Effect of skin flap ischemia and surgical stress on plasma endothelin-1 levels

K. Matsuzaki, H. Inoue, M. Aihara, E. Isono, N. Tane, H. Ishida, H. Izawa

Research output: Contribution to journalArticle

Abstract

Vasospasms within the microvasculature of a flap can be a cause of ischemia and flap non-viability. Endothelin-1 (ET-1), a 21-amino acid polypeptide isolated from vascular endothelium culture media, is reported to be one of the most potent vasoconstrictors known, the authors have investigated whether skin flap ischemia and/or surgical stress had an influence on the plasma level of ET-1 in 5 cases of an intra-oral reconstruction using a radial forearm flap from October 1992 to March 1993. After the flap had been subjected to 2 hours of ischemia, blood was drawn from the venous effluent of each flap and the ET-1 content was evaluated. It was found that the plasma ET-1 levels of the flap had not significantly changed compared with the ET-1 level in the peripheral venous blood. Further, the plasma ET-1 levels after general anesthesia did not differ significantly from the pre-anesthetic levels, although the plasma ET-1 levels did significantly increase during the operation and were greater than the preoperative levels. Finally, the plasma ET-1 levels on postoperative day 1 tended to decrease compared with their levels during the operation. These results suggest that surgical stress influences the plasma ET-1 level. In the future, the measurement of ET-1 levels in flaps exposed to over 2 hours of ischemia should be investigated. Further, one thing that remains to be clarified is whether ET-1 is among the factors responsible for partial necrosis in skin flaps and the genesis of the no-reflow phenomenon.

Original languageEnglish
Pages (from-to)265-269
Number of pages5
JournalJapanese Journal of Plastic and Reconstructive Surgery
Volume37
Issue number3
Publication statusPublished - 1994
Externally publishedYes

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ASJC Scopus subject areas

  • Surgery

Cite this

Matsuzaki, K., Inoue, H., Aihara, M., Isono, E., Tane, N., Ishida, H., & Izawa, H. (1994). Effect of skin flap ischemia and surgical stress on plasma endothelin-1 levels. Japanese Journal of Plastic and Reconstructive Surgery, 37(3), 265-269.