effect of silicate incorporation on in vivo responses of α-tricalcium phosphate ceramics. In: Journal of Materials Science: Materials in Medicine. 2016 ; Vol. 27, No. 5.
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