Effect of skin flap ischemia and surgical stress on plasma endothelin-1 levels

K. Matsuzaki, H. Inoue, M. Aihara, E. Isono, N. Tane, H. Ishida, H. Izawa

Research output: Contribution to journalArticle

Abstract

Vasospasms within the microvasculature of a flap can be a cause of ischemia and flap non-viability. Endothelin-1 (ET-1), a 21-amino acid polypeptide isolated from vascular endothelium culture media, is reported to be one of the most potent vasoconstrictors known, the authors have investigated whether skin flap ischemia and/or surgical stress had an influence on the plasma level of ET-1 in 5 cases of an intra-oral reconstruction using a radial forearm flap from October 1992 to March 1993. After the flap had been subjected to 2 hours of ischemia, blood was drawn from the venous effluent of each flap and the ET-1 content was evaluated. It was found that the plasma ET-1 levels of the flap had not significantly changed compared with the ET-1 level in the peripheral venous blood. Further, the plasma ET-1 levels after general anesthesia did not differ significantly from the pre-anesthetic levels, although the plasma ET-1 levels did significantly increase during the operation and were greater than the preoperative levels. Finally, the plasma ET-1 levels on postoperative day 1 tended to decrease compared with their levels during the operation. These results suggest that surgical stress influences the plasma ET-1 level. In the future, the measurement of ET-1 levels in flaps exposed to over 2 hours of ischemia should be investigated. Further, one thing that remains to be clarified is whether ET-1 is among the factors responsible for partial necrosis in skin flaps and the genesis of the no-reflow phenomenon.

Original languageEnglish
Pages (from-to)265-269
Number of pages5
JournalJapanese Journal of Plastic and Reconstructive Surgery
Volume37
Issue number3
Publication statusPublished - 1994
Externally publishedYes

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Surgical Flaps
Endothelin-1
Ischemia
Skin
No-Reflow Phenomenon
Vascular Endothelium
Vasoconstrictor Agents
Microvessels
Forearm
General Anesthesia
Culture Media
Anesthetics
Necrosis

ASJC Scopus subject areas

  • Surgery

Cite this

Matsuzaki, K., Inoue, H., Aihara, M., Isono, E., Tane, N., Ishida, H., & Izawa, H. (1994). Effect of skin flap ischemia and surgical stress on plasma endothelin-1 levels. Japanese Journal of Plastic and Reconstructive Surgery, 37(3), 265-269.

Effect of skin flap ischemia and surgical stress on plasma endothelin-1 levels. / Matsuzaki, K.; Inoue, H.; Aihara, M.; Isono, E.; Tane, N.; Ishida, H.; Izawa, H.

In: Japanese Journal of Plastic and Reconstructive Surgery, Vol. 37, No. 3, 1994, p. 265-269.

Research output: Contribution to journalArticle

Matsuzaki, K, Inoue, H, Aihara, M, Isono, E, Tane, N, Ishida, H & Izawa, H 1994, 'Effect of skin flap ischemia and surgical stress on plasma endothelin-1 levels', Japanese Journal of Plastic and Reconstructive Surgery, vol. 37, no. 3, pp. 265-269.
Matsuzaki K, Inoue H, Aihara M, Isono E, Tane N, Ishida H et al. Effect of skin flap ischemia and surgical stress on plasma endothelin-1 levels. Japanese Journal of Plastic and Reconstructive Surgery. 1994;37(3):265-269.
Matsuzaki, K. ; Inoue, H. ; Aihara, M. ; Isono, E. ; Tane, N. ; Ishida, H. ; Izawa, H. / Effect of skin flap ischemia and surgical stress on plasma endothelin-1 levels. In: Japanese Journal of Plastic and Reconstructive Surgery. 1994 ; Vol. 37, No. 3. pp. 265-269.
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