Effect of synthesized constituents in the L-tryptophan product on the differentiation of eosinophils and the induction of IL-6: A possible cause of eosinophilia-myalgia syndrome

Yuji Yamaguchi, Jun ichi Tsunoda, Toshio Suda, Yasusada Miura, Kohei Shioiri-Nakano, Tadashi Kasahara

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

While the pathogenesis of eosinophilia-myalgia syndrome (EMS) remains obscure, the ingestion of L-trypophan (LT) and possibly certain constituents in the LT product might be associated. We investigated the effect of chemically synthesized substances, 1,1′-ethylidene bis[tryptophan] (EBT) and its decomposition product, 1-methyl-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid (MTCA) recently identified in the implicated LT, on the eosinophil differentiation and the induction of IL-1 and IL-6. EBT and MTCA alone did not support colony formation. However, EBT or MTCA in conjunction with IL-2 induced colony-forming activity containing a small number of eosinophils. In addition, these LT constitutents induced a significant level of IL-6 but not IL-1β in the mononuclear cells from normal volunteers and a patient with hypereosinophilic syndrome. These results suggest that certain constituents of LT product are associated with the pathogenesis of EMS through the induction of colony-stimulating factors and IL-6, hence giving rise to eosinophilia and inflammation.

Original languageEnglish
Pages (from-to)1008-1013
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume178
Issue number3
DOIs
Publication statusPublished - 1991 Aug 15

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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